Methyl 3-hydroxypropanoate Property

Melting point:

147-148 °C(Solv: benzene (71-43-2); cyclohexane (110-82-7))

Boiling point:

179°C (estimate)

Density 

1.1050

refractive index 

1.4300

storage temp. 

2-8°C

solubility 

Chloroform, Methanol

form 

Oil

pka

13.89±0.10(Predicted)

color 

Colourless

InChI

InChI=1S/C4H8O3/c1-7-4(6)2-3-5/h5H,2-3H2,1H3

InChIKey

RVGLEPQPVDUSOJ-UHFFFAOYSA-N

SMILES

C(OC)(=O)CCO

Safety

HazardClass 

IRRITANT

HS Code 

2918199890

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

Methyl 3-hydroxypropanoate Chemical Properties,Usage,Production

Definition

ChEBI: 2-Methyl-3-hydroxypropanoate is a 3-hydroxy carboxylic acid.

General Description

Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.