3-Amino-2(1H)-pyridinone
Uses- Product Name
- 3-Amino-2(1H)-pyridinone
- CAS No.
- 33630-99-8
- Chemical Name
- 3-Amino-2(1H)-pyridinone
- Synonyms
- 3-Amino-2-pyridinone;3-Amino-2-pyridone;3-Amino-2-pyridinol;3-AMINO-PYRIDIN-2-OL;3-Amino-2-pyridone >3-Amino-2-pyridinol,97%;3-Amino-2(1H)-pyridinone;3-amino-1H-pyridin-2-one;3-Amino-2-hydroxypyridine;2-HYDROXY-3-AMINO PYRIDINE
- CBNumber
- CB9664184
- Molecular Formula
- C5H6N2O
- Formula Weight
- 110.11
- MOL File
- 33630-99-8.mol
3-Amino-2(1H)-pyridinone Property
- Melting point:
- 118-130 °C
- Boiling point:
- 206.4°C (rough estimate)
- Density
- 1.2111 (rough estimate)
- refractive index
- 1.4800 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Powder
- pka
- 13.87±0.10(Predicted)
- color
- Dark brown to black
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C5H6N2O/c6-4-2-1-3-7-5(4)8/h1-3H,6H2,(H,7,8)
- InChIKey
- VTSFNCCQCOEPKF-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=CC=C1N
- CAS DataBase Reference
- 33630-99-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 37/39-26-36
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS007860
- Product name
- 3-amino-2-hydroxypyridine
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $107
- Updated
- 2025/07/31
- Product number
- A2285
- Product name
- 3-Amino-2-pyridone
- Purity
- >96.0%(GC)(T)
- Packaging
- 1g
- Price
- $104
- Updated
- 2025/07/31
- Product number
- A2285
- Product name
- 3-Amino-2-pyridone
- Purity
- >96.0%(GC)(T)
- Packaging
- 5g
- Price
- $415
- Updated
- 2025/07/31
- Product number
- A611160
- Product name
- 3-Amino-2-hydroxypyridine
- Packaging
- 10g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 4H56-1-VP
- Product name
- 3-Aminopyridin-2(1H)-one
- Packaging
- 100g
- Price
- $949
- Updated
- 2021/12/16
3-Amino-2(1H)-pyridinone Chemical Properties,Usage,Production
Uses
3-Amino-2-hydroxypyridine has been used as a reactant in the preparation of benzothiazolyl hydroxyindolinylphenyl ureas as potent P2Y1 antagonists.
Chemical Properties
Brown to off-white crystalline powder.
Uses
It is used as pharmaceutical intermediate. It is involved in synthesis of functionalized pyrido[4,3-b][1,4]oxazine and imidazo[1,2-a]pyridine derivatives. The use of ethyl 2-chloro-3-oxopropanoate with 2-amino-3-hydroxypyridine or 3-amino-4-hydroxypyridine led, respectively, to imidazo[1,2-a]pyridine derivatives or ethyl pyrido[4,3-b][1,4] oxazine-2-carboxylate.
Synthesis
6332-56-5
33630-99-8
a) Synthesis of 3-aminopyridin-2-ol: In a 500 mL three-necked flask, 3-nitropyridin-2(1H)-one (1 g, 7.14 mmol) was dissolved in methanol (200 mL), followed by addition of 10% palladium/activated carbon catalyst (100 mg, 10 wt%). The reaction mixture was stirred for 3 h under hydrogen atmosphere (1 atm) and at room temperature (25°C). Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad, and the filtrate was concentrated under reduced pressure by rotary evaporator to afford the white solid product 3-aminopyridin-2-ol (800 mg, quantitative yield). Product characterization data: 1H-NMR (CD3OD, 300 MHz) δ 6.78-6.73 (m, 2H), 6.23 (t, J = 6.5 Hz, 1H); MS (ESI) m/z 111.1 [M+H]+.
References
[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 14
[2] Patent: WO2006/51410, 2006, A1. Location in patent: Page/Page column 46
[3] Heterocycles, 1990, vol. 31, # 12, p. 2201 - 2204
[4] Heterocycles, 1990, vol. 31, # 12, p. 2201 - 2204
[5] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 1013,1024
3-Amino-2(1H)-pyridinone Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-2(1H)-pyridinone Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 3-Amino-2(1H)-pyridinone manufacturers
- Product
- 3-Amino-2(1H)-pyridinone 33630-99-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-14
- Product
- 3-Amino-2(1H)-pyridinone 33630-99-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- 3-Amino-2-pyridinol 33630-99-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 90%-99.9%
- Supply Ability
- 500kg
- Release date
- 2019-07-12