(+/-)4-HDOHE

Product Name: (+/-)4-HDOHE
CAS No.: 90906-40-4
Chemical Name: (+/-)4-HDOHE
Synonyms: (±)4-HDHA;(±)4-HDHA;(±)4-HDoHE;(+/-)4-HDOHE;IFRKCNPQVIJFAQ-PQVBWYSWSA-N;4-HYDROXY DOCOSAHEXAENOIC ACID;4-Hydroxy-5(E),7(Z),10(Z),13(Z),16(Z),19(Z)-DHA;(+/-)4-HYDROXY-5E,7Z,10Z,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID;5,7,10,13,16,19-Docosahexaenoic acid, 4-hydroxy-, (5E,7Z,10Z,13Z,16Z,19Z)-
CBNumber: CB9700248
Molecular Formula: C22H32O3
Formula Weight: 344.49
MOL File: 90906-40-4.mol

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(+/-)4-HDOHE Property

Boiling point:: 502.3±50.0 °C(Predicted)
Density: 0.995±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka: 4.57±0.10(Predicted)
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 33200
Product name: (±)4-HDHA
Purity: ≥95%
Packaging: 25μg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 33200
Product name: (±)4-HDHA
Purity: ≥95%
Packaging: 50μg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 33200
Product name: (±)4-HDHA
Purity: ≥95%
Packaging: 100μg
Price: $273
Updated: 2024/03/01

Cayman Chemical

Product number: 33200
Product name: (±)4-HDHA
Purity: ≥95%
Packaging: 250μg
Price: $536
Updated: 2023/01/06

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(+/-)4-HDOHE Chemical Properties,Usage,Production

Description

(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 4-HDHA. However, the enzymatic product is most likely the S-isomer. (±)4-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

Uses

(±)4-HDHA (4-Hydroxy docosahexaenoic acid) is an autoxidation product of Docosahexaenoic acid (HY-B2167) (DHA). (±)4-HDHA is a PPARγ agonist, antidiabetic and anti-inflammatory agent[1][2].

IC 50

PPARγ

References

[1] Yamamoto K, et al. 4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis. Biochem Biophys Res Commun. 2008 Mar 14;367(3):566-72. DOI:10.1016/j.bbrc.2007.12.188
[2] Richard Louis Dunbar, et al. Lymph-releasing compositions of fatty acids and uses thereof for lymphatic incorporation and systemic disease treatment. Patent. WO2023146984.

(+/-)4-HDOHE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)4-HDOHE Suppliers

CHINA 22 United States 3 Global 25

Yichang Zhongyitai Trading Co., Ltd.

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Nantong QuanYi Biotechnology Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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90906-40-4, (+/-)4-HDOHERelated Search:

Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) N-BUTYLISOCYANIDE Tosylmethyl isocyanide TERT-BUTYL ISOCYANIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE COBALT(II) ACETYLACETONATE PHENYLSELENOL Cupric acetylacetonate Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) METHYL ISOCYANOACETATE Ethyl isocyanoacetate Benzyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Aluminum acetylacetonate

4-HYDROXY DOCOSAHEXAENOIC ACID

(+/-)4-HDOHE

(+/-)4-HYDROXY-5E,7Z,10Z,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID

(±)4-HDHA

IFRKCNPQVIJFAQ-PQVBWYSWSA-N

5,7,10,13,16,19-Docosahexaenoic acid, 4-hydroxy-, (5E,7Z,10Z,13Z,16Z,19Z)-

(±)4-HDHA

4-Hydroxy-5(E),7(Z),10(Z),13(Z),16(Z),19(Z)-DHA

(±)4-HDoHE

90906-40-4