4-Amino-3-methylbenzoic acid
- Product Name
- 4-Amino-3-methylbenzoic acid
- CAS No.
- 2486-70-6
- Chemical Name
- 4-Amino-3-methylbenzoic acid
- Synonyms
- 3-METHYL-4-AMINOBENZOIC ACID;Fluralaner-034;RARECHEM AL BO 2396;4-Amino-3-methylbenz;4-AMINO-M-TOLUIC ACID;4-Amino-n-toluic acid;3-Methyl-4-AMino acid;Carbidopa Impurity 24;Fluralaner Impurity 54;4-Amino-3-methylbenzoic
- CBNumber
- CB9724176
- Molecular Formula
- C8H9NO2
- Formula Weight
- 151.16
- MOL File
- 2486-70-6.mol
4-Amino-3-methylbenzoic acid Property
- Melting point:
- 169-171 °C (lit.)
- Boiling point:
- 273.17°C (rough estimate)
- Density
- 1.2023 (rough estimate)
- refractive index
- 1.5810 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.93±0.10(Predicted)
- color
- Pale Brown to Light Brown
- BRN
- 2802615
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C8H9NO2/c1-5-4-6(8(10)11)2-3-7(5)9/h2-4H,9H2,1H3,(H,10,11)
- InChIKey
- NHFKECPTBZZFBC-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(N)C(C)=C1
- CAS DataBase Reference
- 2486-70-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Amino-3-methylbenzoic acid(2486-70-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A63007
- Product name
- 4-Amino-3-methylbenzoic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $46.6
- Updated
- 2023/01/07
- Product number
- A63007
- Product name
- 4-Amino-3-methylbenzoic acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $426
- Updated
- 2023/01/07
- Product number
- A1353
- Product name
- 4-Amino-3-methylbenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- A1353
- Product name
- 4-Amino-3-methylbenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $167
- Updated
- 2025/07/31
- Product number
- A614585
- Product name
- 4-Amino-3-methylbenzoic Acid
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
4-Amino-3-methylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
beige or light buff to orange
Uses
4-Amino-3-methylbenzoic Acid is used in preparation of Amide-substituted Benzo[d]imidazole compounds as selective inhibitors of indoleamine-2,3-dioxygenases.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
3113-71-1
2486-70-6
At room temperature and under hydrogen atmosphere, 3-methyl-4-nitrobenzoic acid (100 g, 552.04 mmol) was dissolved in methanol (2000 mL) followed by addition of palladium carbon catalyst (5.0 g). The reaction mixture was stirred continuously at room temperature for 24 hours. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to give the light yellow solid product 4-amino-3-methylbenzoic acid (80 g, 96% yield).
References
[1] Advanced Synthesis and Catalysis, 2010, vol. 352, # 9, p. 1451 - 1454
[2] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[3] Journal of Organic Chemistry, 2008, vol. 73, # 21, p. 8631 - 8634
[4] Patent: CN106831460, 2017, A. Location in patent: Paragraph 0029-0059
[5] Patent: CN107501106, 2017, A. Location in patent: Paragraph 0025-0047
4-Amino-3-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-3-methylbenzoic acid manufacturers
- Product
- 4-Amino-3-methylbenzoic acid 2486-70-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-12
- Product
- 4-Amino-3-methylbenzoic acid 2486-70-6
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-12-02
- Product
- 4-Amino-3-methylbenzoic acid 2486-70-6
- Price
- US $78.26/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 98.50%HPLC
- Supply Ability
- 20tons/month
- Release date
- 2021-09-24