ChemicalBook > CAS DataBase List > Dexamethasone-17-acetate

Dexamethasone-17-acetate

Product Name
Dexamethasone-17-acetate
CAS No.
1177-87-3
Chemical Name
Dexamethasone-17-acetate
Synonyms
DEXAMETHASONE ACETATE;DEXAMETHASON ACETATE;DEXAMETHASONE 21-ACETATE;9-fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate;Dectan;Panasone;Dectancyl;NSC 39471;Decadronal;Decadron-la
CBNumber
CB9703269
Molecular Formula
C24H31FO6
Formula Weight
434.5
MOL File
1177-87-3.mol
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Dexamethasone-17-acetate Property

Melting point:
238-240 °C(lit.)
alpha 
D25 +73° (chloroform) (Arth, 1958); D +77.6° (Oliveto)
Boiling point:
579.4±50.0 °C(Predicted)
Density 
1.1517 (estimate)
refractive index 
87 ° (C=1, Dioxane)
storage temp. 
2-8°C
solubility 
Soluble at 100 mg/ml in acetone
pka
12.08±0.70(Predicted)
form 
Powder
color 
White
biological source
synthetic
Water Solubility 
13mg/L(25 ºC)
Merck 
2943
BRN 
2342608
CAS DataBase Reference
1177-87-3(CAS DataBase Reference)
NIST Chemistry Reference
Prednisolone, 9alpha-fluoro-16alpha-methyl-, acetate(1177-87-3)
EPA Substance Registry System
Dexamethasone-21-acetate (1177-87-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
WGK Germany 
3
RTECS 
TU4050000
TSCA 
Yes
HS Code 
29372290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1176506
Product name
Dexamethasone acetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
46166
Product name
Dexamethasone 21-acetate
Purity
VETRANAL
Packaging
100mg
Price
$81.7
Updated
2022/05/15
Alfa Aesar
Product number
J63691
Product name
Dexamethasone acetate
Packaging
1g
Price
$186
Updated
2024/03/01
Alfa Aesar
Product number
J63691
Product name
Dexamethasone acetate
Packaging
5g
Price
$666
Updated
2024/03/01
Cayman Chemical
Product number
22286
Product name
Dexamethasone Acetate
Purity
≥98%
Packaging
100mg
Price
$33
Updated
2024/03/01
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Dexamethasone-17-acetate Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Dexacen,Central,US,1977

Uses

Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.

Uses

Dexamethasone has many uses in the treatment of cancer. Dexamethasone relieves inflammation in various parts of the body. To treat or prevent allergic reactions. As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions. As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma. It is also used for replacement therapy in adrenal insufficiency and in a screening test for the diagnosis of cushing's syndrome. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.

Uses

Dexamethasone acetate is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations using chromatography ttechniques.

Definition

ChEBI: Dexamethasone acetate is a corticosteroid hormone.

Manufacturing Process

The preparation of dexamethasone acetate is described in US Patent 3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous hydrofluoric acid are admixed and treated with 480 mg of 9β,11β-epoxy-17αhydroxy-21-acetoxy-16α-methyl-?1,4-pregnadiene-3,20-dione (prepared according to E.P. Oliveto et al, J. Am. Chem. Soc., 80, 44331, 1958). The steroid dissolves in about 15 minutes. The reaction mixture is shaken for two hours at a temperature between 0 and +5°C, and then poured into 75 cc of
water containing in suspension, 7.5 grams of sodium bicarbonate. The mixture is vacuum filtered, the filter cake washed and then dried at 100°C, yielding 460 mg of crude hexadecadrol contaminated with a small amount of the starting material. A single recrystallization from methylene chloride yields 370 mg of the pure product having a melting point of 170°C and 229°C. The mother liquor yields 62 mg of the starting material, and a remainder constituting a mixture of starting and final materials with little other contamination.

brand name

Decadron (Merck).

Therapeutic Function

9-Fluoro-11β,17-dihydroxy-21-acetoxy-16α-methylpregna1,4-diene-3,20-dione

Safety Profile

Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F-.

Purification Methods

Dexamethasone 21-acetate is purified on neutral Al2O3 using CHCl3 as eluent, the fractions are evaporated, and the residue is recrystallised from CHCl3. It has max at 239nm. [Oliveto et al. J Am Chem Soc 8 0 4431 1958]. [Beilstein 8 IV 3501.]

Dexamethasone-17-acetate Preparation Products And Raw materials

Raw materials

Progesterone Ethylene glycol Hydrogen fluoride Methyl bromide

Preparation Products

9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-phosphate piperazine salt
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View Lastest Price from Dexamethasone-17-acetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dexamethasone-17-acetate 1177-87-3
Price
US $0.00/g
Min. Order
100g
Purity
99.0%
Supply Ability
50kg/month
Release date
2021-07-27
Baoji Guokang Bio-Technology Co., Ltd.
Product
Dexamethasone-17-acetate 1177-87-3
Price
US $1200.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2021-06-03
Wuhan Haorong Biotechnology Co.,Ltd
Product
Dexamethasone-17-acetate 1177-87-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-07-27

1177-87-3, Dexamethasone-17-acetateRelated Search:

Dexamethasone-d5 Dexamethasone 21-phosphate disodium salt 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate Dexamethasone palmitate DexaMethasone β-D-Glucuronide SodiuM Salt Desoximetasone DEXAMETHASONE SODIUM PHOSPHATE Dexamethasone EP Impurity E Dexamethasone Impurity I 1,2-Dihydro DesoxyMetasone Dexamethasone 9,11-epoxide Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(3-sulfobenzoyl)oxy]-, monosodium salt, (11beta,16alpha)- Dexamethasone 21-Propionate PSXDNQUHAFMVPT-NWQAGDSVSA-N Dexamethasone-17,20 21-Aldehyde dexamethasone 21-(3-phenylpropionate) Dexamethasone 17-propionate 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate

  • 20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-pregna-4-diene-3
  • 9alpha-Fluoro-16alpha-methylprednisolone acetate
  • 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-acetate
  • 9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate
  • 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
  • 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-acetate
  • 9-Fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione acetate
  • Dalalone D.P.
  • Dalalone L.A.
  • Decadronal
  • Decadron-L.A.
  • Decadron-la
  • Dectan
  • Dectancyl
  • Dexacortisyl
  • Dex-Cortidelt acetate
  • Fortecortin
  • Fortecortin (crystal suspension)
  • 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate
  • Dexamethasone Acetate, Anhydrous, Micronized
  • 21-Acetoxy-9α-fluoro-11β,17α-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
  • 9-Fluoro-3,20-dioxo-16α-methylpregna-1,4-diene-11β,17,21-triol 21-acetate
  • Dexametasone acetate
  • MPB Dexamethasone-21-acetate
  • 21-O-Acetyl Dexamethasone
  • 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate
  • Dexamethasone 21-acetate,9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate
  • Dexamethasone Acetate (200 mg)
  • Dexamethasone Acetate (200 mg)H0E3390.996mg/mg(dr)
  • Dexamethasone-17-ace
  • 9-ALPHA -FLUORO-11BETA 17ALPHA 21-TRIHYDROXY-16ALPHA -METHYL-1 4-PREGNADIENE-3 20-DIONE
  • 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-triMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • Dexamethasone 21-Acetate Solution, 100ppm
  • Dexamethasone Acetate Dexamethasoneacetate dexamethasone-21-acetate
  • DEXAMETHASON ACETATE
  • dexamethasone-17-acetate
  • DEXAMETHASONE 21-ACETATE
  • DEXAMETHASONE ACETATE
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE
  • PREDNISOLONE F ACETATE
  • 9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE-21-ACETATE
  • 9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA,17-ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE ACETATE
  • 9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE-21-ACETATE
  • 9 ALPHA-FLUORO-11 BETA,17 ALPHA,21-TRIHYDRO-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-ACETATE
  • 9a-fluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate
  • Panasone
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, 21-acetate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, acetate
  • DEXAMETHASON 21-ACETATE VETRANAL, 250 MG
  • DEXAMETHASONE ACETATE EPD(CRM STANDARD)
  • DEXAMETHASONE ACETATE USP(CRM STANDARD)
  • DEXAMETHASONE ACETATE WHO(CRM STANDARD)
  • DEXAMETHASONE 21-ACETATE, USP
  • 9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate
  • DEXAMETHASONEACETATE,ANHYDROUS,MICRONIZED,USP
  • 16α-Methyl-9α-fluoroprednisolone 21-acetate
  • NSC 39471