PROTAMINE

ChemicalBook > CAS DataBase List > PROTAMINE

Product Name: PROTAMINE
CAS No.: 9012-00-4
Chemical Name: PROTAMINE
Synonyms: HSDB 3251;PROTAMINE;protamines;PROTAMINE USP/EP/BP;protamine from salmon;protamine free base grade iv;Protamine from salmon Grade IV, Histone, free(Millon test)
CBNumber: CB9468351
Formula Weight: 0
MOL File: Mol file

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PROTAMINE Property

storage temp.: -20°C
solubility: H₂O: clear

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Safety

WGK Germany: 3
RTECS: UK9440000
Hazardous Substances Data: 9012-00-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P4005
Product name: Protamine from salmon
Purity: Grade IV, Histone, free(Millon test)
Packaging: 1g
Price: $330
Updated: 2024/03/01

Sigma-Aldrich

Product number: P4005
Product name: Protamine from salmon
Purity: Grade IV, Histone, free(Millon test)
Packaging: 5g
Price: $1190
Updated: 2024/03/01

Sigma-Aldrich

Product number: P4005
Product name: Protamine from salmon
Purity: Grade IV, Histone, free(Millon test)
Packaging: 250mg
Price: $98.3
Updated: 2024/03/01

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PROTAMINE Chemical Properties,Usage,Production

Chemical Properties

Water soluble, producing basic solu- tions.

Uses

Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin. It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.

Definition

protamine: Any of a group of proteinsof relatively low molecularweight found in association with thechromosomal DNA of vertebratesperm cells. They contain a singlepolypeptide chain comprising about67% arginine. Protamines are thoughtto protect and support the chromosomes.

Definition

Simplest proteins, without sulfur, molecular weights about ～3000.

General Description

Protamines are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine. It is found to be localized to the sperm head.

Biochem/physiol Actions

Protamines are found to displace histones in DNA during spermatogenesis in animals and plants. Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.

Mechanism of action

Protamine sulfate has been approved in the United States as a specific antagonist to heparin since 1968. Protamines are an arginine-rich, highly basic group of simple proteins derived from salmon sperm. The highly acidic heparin polysaccharides exhibit their anticoagulant activity through binding to antithrombin III. Because of the basicity of protamine, heparin has an increased affinity for protamine relative to antithrombin III. In fact, its binding affinity for protamine is so much greater than that of antithrombin III that protamine actually will induce dissociation of the heparin/antithrombin III complex. If protamine is administered in the absence of heparin, it can have marked effects on coagulation. Protamine is not completely selective for heparin and, in vivo, also interacts with fibrinogen, platelets, and other plasma proteins causing anticoagulation. For this reason, use of the minimal amount of protamine necessary to antagonize heparin-associated bleeding should be employed (usually 1 mg of protamine intravenously for every 100 U of heparin remaining in the patient).

Side effects

Anaphylaxis also has been associated with the use of protamine. Although development of protamine anaphylaxis is not limited to diabetics, those patients with diabetes that have used protaminecontaining insulin (NPH or protamine zinc) do have a slightly increased risk of anaphylaxis. Some less common reactions to protamine include pulmonary vasoconstriction, hypotension, and thrombus formation.

PROTAMINE Preparation Products And Raw materials

Raw materials

Α-PROTEIN Ribonucleic acid

Preparation Products

Deoxynucleotide

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View Lastest Price from PROTAMINE manufacturers

Hebei Guanlang Biotechnology Co., Ltd.

Product: PROTAMINE 9012-00-4
Price: US $1.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-08-09

Hebei Mojin Biotechnology Co., Ltd

Product: PROTAMINE 9012-00-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-30

Jiangsu Boquan Biotechnology Co., Ltd.

Product: PROTAMINE 9012-00-4
Price: US $132.00-102.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2023-02-21

9012-00-4, PROTAMINERelated Search:

Fish peptone Fish, meal FishCollagen Fish Collagen (Hydrolyzed) USP/JP Fish steak powder Fish soluble functional peptide Benzyl isocyanide Ferric acetylacetonate PHENYLSELENOL SALCOMINE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TERT-BUTYL ISOCYANIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE Tosylmethyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) METHYL ISOCYANOACETATE Aluminum acetylacetonate N-BUTYLISOCYANIDE

protamines

PROTAMINE

protamine free base grade iv

protamine from salmon

HSDB 3251

PROTAMINE USP/EP/BP

Protamine from salmon Grade IV, Histone, free(Millon test)

9012-00-4

Biochemicals and Reagents

BioChemical

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