Amiloride hydrochloride dihydrate
- Product Name
- Amiloride hydrochloride dihydrate
- CAS No.
- 17440-83-4
- Chemical Name
- Amiloride hydrochloride dihydrate
- Synonyms
- Modamide;AMilorida;Amiloride hydrochlorid;AMILORIDE HCL DIHYDRATE;AMiloride hydrocholride;AMILORIDEHYDROCHLORIDE,USP;MK-870 hydrochloride dihydrate;AMILORIDE HYDROCHLORIDE (500 MG);Miloride hydrochloride dihydrate;Amiloride HCl dihydrate (MK 870)
- CBNumber
- CB9501409
- Molecular Formula
- C6H8ClN7O.HCl.2H2O
- Formula Weight
- 302.12
- MOL File
- 17440-83-4.mol
Amiloride hydrochloride dihydrate Property
- Melting point:
- >240℃
- RTECS
- UQ2275500
- storage temp.
- Store at -20°C
- solubility
- Slightly soluble in water and in anhydrous ethanol.
- pka
- 8.7(at 25℃)
- form
- Solid
- color
- Off-white to yellow
- Water Solubility
- Soluble in water at 50mg/ml
- InChI
- InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
- InChIKey
- LTKVFMLMEYCWMK-UHFFFAOYSA-N
- SMILES
- C1(C(NC(N)=N)=O)=NC(Cl)=C(N)N=C1N.[H]Cl.[H]O[H].[H]O[H]
Safety
- WGK Germany
- 3
- HazardClass
- 6.1
- HS Code
- 2933995300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P321Specific treatment (see … on this label).
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PHR1839
- Product name
- Amiloride hydrochloride
- Packaging
- 1g
- Price
- $230
- Updated
- 2025/07/31
- Product number
- 1019701
- Product name
- Amiloride hydrochloride
- Packaging
- 500mg
- Price
- $425
- Updated
- 2025/07/31
- Product number
- J99713
- Product name
- Amiloride hydrochloride dihydrate
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 019420
- Product name
- 3,5-Diamino-N-(aminomethyl)-6-chloropyrazine carboxamide hydrochloride dihydrate
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- O373
- Product name
- Amiloride hydrochloride dihydrate
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
Amiloride hydrochloride dihydrate Chemical Properties,Usage,Production
Chemical Properties
Pale yellow or greenish-yellow powder.
Uses
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
Uses
Diuretic;Antialdosteron
Uses
An epithelial sodium channel blocker
Definition
ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride.
brand name
Midamor (Merck).
in vivo
Amiloride hydrochloride dihydrate is a potent epithelial sodium channels (ENaCs) blocker. Amiloride is highly concentrated in the plasma 15 to 30 minutes following the injections. 2 mg/kg dose of Amiloride hydrochloride dihydrate has no effect on blood pressure, heart rate, mesenteric vascular resistance, or hindquarters vascular resistance as compare to the baseline measurements (n=7). Over a 2 hour period, Amiloride hydrochloride dihydrate elicits negligible responses in arterial pressure (-1±1 mmHg) and heart rate (-10±6 bpm/min) as compare to baseline levels. Results show an Amiloride hydrochloride dihydrate dose-related response pattern for the c-Fos activation in the area postrema (AP). Even at the lowest dose of Amiloride hydrochloride dihydrate (0.1 mg/kg), the number of c-Fos labeled neurons in the AP is statistically different from the control rats at a p<0.01 level[1].
Amiloride hydrochloride dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Amiloride hydrochloride dihydrate manufacturers
- Product
- Amiloride hydrochloride dihydrate 17440-83-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-19
- Product
- Amiloride hydrochloride dihydrate 17440-83-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09