2-CHLOROLEPIDINE

2-CHLOROLEPIDINE Property

Melting point:

55-58 °C(lit.)

Boiling point:

296 °C(lit.)

Density 

1.1810 (rough estimate)

refractive index 

1.6224 (estimate)

Flash point:

296°C

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

0.98±0.50(Predicted)

color 

White to Almost white

BRN 

118333

InChI

InChI=1S/C10H8ClN/c1-7-6-10(11)12-9-5-3-2-4-8(7)9/h2-6H,1H3

InChIKey

PFEIMKNQOIFKSW-UHFFFAOYSA-N

SMILES

N1C2C(=CC=CC=2)C(C)=CC=1Cl

CAS DataBase Reference

634-47-9(CAS DataBase Reference)

NIST Chemistry Reference

Quinoline, 2-chloro-4-methyl-(634-47-9)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36-24/25

WGK Germany 

3

HS Code 

29334900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-CHLOROLEPIDINE Chemical Properties,Usage,Production

Description

4-Methyl-2-chloro-quinoline is an organic intermediate. It has been reported that it can be used to prepare graphite electrodes based on CrO-FeO-PbO and quinoline modified and a modified vermiculite adsorbent for the adsorption and removal of benzene in chemical wastewater.

Preparation

The mixture of 2-hydroxy-4-methylquinoline and phosphorus oxychloride was heated to 80-85°C. After the solid was completely dissolved, the mixture was poured into ice water, the mixture was extracted with ether, and the ether extract was distilled out of ether. Afterwards, carry out vacuum distillation, collect 132-135 ℃ (0.4kPa) fraction, namely 2-chloro-4-methylquinoline. For further purification, petroleum ether (boiling point 40-50°C) can be used for recrystallization, and the yield is 86%-89%.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-4-methyl-quinoline is a useful synthetic intermediate. It is an intermediate used to synthesize 4-Methyl-2-(1-piperidinyl)-quinoline (M320715) which is a potent inhibitor of TRPC4 channels, responsible for various stimulation, muscle response due to interaction with the environment. 2-Chloro-4-methyl-quinoline is also considered as a cyanine dye.

Synthesis Reference(s)

Journal of the American Chemical Society, 63, p. 2367, 1941 DOI: 10.1021/ja01854a016
Organic Syntheses, Coll. Vol. 3, p. 194, 1955

Synthesis

General method: 4-Methylquinoline-N-oxide (1.0 eq.) was dissolved in anhydrous dichloromethane (0.1 M) at 0 °C. Phosphorous trichloride (1.2 eq.) was added slowly with stirring, followed by the addition of N,N-dimethylformamide (0.5 eq.) dropwise under argon protection. The reaction mixture was gradually warmed to 25 °C with continuous stirring until the reaction was complete (monitored by TLC). After completion of the reaction, saturated aqueous sodium carbonate solution was slowly added and the pH was adjusted to 7~8. The aqueous phase was extracted with dichloromethane, the organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to obtain the crude product. The crude product was purified by fast column chromatography using petroleum ether/ethyl acetate (80:1) as eluent to obtain 2-chloro-4-methylquinoline.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 51, p. 7130 - 7132