2'-Deoxyuridine 5'-monophosphate disodium salt

Product Name: 2'-Deoxyuridine 5'-monophosphate disodium salt
CAS No.: 42155-08-8
Chemical Name: 2'-Deoxyuridine 5'-monophosphate disodium salt
Synonyms: dump;DUMP 2NA;2'-dUMP?2Na;dUMP·（Na·salt）;D-UMP DISODIUM SALT;Diquafosol Impurity 22;Diquafosol Impurity 30;dUMP 100mM Sodium Solution;2'-Deoxyuridine 5'-monophosphate;2'-Deoxy-5'-uridylic acid disodium salt
CBNumber: CB9482517
Molecular Formula: C9H14N2NaO8P
Formula Weight: 332.18
MOL File: 42155-08-8.mol

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2'-Deoxyuridine 5'-monophosphate disodium salt Property

storage temp.: -20°C
solubility: PBS (pH 7.2): 1 mg/ml
form: Powder
color: White to Off-white
biological source: synthetic (organic)
Water Solubility: Soluble in water.
InChI: InChI=1/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;/t5-,6+,8+;;/s3
InChIKey: WXIVKKBDJOCRNB-BAJMBWAYNA-N
SMILES: O=C1NC(=O)C=CN1[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1.[NaH] |&1:8,10,12,r|
CAS DataBase Reference: 42155-08-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-37/39
WGK Germany: 3
HS Code: 29349990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D3876
Product name: 2′-Deoxyuridine 5′-monophosphate disodium salt
Purity: Sigma Grade
Packaging: 100mg
Price: $283
Updated: 2026/03/19

Sigma-Aldrich

Product number: D3876
Product name: 2′-Deoxyuridine 5′-monophosphate disodium salt
Purity: Sigma Grade
Packaging: 1g
Price: $1640
Updated: 2026/03/19

Sigma-Aldrich

Product number: D3876
Product name: 2′-Deoxyuridine 5′-monophosphate disodium salt
Purity: Sigma Grade
Packaging: 250mg
Price: $537
Updated: 2026/03/19

TRC

Product number: D281815
Product name: 2′-Deoxyuridine 5′-monophosphate disodium salt
Packaging: 250mg
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND02992
Product name: 2'-Deoxyuridine-5'-monophosphate disodium salt
Packaging: 500mg
Price: $110
Updated: 2021/12/16

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2'-Deoxyuridine 5'-monophosphate disodium salt Chemical Properties,Usage,Production

Description

2'-Deoxyuridine 5'-monophosphate disodium salt is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. 2'-Deoxyuridine 5'-monophosphate disodium salt has been shown to be effective in treating squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. 2'-Deoxyuridine 5'-monophosphate disodium salt is also used as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus.

Uses

2-Deoxyuridine 5-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

General Description

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

Biochem/physiol Actions

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

Synthesis

2'-iodouridine (5g, 14.1mmol), 10% wet palladium carbon (0.1g) and triethylamine (1.8g, 18mmol), was added to ethanol (100mL), stirred at room temperature for 30min, displacing hydrogen, maintaining hydrogen pressure in the reaction flask 1atm, stirred at room temperature for 2h, TLC showed that the reaction of the raw materials was complete, added 2g Diatomaceous earth, stirred for 10min, filtration to remove palladium carbon, filtrate concentration to get oil, and then add phosphoric acid (50mL), heating to dissolve, after cooling there is a white solid precipitation, filtration, washed to almost colorless, filter cake drying to get the crude 2'-deoxyuridine-5'-disodium monophosphate, recrystallization and filtration, drying, to get the pure product 2.96 g The product was dried and recrystallized to obtain 2.96g of pure product with 92% yield and 98% purity by HPLC.

2'-Deoxyuridine 5'-monophosphate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Deoxyuridine 5'-monophosphate disodium salt Suppliers

China 187 Germany 1 India 5 Switzerland 1 The Netherlands 1 United Kingdom 5 United States 22 Global 222

Hangzhou Meiya Pharmaceutical Co.,ltd.

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Advantage: 58

Shanghai Yingxin Laboratory Equipment Co., Ltd.

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Hongene Biotech Corporation

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Adamas Reagent, Ltd.

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Nanjing Asian Chemical Co., Ltd.

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T&W GROUP

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Beijing HuaMeiHuLiBiological Chemical

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View Lastest Price from 2'-Deoxyuridine 5'-monophosphate disodium salt manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd

Product: 2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP-Na2) 42155-08-8
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥99.0%
Supply Ability: 500 kg
Release date: 2024-02-07

Henan Aochuang Chemical Co.,Ltd.

Product: 2'-Deoxyuridine 5'-monophosphate disodium salt 42155-08-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Shaanxi Dideu Medichem Co. Ltd

Product: 2'-Deoxyuridine 5'-monophosphate disodium salt 42155-08-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

42155-08-8, 2'-Deoxyuridine 5'-monophosphate disodium saltRelated Search:

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dump

2''-Deoxyuridine-5''-monophosphoric acid disodium salt

2'-deoxyuridine 5'-monophosphate*disodium sigma G

5'-Uridylic acid, 2'-deoxy-, disodium salt

2'-Deoxyuridine-5'-monophosphate,sodiumsalt

2'-DEOXYURIDINE 5'-MONOPHOSPHATEDISODIUM SIGMA GRA

2''-DEOXYURIDINE 5''-MONOPHOSPHATE DISODIUM SALT (DUMP-NA2)

2'-Deoxy-5'-uridylic acid disodium salt

2'-Deoxyuridine 5'-(phosphoric acid disodium) salt

Sodium ((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl phosphate

dUMP, 2'-Deoxyuridine-5'-Monophosphate, disodiuM salt

DUMP 2NA

D-UMP DISODIUM SALT

2'-dUMP?2Na

dUMP·（Na·salt）

2′-Deoxyuridine5′-mono-phos-phatedisodiumsal

2'-Deoxyuridine 5'-monophosphate (disodium)

Diquafosol Impurity 22

[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl phosphate

[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate

2`-Deoxyuridine-5`-Monophosphate Disodium Salt (dUMP-Na2) extrapure, 98%

2′-Deoxyuridine-5′-monophosphate disodium salt [dUMP·(Na·salt)

Deoxyuridine 5′-monophosphate (sodium salt)

Diquafosol Impurity 30

Disodium 2'-deoxy-5'-O-phosphonatouridine

dUMP 100mM Sodium Solution

2'-Deoxyuridine 5'-monophosphate

2'-Deoxyuridine 5'-monophosphate disodium salt

2''-Deoxyuridine-5''-monophosphate disodium salt, reference substrate for dUMP analogs

dUMP·Na2, 2''-Deoxyuridine 5''-monophosphate disodium salt

2'-Deoxyuridine-5'-monophosphate disodium salt, reference substrate for dUMP analogs

dUMP.2Na (2-Deoxyuridine-5-monophosphate disodium salt)

2'-Deoxyuridine 5'-monophosphate disodium salt

42155-08-8

C9H11N2Na2O8P

C9H11N2O8PNa2

Metabolites and Cofactors on the Metabolic Pathways Chart

Metabolic Pathways

Nucleotide

Metabolomics

BioChemical

Nucleotide