3-Pyridineacrylic acid
- Product Name
- 3-Pyridineacrylic acid
- CAS No.
- 1126-74-5
- Chemical Name
- 3-Pyridineacrylic acid
- Synonyms
- 3-(3-PYRIDYL)ACRYLIC ACID;Pyridine-3-acrylic acid;AKOS AUF2066;RARECHEM BK HC S246;3-Pyridineacrylicaci;3-PYRIDYLACRYLIC ACID;3-PYRIDINEACRYLIC ACID;3-Pyridylpropionic acid;3-PYRIDINYL-ACRYLIC ACID;B-(3-PYRIDYL)ACRYLIC ACID
- CBNumber
- CB9699461
- Molecular Formula
- C8H7NO2
- Formula Weight
- 149.15
- MOL File
- 1126-74-5.mol
3-Pyridineacrylic acid Property
- Melting point:
- 232-235 °C (dec.)(lit.)
- Boiling point:
- 270.21°C (rough estimate)
- Density
- 1.2517 (rough estimate)
- refractive index
- 1.5320 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 3.13±0.10(Predicted)
- form
- Solid
- color
- White
- InChI
- InChI=1S/C8H7NO2/c10-8(11)4-3-7-2-1-5-9-6-7/h1-6H,(H,10,11)
- InChIKey
- VUVORVXMOLQFMO-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C=CC1=CC=CN=C1
- CAS DataBase Reference
- 1126-74-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37/39-36/37/39
- WGK Germany
- 3
- F
- 10
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P1157
- Product name
- 3-(3-Pyridyl)acrylic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- P1157
- Product name
- 3-(3-Pyridyl)acrylic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- P991285
- Product name
- 3-PyridineacrylicAcid
- Packaging
- 2.5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 038635
- Product name
- (2E)-3-Pyridin-3-ylacrylic acid
- Packaging
- 5g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- CS-0031477
- Product name
- 3-(3-Pyridinyl)acrylicacid
- Packaging
- 25g
- Price
- $76
- Updated
- 2021/12/16
3-Pyridineacrylic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Pyridineacrylic Acid is an inhibitor of peptidylglycine amidating monooxygenase.
Synthesis
100390-47-4
19337-97-4
To a solution of butyl 3-(pyridin-3-yl)prop-2-enoate (70 g, 341 mmol, 1.00 equiv) in ethanol (150 mL) was added a solution of potassium hydroxide (40 g, 712.94 mmol, 2.09 equiv) in water (150 mL). The reaction mixture was stirred at room temperature for 20 hours. Upon completion of the reaction, the pH of the solution was adjusted to 6 with 12 M hydrochloric acid.The precipitate was collected by filtration to give 50 g (98% yield) of trans-3-(3-pyridyl)acrylic acid as an off-white solid.LCMS analysis (Method C, electrospray ionization, m/z): retention time = 0.78 min, m/z = 149.9 [M+H]+.
References
[1] Patent: WO2014/74715, 2014, A1. Location in patent: Paragraph 0170
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 770 - 792
3-Pyridineacrylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Pyridineacrylic acid Suppliers
- Tel
- --
- Fax
- --
- enamine@enamine.net
- Country
- Ukraine
- ProdList
- 6216
- Advantage
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View Lastest Price from 3-Pyridineacrylic acid manufacturers
- Product
- 3-Pyridineacrylic acid 1126-74-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-06-11
- Product
- 3-Pyridineacrylic acid 1126-74-5
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10
- Release date
- 2024-07-14
- Product
- 3-Pyridineacrylic acid 1126-74-5
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-10