Amitraz

Overview Indication and contradiction Pharmacokinetics and pharmacodynamic Reference

Product Name: Amitraz
CAS No.: 33089-61-1
Chemical Name: Amitraz
Synonyms: bipin;baam;imidamide;ZAMIR;RACET;ISOKA;MITAC;SENDER;TAKTIC;BYEBYE
CBNumber: CB9680920
Molecular Formula: C19H23N3
Formula Weight: 293.41
MOL File: 33089-61-1.mol

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Amitraz Property

Melting point:: 86-87°C
Boiling point:: 425.25°C (rough estimate)
Density: 1.1280
vapor pressure: 3.4×10^-4 Pa (25 °C)
refractive index: 1.5892 (estimate)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml
pka: 4.2 (weak base)
Water Solubility: 0.08 mg l^-1
form: Powder/Solid
color: White
λmax: 247nm(lit.)
Merck: 14,486
InChIKey: QXAITBQSYVNQDR-ZIOPAAQOSA-N
CAS DataBase Reference: 33089-61-1(CAS DataBase Reference)
NIST Chemistry Reference: Amitraz(33089-61-1)
EPA Substance Registry System: Amitraz (33089-61-1)

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Safety

Hazard Codes: Xn;N,N,Xn
Risk Statements: 22-43-48/22-50/53
Safety Statements: 22-24-36/37-60-61
RIDADR: UN 3077
WGK Germany: 3
RTECS: ZF0480000
HazardClass: 9
PackingGroup: III
HS Code: 29252900
Hazardous Substances Data: 33089-61-1(Hazardous Substances Data)
Toxicity: LD50 in male rats, female mice, rabbits, guinea pigs, bobwhite quail (mg/kg): 800, >1600, >100, >400, 788 orally; LD50 in rabbits, male rats (mg/kg): >200, >1600 dermally; LC50 (48 hr) in rainbow trout, Japanese carp: 3.3, 1.2 ppm (Labonne)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 45323
Product name: Amitraz
Purity: PESTANAL
Packaging: 250mg
Price: $36.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1028000
Product name: Amitraz
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $412
Updated: 2024/03/01

TCI Chemical

Product number: A2608
Product name: Amitraz
Packaging: 250MG
Price: $38
Updated: 2024/03/01

TCI Chemical

Product number: A2608
Product name: Amitraz
Packaging: 1G
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 28852
Product name: Amitraz
Purity: ≥98%
Packaging: 100 mg
Price: $29
Updated: 2024/03/01

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Amitraz Chemical Properties,Usage,Production

Overview

Amitraz is a formamidine pesticide widely used as an insecticide and acaricide. Formamidine pesticides were developed in the late 1950s and early 1960s due to the development of resistances to conventional insecticides. The two formamidines primarily marketed and most widely used are chlordimeform and amitraz. Amitraz (1,5-di (2,4-dimethylphenyl)-3-methyl-1, 3, 5-triazapenta1,4-diene) (Figure 1) was first patented in 1971, registered as a pesticide of technical grade in 1975^[1] and marketed in 1981.
Amitraz is an insecticide used to prevent tick and mite infestation and is in common use around the world. Amitraz is applied to cattle^[2] and sheep in dip baths at concentrations of 0.025%^[3], to dogs from collars impregnated with 0.025% amitraz, or by topical application in a bath of 0.05% amitraz^[4], to pigs in sprays containing 12.5%, and to cotton and hops^[5] by spraying 20% solutions of amitraz from aeroplanes and ground sprinklers. In addition, amitraz is used to control psylla infestations of pears^[6]. Human exposure to amitraz occurs when diluting the concentrate obtained from the manufacturer, when applying the amitraz to crops or animals, and when working in amitraz-treated areas, for example pear orchards or cotton fields^[1].
Different agencies have evaluated amitraz toxicity and the lethal dose 50 (LD50) or lethal concentration 50(LC50) values on acute toxicity studies^{[1, 7]}. The EPA (Environmental Protection Agency), according to acute toxicity studies, classifies amitraz as Class III-slightly toxic by the oral and inhalation routes, as Class II-moderately toxic by the dermal route, and as Class IV-not a dermal irritant and only slightly irritant to the eyes and not a dermal sensitizer^[1].
Amitraz is rapidly absorbed, distributed, metabolized, and eliminated primarily via urine when administered orally to mammals.^{[1, 7]} No differences have been described between species and genders in the rates and routes of excretion. In all species studied, 55−74% of the dose was excreted in the urine within the first 24 h after dosing^{[1, 7]}. The degradation products present in the urine include N′-[2,4-dimethylphenyl]-Nmethylformamidine (BTS-27271), 2,4-dimethylformanilide (BTS-27919), 2,4-dimethylaniline (BTS-24868), 4-formamido3-methylbenzoic acid (BTS-39098), 4-amino-3-methylbenzoic acid (BTS-28369), and several unknown metabolites.^[8] Moreover, the spectrum of metabolites observed was similar in all species studied. BTS-27271 and BTS-27919 are the main metabolites of amitraz and a cause of concern due to the content of the 2,4-dimethylaniline moiety, which could lead to developmental and genotoxic effects.^{[1, 2]} Furthermore, BTS-27271 has been found to be more potent than amitraz with regard to its miticidal activity and mammalian toxicity. The action of these metabolites has been described only for some of the mechanisms and effects of amitraz; thus, further studies are needed to determine their participation in the rest of the mechanisms and effects^{[9, 10]}.

Figure 1 the chemical structure of amitraz

Indication and contradiction

Amitraz is indicated for animal use against mites, lice and ticks for cattle, swine and sheep. For dogs, it is used against ticks and mite^[11]. It was reported as the drug of choice in the treatment of localized and generalized demodicosis in dogs^[11]. Along with macrocyclic lactones such as milbemycin oxime, ivermectin, moxidectin, and doramectin, amitraz is still recommended for the treatment of generalized canine demodicosis, although it is not very efficient in adult-onset demodicosis cases^[12]. Chesney (1989) also reported the use of amitraz in the treatment of demodicosis in cats[13]. Gunaratnam et al. (1983)^[14] evaluated amitraz toxicity in cats, and concluded that low concentrations, around 0,0125% are capable of generating moderate toxic effects, especially anorexia. The toxic effects are even more evident in cats, due to their licking habit, resulting in a higher intake of the product. However, it is possible to use amitraz topically in healthy cats, respecting the appropriate contraindications common to the other species, which is to avoid the use in diabetic, hypothermic, and cardiac patients.
Amitraz is contraindicated in horses due to the risk of hypomotility and intestinal atony, leading to severe intestinal impaction^{[13, 14]}. It has been also observed, besides the intestinal symptoms, the occurrence of neurologic signs as drowsiness, decreased cranial nerve reflexes and ataxia in horses submitted to the experimental use of amitraz. This substance is contraindicated for patients with extended skin injuries, which could lead to an over absorption, favoring intoxication.

Pharmacokinetics and pharmacodynamic

Amitraz is quickly hydrolyzed in an acid environment when it is orally administrated, due to its instability in this environment. The hydrolysis in a low pH generates the compound 2,4-dimethylphenyl formamide, which is stable in an acid environment. This substance can still be hydrolyzed, generating 2,4-dimethylaniline^[15]. Absorption is effective through the skin, which may be major or minor depending on its integrity, the occurrence of injuries, and inflammation. After reaching the blood stream, the drug reaches the highest plasmatic level in up to two hours. The biotransformation occurs in the liver, generating the active metabolite BTS 27271, the most important pharmacologically, because it acts directly in the regulation of the insulin and glucagon secretion by binding to the α2A and α2D-adrenergic receptors, inhibiting insulin and stimulating glucagon secretion, resulting in hyperglycemia. Metabolites are excreted in bile and urine.
In insects, formamidines such as chlordimeform and amitraz operate its toxic effects by interacting with octopaminergic receptors in the central nervous system^[16]. The mechanisms by which the deleterious effects of amitraz in mammals are determined are based on its agonistic action on α2-adrenergic receptors and inhibitory action over the monoamine oxidase (MAO), but there are reports of various action pathways, such as: H1 histamine receptor inhibition, prostaglandin synthase inhibition, adenylyl cyclase inhibition, voltage-gated calcium channels activation, reactive oxygen species generation, cell death induction and endocrine disruptions. Amitraz is also related to the emergence of neurotoxic effects and modifications in the reproductive sphere in rats^[17].

Reference

USEPA (United States Environmental Protection Agency) (1996)
McDougall K and Lewis I (1984). Aust Vet J 61,137–140.
Eamens G, Spence S and Turner M (2001) Aust Vet J 79,703–706.
Shaw S and Foster A (2000) Aust Vet J 78,243–244.
Weichel L and Nauen R (2003) Pest Manage Sci 59,991–998.
Schaub L, Sardy S and Capkun G (2002) Pest Manage Sci 58,959–963.
JMPR. Pesticide Residues in Food−1998, Evaluations Part II: Toxicological WHO/PCS/99.18, 1998
Knowles, C. O., and Benezet, H. J. (1981) J. Environ. Sci. Health, Part B 16, 547−555.
Schuntner, C. A., and Thompson, P. G. (1978) Aust. J. Biol. Sci. 31, 141−148.
Pass, M. A., and Mogg, T. D. (1991) Comp. Biochem. Physiol., Part C: Pharmacol., Toxicol. Endocrinol. 99, 169−172.
Folz, S.D et al. Veterinary Parasitology, 16(3-4): 335–341, 1984.
Mueller, R.S. Veterinary Dermatology, 15: 75-89, 2004
Chesney, C.J. Journal of Small Animal Practice, 30(12): 689-695, 1989
Gunaratnam, P.; Wilkinson, G.T.; Seawright, A.A. Australian Veterinary Journal, 60(9): 278–279, 1983.
Pierpoint, A.C.; Hapeman, C.J.; Torrents, A. Journal of Agricultural and Food Chemistry's. 45(5): 1937-1939,1997.
Chen, A.C.; He, H.; Davey, R.B. Veterinary Parasitology, 148: 379-383, 2007.
Del Pino, J.; et al Chemical Research in Toxicology, 28(6): 1073-1094, 2015.
Costa, L. G., Wu, D. S., Olibet, G., and Murphy, S. D. (1989) Neurotoxicol. Teratol. 11, 405−411.
Douglas, W. W. (1980) Histamine and 5-Hydroxytryptamine (Serotonin) and Their Antagonist, in The Pharmacological Basis of Therapeutics., pp 609−646, Macmillan, New York.
Levitt, P., et al. (1997) Trends Neurosci. 20, 269−274.
Fajardo, A. M., et al (2014) Cancers 6, 436−458.
Shin, D. H., and Hsu, W. H. (1994) Toxicol. Appl. Pharmacol. 128, 45−49.
Radakovic, M., et al J. Biosci. (New Delhi, India) 38, 53−62.
Gregorc, A., and Bowen, I. D. (2000) Cell Biol. Int. 24, 319−324.

Chemical Properties

Beige to Pale Yellow Solid

Chemical Properties

Amitraz forms colorless needle-like crystals. Liquid formulations may contain flammable organic solvents.

Originator

Aludex,Hoechst Roussel Vet Ltd.

Uses

Amitraz is used for the control of all stages of mites and insects such as aphids and whitefly, and the eggs and first instar larvae of Lepidoptera on fruit, cotton and vegetables. It is also used in honey bee hives and for the control of ticks, mites and lice on domestic and farm animals.

Uses

coccidiostat, antiplatelet

Uses

Amitraz is an antiparasitic used to control red spider mites, leaf miners and scale insects. This compound is active by inhibiting the targets monoaminooxidase enzyme.

Uses

Acaricide; insecticide.

Definition

ChEBI: A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.

Manufacturing Process

A mixture of 55.1 g 2,4-dimethylaniline hydrochloride, 83.7 g ptoluenesulphonyl chloride and 150 ml N-methylformamide was stirred with occasional cooling to maintain the temperature at 20°-35°C. When the exothermic reaction had subsided, the mixture was stirred at room temperature for 4 h, poured into a mixture of ice and water, and basified with 10 N sodium hydroxide solution, keeping the temperature of the mixture below 10°C. The precipitated solid was filtered, washed with water until free from alkali, dried at room temperature, to give N-2,4-dimethylphenyl-N'- methylformamidine, melting point 75°-76°C (recrystallized from cyclohexane).
A solution of 19.4 g N-2,4-dimethylphenyl-N'-methylformamidine and 0.3 g ptoluenesulphonic acid in 195 ml dry xylene was refluxed under anhydrous conditions for 48 h, causing the evolution of methylamine. The xylene was distilled off under reduced pressure to give 1,5-di-(2,4-dimethylphenyl)-3- methyl-1,3,5-triaza-penta-1,4-diene, melting point 88°-89°C (crystallized twice from isopropyl).

Therapeutic Function

Acaricide, Scabicide, Tickicide, Appetite stimulant

General Description

White monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Unstable in acid.

Agricultural Uses

Insecticde, Acaricide, Veterinary medicine: Registered for control of pear psylla on pears, whitefly and mites on pears and cotton; cattle, dogs, sheep, and hog dip to control ticks, mange mites, lice and other pests. Not permitted on apples. Used to control red spider mites, leaf miners, scale insects, and aphids. Also used on cotton to control bollworms, white fly, leaf worms, and tobacco budworms. Not registered for use in EU countries

Trade name

AAZDIENO®; ACARAC®; ACADREX®; ARMY®; AZODIENO®; BAAM®; BOOTS BTS 27419®; BTS 27,419®; BUMETRAN®; COYOTE®; DANICUT®; ECTODEX®; EDRIZAN®; EDRIZAR®; GARIAL®; ISTAMBUL®; MITABAN®; MITAC®; OVASYN®; OVIDREX®; PARSEC®; ROTRAZ®; SENDER®; TAC-PLUS®; TACTIK®; TRIATIX®; TRIATOX®; TUDY®; VAPCOZIN TAKTIC®; UPJOHN U-36059®

Pharmacology

The mechanism of action of amitraz has not been completely elucidated, and, presently, a dual mode of action appearsmost likely. Firstly, the enzymemonoamine oxidase, which metabolizes neurotransmitter amines in mites and ticks, is inhibited. Secondly, octopamine receptors in the central nervous system of ectoparasites are activated by amitraz, thereby modifying tonic muscle contractions. The effect of amitraz is to induce increased neuronal activity, abnormal behavior, detachment, and death of mites and ticks.

Potential Exposure

Those engaged in the manufacture, formulation and application of this insecticide and acaricide. A rebuttable presumption against registration for amitraz was issued on April 6, 1977 by United States Environmental Protection Agency on the basis of oncogenicity. Incompatibilities: Keep away from strong oxidizers and strong acids. Acids may render this material unstable.

Veterinary Drugs and Treatments

In dogs, amitraz solution is used topically primarily in the treatment of generalized demodicosis. A topical spot-on solution (ProMeris? for Dogs) and a collar (Preventic?) are available for treatment and prevention of flea and tick infestation. It is also used as a general insecticidal/ miticidal agent in several other species (see label information). The pharmacologic action of amitraz is not well understood, but it is a monoamine oxidase (MAO) inhibitor (in mites) and may have effects on the CNS of susceptible organisms. It apparently also possesses alpha-2 adrenergic activity and inhibits prostaglandin synthesis. Amitraz can cause a significant increase in plasma glucose levels, presumably by inhibiting insulin release via its alpha2-adrenergic activity. Yohimbine (alpha2 blocker) or atipamezole can antagonize this effect.

Metabolic pathway

14C-Amitraz is applied on lemons grown under glasshouse conditions at final harvest and the applied radioactivity is quantitatively recovered, predominantly in the peel (86%). The total residue at harvest contains amitraz, N-methyl-N'-(2,4-xylyl)formamidine, and formyl-2',4'-xylydine and conjugates of 4-amino- m-toluic acid and the conjugated metabolites which are convertible to 2,4-xylidine. Amitraz is readily hydrolyzed at low pH values, forming acid-stable formyl-2,4-xylydine which can be further hydrolyzed to 2,4-xylidine.

Metabolism

Amitraz is poorly absorbed when applied topically to animals. By contrast, orally administered amitraz is rapidly and extensively absorbed. The metabolism and excretion of amitraz are also rapid. It is hydrolyzed to N-(2,4-dimethylphenyl)-N -methyl formamidine and 2,4- dimethyl formamidine and the final product, 4-amino-3- methylbenzoic acid, is converted to non-toxic conjugates. The latter are excreted in the urine and, to a lesser extent, in bile.

Shipping

UN2763 Triazine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Degradation

Amitraz is readily hydrolysed at acidic pH but is relatively stable under alkaline conditions. Its DT₅₀ values at 25 °C at pH 5,7 and 9 are given as 2.1,22.1 and 25.5 hours, respectively (PM). A recent study (Pierpoint et aE., 1997) as part of the development of a vat management and waste disposal programme for animal dips describes the kinetics and mechanism of hydrolysis of amitraz in detail. Pseudo-first-order rate constants are given for six pH values between 3.24 and 9.12. The DT₅₀ values at pH values 3.24, 5.09 and 9.12 were respectively 0.4, 8.7 and 112 hours. The reaction was mainly acid-catalysed with a small unassisted component. There was no base catalysis. One of the primary products (Scheme 1) was N-2,4 dimethylphenyl-N-methylformamidine( 2); however, at low pH this was not detected because it was rapidly hydrolysed to 2,4-dimethylphenylformamide (3). Some direct hydrolysis of amitraz to product 3 was also seen. The latter underwent slow base-catalysed hydrolysis to 2,4 dimethylaniline (4). This was a much slower reaction with a DT₅₀ (pH 9.12) of about 300 days.

Toxicity evaluation

Amitraz displays serotonin (5-hydroxytryptamine) blocking activity and a2-adrenoceptor agonist activity in animals. The clinical signs associated with intoxication in dogs include sedation, bradycardia, hypotension, hyperglycaemia, hypothermia, and mydriasis. The specific antidote for animal toxicity is the a2-adrenoceptor antagonist, yohimbine. The toxicity profile of amitraz in the horse includes transient sedation and intestinal stasis that can progress to impaction colic (79). For this reason, amitraz is not approved for use in this species in any country.

Incompatibilities

Those engaged in the manufacture, formulation and application of this insecticide and acaricide. A rebuttable presumption against registration for amitraz was issued on April 6, 1977 by United States Environmental Protection Agency on the basis of oncogenicity. Incompatibilities: Keep away from strong oxidizers and strong acids. Acids may render this material unstable.

Waste Disposal

In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Amitraz Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Triethyl orthoformate Cyclohexane Urethane Methylamine m-Xylene Water Tosyl chloride N-2,4-DIMETHYLPHENYL-N'-METHYLFORMAMIDINE 2,4-Dimethyl aniline Benzonitrile N-Methylformamide 2,4-Dimethylaniline hydrochloride

Preparation Products

AMITRAZ METABOLITE HYDROCHLORIDE Hexazinone

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33089-61-1, AmitrazRelated Search:

N,N-Dimethylacetamide Methylparaben Poly(dimethylsiloxane) Kresoxim-methyl Thiophanate-methyl Chlorodimethylphenylsilane N,N'-Methylenebisacrylamide ALMITRINE N,N-Dimethylaniline N,N-Dimethyl-1,4-phenylenediamine METSULFURON METHYL Bensulfuron methyl Methyl acrylate Methyl acetate Acetamiprid Dimethyl sulfone N,N-Dimethylformamide Dimethyl sulfoxide

33089-61-1 Amitraz 12.5% ec in veterinary medicine

n’-(2,4-dimethylphenyl)-n-(((2,4-dimethylphenyl)imino)methyl)-n-methylmethan

N’-(2,4-Dimethylphenyl)-N-[[(2,4-dimethylphenyl-imino]methyl]-N-methylmethanimidamide,N-Methylbis(2,4-xylyliminoethyl)amine

n-methyl-bis(2,4-xylyliminomethyl)amine

r.d.27419

TAKTIC

SENDER

RACET

U-36059

ZAMIR

amitraze

amitrazestrella

azadieno

azaform

baam

bipin

bootsbts27419

ectodex

fumilata

imidamide

methanimidamide,n’-(2,4-dimethylphenyl)-n-(((2,4-dimethylphenyl)imino)methyl

mitaban

n,n’-((methylimino)dimethylidyne)di-2,4-xylidine

n,n’-(methyliminodimethylidyne)bis-4-xylidine

n,n-bis(2,4-xylyliminomethyl)methylamine

N,N-di-(2,4-Xylyliminomethyl)methylamine

1,5-di(2,4-dimethylphenyl)-3-methyl-1,3,5-triazapenta-1,4-diene

BTS 27419

BAAM(R)

AURORA KA-686

ISOKA

BYEBYE

ENT 27967

EDRIZAR

methyl-bis(2,4-xylyliminomethyl)amine

AMITAC

AMITRAZ

Triatox

Triazid

AMITRAZ, 250MG, NEAT

AMITRAZ PESTANAL (N-METHYLBIS- (2,4-XYLY

BATE CYPERMETHRINE + DIMETHOATE, AMITRAZ

Methanimidamide, N-(2,4-dimethylphenyl)-N-(2,4-dimethylphenyl)iminomethyl-N-methyl-

amitraz (bsi,iso,ansi,ban,jmaf)

amitraz (ISO) N,N-bis(2,4-xylyliminomethyl) methylamine

MONOAMITRAZ

2-methyl-1,3-di(2,4-xylylimino)-2-azapropane

acarac

Biformamidine

upjohnu-36059

MITAC

MITAC(R)

PARSEC

N'-N'-[(METHYLIMINO)-DIMETHYLIDINE]-BIS-(2,4-XYLIDINE)

N-METHYL-N'-2,4-XYLYL-N-(N-2,4-XYLYLFORMIMIDOYL)-FORMAMIDINE

N,N'-(Methyliminodimethyl(idyne))bis-2,4-xylidine

1,5-BIS(2,4-DIMETHYLPHENYL)-3-METHYL-1,3,5-TRIAZAPENTA-1,4-DIENE

N'-(2,4-dimethylphenyl)-N-[(2,4-dimethylphenyl)iminomethyl]-N-methyl-formamidine