ChemicalBook > CAS DataBase List > 3-Pyridineacrylic acid

3-Pyridineacrylic acid

Product Name
3-Pyridineacrylic acid
CAS No.
1126-74-5
Chemical Name
3-Pyridineacrylic acid
Synonyms
3-(3-PYRIDYL)ACRYLIC ACID;Pyridine-3-acrylic acid;AKOS AUF2066;RARECHEM BK HC S246;3-Pyridineacrylicaci;3-PYRIDYLACRYLIC ACID;3-PYRIDINEACRYLIC ACID;3-Pyridylpropionic acid;3-PYRIDINYL-ACRYLIC ACID;B-(3-PYRIDYL)ACRYLIC ACID
CBNumber
CB9699461
Molecular Formula
C8H7NO2
Formula Weight
149.15
MOL File
1126-74-5.mol
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3-Pyridineacrylic acid Property

Melting point:
232-235 °C (dec.)(lit.)
Boiling point:
270.21°C (rough estimate)
Density 
1.2517 (rough estimate)
refractive index 
1.5320 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
3.13±0.10(Predicted)
form 
Solid
color 
White
InChI
InChI=1S/C8H7NO2/c10-8(11)4-3-7-2-1-5-9-6-7/h1-6H,(H,10,11)
InChIKey
VUVORVXMOLQFMO-UHFFFAOYSA-N
SMILES
C(O)(=O)C=CC1=CC=CN=C1
CAS DataBase Reference
1126-74-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-37/39-36/37/39
WGK Germany 
3
F 
10
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P1157
Product name
3-(3-Pyridyl)acrylic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
P1157
Product name
3-(3-Pyridyl)acrylic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$106
Updated
2025/07/31
TRC
Product number
P991285
Product name
3-PyridineacrylicAcid
Packaging
2.5g
Price
$110
Updated
2021/12/16
Matrix Scientific
Product number
038635
Product name
(2E)-3-Pyridin-3-ylacrylic acid
Packaging
25g
Price
$126
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK262517
Product name
3-(3-Pyridyl)acrylic Acid
Purity
98%
Packaging
25g
Price
$222
Updated
2021/12/16
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3-Pyridineacrylic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

3-Pyridineacrylic Acid is an inhibitor of peptidylglycine amidating monooxygenase.

Synthesis

100390-47-4

19337-97-4

To a solution of butyl 3-(pyridin-3-yl)prop-2-enoate (70 g, 341 mmol, 1.00 equiv) in ethanol (150 mL) was added a solution of potassium hydroxide (40 g, 712.94 mmol, 2.09 equiv) in water (150 mL). The reaction mixture was stirred at room temperature for 20 hours. Upon completion of the reaction, the pH of the solution was adjusted to 6 with 12 M hydrochloric acid.The precipitate was collected by filtration to give 50 g (98% yield) of trans-3-(3-pyridyl)acrylic acid as an off-white solid.LCMS analysis (Method C, electrospray ionization, m/z): retention time = 0.78 min, m/z = 149.9 [M+H]+.

References

[1] Patent: WO2014/74715, 2014, A1. Location in patent: Paragraph 0170
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 770 - 792

3-Pyridineacrylic acid Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Toluene Tetrahydrofuran 3-Pyridyl bromide Pyridine n-Butyllithium Malonic acid

Preparation Products

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View Lastest Price from 3-Pyridineacrylic acid manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
3-Pyridineacrylic acid 1126-74-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2000
Release date
2025-06-11
Shaanxi Dideu Medichem Co. Ltd
Product
3-Pyridineacrylic acid 1126-74-5
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10
Release date
2024-07-14
Career Henan Chemical Co
Product
3-Pyridineacrylic acid 1126-74-5
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-10

1126-74-5, 3-Pyridineacrylic acidRelated Search:

Acrylic acid Poly(acrylic acid) 3-Aminopyridine Methacrylic acid 2-Chloro-3-cyanopyridine Methyl acrylate Methyl methacrylate 6-Benzylaminopurine Folic acid Ethyl 2-(Chlorosulfonyl)acetate Citric acid Ascoric Acid ETHOXYLATED BISPHENOL A DIACRYLATE 3-(2-Amino-5-bromo-3-pyridyl)acrylic acid 3-(4-AMINO-3-PYRIDYL)ACRYLIC ACID 3-(2-PYRIDYL)ACRYLIC ACID,2-Pyridineacrylic acid,3-(2-PYRIDYL)ACRYLIC ACID 98% Urocanic acid 3-(5-BROMO-2-METHOXY-3-PYRIDYL)ACRYLIC ACID

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  • 3-(3-Pyridyl)acrylic acid,99%
  • RARECHEM BK HC S246
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  • TRANS-3-(3-PYRIDYL)ACRYLIC ACID
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  • B-(3-PYRIDYL)ACRYLIC ACID
  • 3-PYRIDINEACRYLIC ACID
  • 3-PYRIDYLACRYLIC ACID
  • 3-PYRIDIN-3-YL-ACRYLIC ACID
  • AKOS AUF2066
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  • 3-Pyridineacrylicaci
  • 3-Pyridylpropionic acid
  • 1126-74-5
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