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Vardenafil dihydrochloride

Product Name
Vardenafil dihydrochloride
CAS No.
224789-15-5
Chemical Name
Vardenafil dihydrochloride
Synonyms
Levitra;VARDANAFIL;Vardenafil 2HCl;Vardenafil DiHCl;VARDENAFIL CITRATE;Vardenafil Sexual Powder;Vardenafil dihydrochloride;Vardenafil dihydrochloride solution;VARDENAFILDIHYDROCHLORIDE(SUBJECTTOPATENTFREE);Vardenafil dihydrochloride 100 μg/mL in Acetonitrile
CBNumber
CB9712210
Molecular Formula
C23H33ClN6O4S
Formula Weight
525.07
MOL File
224789-15-5.mol
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Vardenafil dihydrochloride Property

Melting point:
214-216°C
storage temp. 
Refrigerator
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChIKey
NOIHTGOGFDFCBN-UHFFFAOYSA-N
SMILES
C1N(S(=O)(=O)C2C=C(C3NC(=O)C4=C(C)N=C(CCC)N4N=3)C(OCC)=CC=2)CCN(CC)C1.Cl.Cl
CAS DataBase Reference
224789-15-5(CAS DataBase Reference)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
V098001
Product name
VardenafilDihydrochlorideSalt
Packaging
50mg
Price
$400
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0019443
Product name
VARDENAFIL DIHYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$500.59
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
67460
Product name
VardenafilDiHClSalt
Packaging
10mg
Price
$610
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
67460
Product name
VardenafilDiHClSalt
Packaging
50mg
Price
$825
Updated
2021/12/16
Axon Medchem
Product number
Axon3396
Product name
Vardenafildihydrochloride-BAY38–9456
Purity
99%
Packaging
10mg
Price
$66
Updated
2021/12/16
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Vardenafil dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Cyrstalline Solid

Uses

erectile dysfunction, PD5 inhibitor

Uses

Vardenafil Dihydrochloride Salt is a selective phosphodiesterase type 5 (PDE5) inhibitor.

Uses

A selective phsphodiesterase type 5 (PDE5) inhibitor.

in vivo

Vardenafil dihydrochloride (0.03 mg/kg; i.v.) exhibits facilitator effects in rats with cavernous nerve injury[4].
Vardenafil dihydrochloride (0.17 mg/kg; i.v.; once daily; 7 d) protects liver against Con A–induced hepatitis, and decreases the expression of NF-??B and iNOS in hepatic tissue[5].
Vardenafil dihydrochloride (10 mg/kg; p.o.; once daily; 25 weeks) prevents the reduction of tissue cGMP levels and the increase in 3-NT generation in ZDF hearts[6].

Animal Model:Male rat (9-week-old) underwent surgery for laparotomy or bilateral cavernous nerve (CN) crush injury[4]
Dosage:0.03 mg/kg
Administration:Intravenous injection
Result:Restored normal erectile responses with a combind administration of BAY 60-4552 (0.03, 0.3 mg/kg).
Animal Model:Liver injury induced by Con A in male Swiss albino mice (20 ± 2 g)[5]
Dosage:0.17 mg/kg
Administration:Intravenous injection; once daily, for 7 days; as a pretreatment
Result:Reduced the levels of serum transaminases and alleviated Con A-induced hepatitis.
Animal Model:Male 7-week-old Zucker diabetic fatty (ZDF) rats (preserved ejection fraction, HFpEF)[6]
Dosage:10 mg/kg
Administration:Oral gavage; once daily, for 25 weeks
Result:Improved myofilament function in diabetic rat hearts.

IC 50

PDE5: 0.7 nM (IC50); PDE1: 180 nM (IC50); PDE6: 11 nM (IC50)

Vardenafil dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Vardenafil dihydrochloride Suppliers

Canada 1 China 73 Germany 1 India 4 United Kingdom 4 United States 13 Global 96
Henan Wasai Biological Technology Co. LTD
Tel
13526611694
Email
2582571190@qq.com
Country
China
ProdList
69
Advantage
58
Hubei Awin Bio-Chemical Co., Ltd
Tel
17362549610
Email
312523773@qq.com
Country
China
ProdList
115
Advantage
58
Henan Kuanzhan Biological Technology Co. LTD
Tel
13939439944; 15660520685
Email
w986122@qq.com
Country
China
ProdList
19
Advantage
58
Shandong Baixinchangda Biotechnology Co., Ltd
Tel
19229895729 19229895729
Country
China
ProdList
33
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6468
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
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View Lastest Price from Vardenafil dihydrochloride manufacturers

Forest chemical technology
Product
Vardenafil dihydrochloride 224789-15-5
Price
US $0.00-0.00/G
Min. Order
1G
Purity
99%
Supply Ability
1 ton/year
Release date
2025-01-09
Hebei Ganmiao New material Technology Co., LTD
Product
Vardenafil dihydrochloride 224789-15-5
Price
US $10.00-8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-06
Wuhan Xinhao Biotechnology Co., Ltd
Product
Vardenafil dihydrochloride 224789-15-5
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-03-08

224789-15-5, Vardenafil dihydrochlorideRelated Search:

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  • VARDENAFIL CITRATE
  • VARDANAFIL
  • VARDENAFILDIHYDROCHLORIDE(SUBJECTTOPATENTFREE)
  • 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine dihydrochloride
  • Levitra
  • Vardenafil dihydrochloride
  • 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one dihydrochloride
  • 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one dihydrochloride
  • 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one
  • Vardenafil dihydrochloride solution
  • Vardenafil DiHCl
  • Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, dihydrochloride
  • Vardenafil Sexual Powder
  • Vardenafil 2HCl
  • Vardenafil dihydrochloride 100 μg/mL in Acetonitrile
  • Vardenafil Dihydrochloride 1.0 mg/ml in Methanol (as free base)
  • 224789-15-5
  • C23H32N6O4S2HClC23H34Cl2N6O4S
  • C23H32N6O4S2HCl
  • 11
  • Active Pharmaceutical Ingredients
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • LEVITRA
  • 224789-15-5