ChemicalBook > CAS DataBase List > Amiloride hydrochloride dihydrate

Amiloride hydrochloride dihydrate

Product Name
Amiloride hydrochloride dihydrate
CAS No.
17440-83-4
Chemical Name
Amiloride hydrochloride dihydrate
Synonyms
Modamide;AMilorida;Amiloride hydrochlorid;AMILORIDE HCL DIHYDRATE;AMiloride hydrocholride;AMILORIDEHYDROCHLORIDE,USP;MK-870 hydrochloride dihydrate;AMILORIDE HYDROCHLORIDE (500 MG);Miloride hydrochloride dihydrate;Amiloride HCl dihydrate (MK 870)
CBNumber
CB9501409
Molecular Formula
C6H8ClN7O.HCl.2H2O
Formula Weight
302.12
MOL File
17440-83-4.mol
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Amiloride hydrochloride dihydrate Property

Melting point:
>240℃
RTECS 
UQ2275500
storage temp. 
Store at -20°C
solubility 
Slightly soluble in water and in anhydrous ethanol.
pka
8.7(at 25℃)
form 
Solid
color 
Off-white to yellow
Water Solubility 
Soluble in water at 50mg/ml
InChI
InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
InChIKey
LTKVFMLMEYCWMK-UHFFFAOYSA-N
SMILES
C1(C(NC(N)=N)=O)=NC(Cl)=C(N)N=C1N.[H]Cl.[H]O[H].[H]O[H]
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Safety

WGK Germany 
3
HazardClass 
6.1
HS Code 
2933995300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1839
Product name
Amiloride hydrochloride
Packaging
1g
Price
$230
Updated
2025/07/31
Sigma-Aldrich
Product number
1019701
Product name
Amiloride hydrochloride
Packaging
500mg
Price
$425
Updated
2025/07/31
AK Scientific
Product number
J99713
Product name
Amiloride hydrochloride dihydrate
Packaging
1g
Price
$20
Updated
2021/12/16
Oakwood
Product number
019420
Product name
3,5-Diamino-N-(aminomethyl)-6-chloropyrazine carboxamide hydrochloride dihydrate
Packaging
1g
Price
$25
Updated
2021/12/16
AK Scientific
Product number
O373
Product name
Amiloride hydrochloride dihydrate
Packaging
1g
Price
$27
Updated
2021/12/16
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Amiloride hydrochloride dihydrate Chemical Properties,Usage,Production

Chemical Properties

Pale yellow or greenish-yellow powder.

Uses

Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Uses

Diuretic;Antialdosteron

Uses

An epithelial sodium channel blocker

Definition

ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride.

brand name

Midamor (Merck).

in vivo

Amiloride hydrochloride dihydrate is a potent epithelial sodium channels (ENaCs) blocker. Amiloride is highly concentrated in the plasma 15 to 30 minutes following the injections. 2 mg/kg dose of Amiloride hydrochloride dihydrate has no effect on blood pressure, heart rate, mesenteric vascular resistance, or hindquarters vascular resistance as compare to the baseline measurements (n=7). Over a 2 hour period, Amiloride hydrochloride dihydrate elicits negligible responses in arterial pressure (-1±1 mmHg) and heart rate (-10±6 bpm/min) as compare to baseline levels. Results show an Amiloride hydrochloride dihydrate dose-related response pattern for the c-Fos activation in the area postrema (AP). Even at the lowest dose of Amiloride hydrochloride dihydrate (0.1 mg/kg), the number of c-Fos labeled neurons in the AP is statistically different from the control rats at a p<0.01 level[1].

Amiloride hydrochloride dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Amiloride hydrochloride dihydrate Suppliers

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View Lastest Price from Amiloride hydrochloride dihydrate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Amiloride hydrochloride dihydrate 17440-83-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Career Henan Chemical Co
Product
Amiloride hydrochloride dihydrate 17440-83-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-09

17440-83-4, Amiloride hydrochloride dihydrateRelated Search:

Topotecan hydrochloride alminoprofen D-Glucosamine hydrochloride N,N-Dimethylformamide Amiloride hydrochloride Benzamide Chlorantraniliprole p-Aminobenzamide Formamide 4-AMINOAZOBENZENE HYDROCHLORIDE CHARYBDOTOXIN Nicardipine hydrochloride DOTARIZINE AMILORIDE 5-(N,N-HEXAMETHYLENE)-AMILORIDE FOROXYMITHINE Amiloride hydrochloride dihydrate

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  • 17440-83-4
  • C6H8ClN7OHCl2H2O
  • C6H13Cl2N7O3
  • C6H9ClN7O
  • MK-870