3-AMINO-4-PYRIDINECARBOXAMIDE
- Product Name
- 3-AMINO-4-PYRIDINECARBOXAMIDE
- CAS No.
- 64188-97-2
- Chemical Name
- 3-AMINO-4-PYRIDINECARBOXAMIDE
- Synonyms
- 3-Amino-isonicotimide;3-AMINOISONICOTINAMIDE;Olutasidenib Impurity 31;3-aMino-4-carbaMoylpyridine;3-Aminopyridin-4-carboxamide;3-AMINO-4-PYRIDINECARBOXAMIDE;3-Aminoisopyridin-3-carboxamide;4-Pyridinecarboxamide, 3-amino-;methyl 3-aminoisonicotinate (en);4-Pyridinecarboxamide,3-amino-(9CI)
- CBNumber
- CB9696536
- Molecular Formula
- C6H7N3O
- Formula Weight
- 137.14
- MOL File
- 64188-97-2.mol
3-AMINO-4-PYRIDINECARBOXAMIDE Property
- Melting point:
- 84-86°
- Boiling point:
- 369.2±22.0 °C(Predicted)
- Density
- 1.323±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.73±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A604793
- Product name
- 3-Aminoisonicotinamide
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A12440
- Product name
- 3-Aminopyridine-4-carboxamide
- Purity
- 92%
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- OR2138
- Product name
- 3-Aminoisonicotinamide
- Packaging
- 250mg
- Price
- $38
- Updated
- 2021/12/16
- Product number
- 4H48-1-H3
- Product name
- 3-Aminoisonicotinamide
- Packaging
- 250mg
- Price
- $42
- Updated
- 2021/12/16
- Product number
- FA54432
- Product name
- 3-Aminopyridine-4-carboxamide
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
3-AMINO-4-PYRIDINECARBOXAMIDE Chemical Properties,Usage,Production
Synthesis
7579-20-6
64188-97-2
General procedure for the synthesis of 3-aminoisonicotinamide from 3-aminoisonicotinic acid: ammonium hydrochloride (4.98 g, 93.2 mmol) was mixed with 3-aminoisonicotinic acid (9.90 g, 71.7 mmol) to which was added 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1 ,1,3,3-tetramethylene diuronium hexafluorophosphate (V) ( 35.4 g, 93.2 mmol) and N-ethyl-N-isopropylpropan-2-amine (37.5 mL, 215.02 mmol) in a solution of DMF (100 mL). The reaction mixture was stirred at 40 °C for 72 h under nitrogen protection. After completion of the reaction, the solvent was removed by evaporation to give the crude product. The crude product was purified by fast silica gel column chromatography using a gradient elution with a dichloromethane solution of 5% methanol. The purified grades were collected and evaporated to dryness to give 3-aminoisonicotinamide (8.57 g, 87% yield) as a yellow gel.
References
[1] Synthesis (Germany), 2016, vol. 48, # 8, p. 1226 - 1234
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 5, p. 1623 - 1642
[3] Patent: WO2013/12915, 2013, A1. Location in patent: Paragraph 00674-00676
[4] European Journal of Medicinal Chemistry, 2018, vol. 152, p. 235 - 252
[5] Patent: WO2007/117161, 2007, A1. Location in patent: Page/Page column 24-25
3-AMINO-4-PYRIDINECARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-AMINO-4-PYRIDINECARBOXAMIDE Suppliers
- Tel
- --
- Fax
- --
- info@rihachem.com
- Country
- Czech Republic
- ProdList
- 258
- Advantage
- 54
View Lastest Price from 3-AMINO-4-PYRIDINECARBOXAMIDE manufacturers
- Product
- 3-AMINO-4-PYRIDINECARBOXAMIDE 64188-97-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19