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PROTAMINE

Product Name
PROTAMINE
CAS No.
9012-00-4
Chemical Name
PROTAMINE
Synonyms
HSDB 3251;PROTAMINE;protamines;PROTAMINE USP/EP/BP;protamine from salmon;protamine free base grade iv;Protamine from salmon Grade IV, Histone, free(Millon test)
CBNumber
CB9468351
Formula Weight
0
MOL File
Mol file
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PROTAMINE Property

storage temp. 
-20°C
solubility 
H2O: clear
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Safety

WGK Germany 
3
RTECS 
UK9440000
Hazardous Substances Data
9012-00-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P4005
Product name
Protamine from salmon
Purity
Grade IV, Histone, free(Millon test)
Packaging
1g
Price
$330
Updated
2024/03/01
Sigma-Aldrich
Product number
P4005
Product name
Protamine from salmon
Purity
Grade IV, Histone, free(Millon test)
Packaging
5g
Price
$1190
Updated
2024/03/01
Sigma-Aldrich
Product number
P4005
Product name
Protamine from salmon
Purity
Grade IV, Histone, free(Millon test)
Packaging
250mg
Price
$98.3
Updated
2024/03/01
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PROTAMINE Chemical Properties,Usage,Production

Chemical Properties

Water soluble, producing basic solu- tions.

Uses

Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin. It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.

Definition

protamine: Any of a group of proteinsof relatively low molecularweight found in association with thechromosomal DNA of vertebratesperm cells. They contain a singlepolypeptide chain comprising about67% arginine. Protamines are thoughtto protect and support the chromosomes.

Definition

Simplest proteins, without sulfur, molecular weights about ~3000.

General Description

Protamines are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine. It is found to be localized to the sperm head.

Biochem/physiol Actions

Protamines are found to displace histones in DNA during spermatogenesis in animals and plants. Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.

Mechanism of action

Protamine sulfate has been approved in the United States as a specific antagonist to heparin since 1968. Protamines are an arginine-rich, highly basic group of simple proteins derived from salmon sperm. The highly acidic heparin polysaccharides exhibit their anticoagulant activity through binding to antithrombin III. Because of the basicity of protamine, heparin has an increased affinity for protamine relative to antithrombin III. In fact, its binding affinity for protamine is so much greater than that of antithrombin III that protamine actually will induce dissociation of the heparin/antithrombin III complex. If protamine is administered in the absence of heparin, it can have marked effects on coagulation. Protamine is not completely selective for heparin and, in vivo, also interacts with fibrinogen, platelets, and other plasma proteins causing anticoagulation. For this reason, use of the minimal amount of protamine necessary to antagonize heparin-associated bleeding should be employed (usually 1 mg of protamine intravenously for every 100 U of heparin remaining in the patient).

Side effects

Anaphylaxis also has been associated with the use of protamine. Although development of protamine anaphylaxis is not limited to diabetics, those patients with diabetes that have used protaminecontaining insulin (NPH or protamine zinc) do have a slightly increased risk of anaphylaxis. Some less common reactions to protamine include pulmonary vasoconstriction, hypotension, and thrombus formation.

PROTAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PROTAMINE manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
PROTAMINE 9012-00-4
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-08-09
Hebei Mojin Biotechnology Co., Ltd
Product
PROTAMINE 9012-00-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Jiangsu Boquan Biotechnology Co., Ltd.
Product
PROTAMINE 9012-00-4
Price
US $132.00-102.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2023-02-21

9012-00-4, PROTAMINERelated Search:


  • protamines
  • PROTAMINE
  • protamine free base grade iv
  • protamine from salmon
  • HSDB 3251
  • PROTAMINE USP/EP/BP
  • Protamine from salmon Grade IV, Histone, free(Millon test)
  • 9012-00-4
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