ChemicalBook > CAS DataBase List > MY-5445

MY-5445

Product Name: MY-5445
CAS No.: 78351-75-4
Chemical Name: MY-5445
Synonyms: MY-5445;MY 5445;MY5445;MY-5445, 10 mM in DMSO;1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE;1-(3-Chloroanilino)-4-phenylphthalazine >1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE;N-(3-chlorophenyl)-4-phenylphthalazin-1-amine;N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine;1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-;aggregation,platelet,Inhibitor,anticancer,inhibit,MY5445,neuropathic,MY 5445,Phosphodiesterase (PDE),neuropathic pain,allodynia,MY-5445
CBNumber: CB9739543
Molecular Formula: C20H14ClN3
Formula Weight: 331.8
MOL File: 78351-75-4.mol

Less

MY-5445 Property

Boiling point:: 539.7±50.0 °C(Predicted)
Density: 1.310±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
pka: 4.91±0.30(Predicted)
form: Yellow solid.
color: White to Light yellow

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 2933.99.8290

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: C2884
Product name: 1-(3-Chloroanilino)-4-phenylphthalazine
Purity: >98.0%(GC)
Packaging: 20mg
Price: $94
Updated: 2025/07/31

TCI Chemical

Product number: C2884
Product name: 1-(3-Chloroanilino)-4-phenylphthalazine
Purity: >98.0%(GC)
Packaging: 100mg
Price: $322
Updated: 2025/07/31

Cayman Chemical

Product number: 20872
Product name: MY-5445
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20872
Product name: MY-5445
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 20872
Product name: MY-5445
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Less

MY-5445 Chemical Properties,Usage,Production

Description

MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a K_i value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with K_i values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC₅₀ value of 4 μM.

Uses

MY-5445 is a selective cGMP phosphodiesterase inhibitor. Potent PDE5 inhibitor.

Definition

ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines.

Biological Activity

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M).

in vivo

MY-5445 (0.5-3 mg/kg; i.p.; twice a day; for 15 days) produces a significant relief of mechanical hypersensitivity^[3].

Animal Model:	C57BL/6J male mice^[3]
Dosage:	0.5 mg/kg, 3 mg/kg
Administration:	Intraperitoneal injection, twice a day, for 15 days
Result:	Alleviated the cuff-induced allodynia.

IC 50

PDE5: 1.3 μM (Ki); PDE5: 6.7 μM (IC₅₀); PDE4: 37 μM (IC₅₀)

References

[1] JOHN E. SOUNESS. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine[J]. British Journal of Pharmacology, 1989, 98 3: 725-734. DOI: 10.1111/j.1476-5381.1989.tb14599.x
[2] T YAMAMOTO. Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.[J]. The Journal of Biological Chemistry, 1983, 258 23: 14173-14177.

MY-5445 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

MY-5445 Suppliers

Americas 1 China 73 Europe 1 Germany 2 India 1 Italy 1 Japan 3 Switzerland 2 United Kingdom 3 United States 19 Global 106

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: zwchem@163.com
Country: China
ProdList: 616
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4941
Advantage: 55

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9898
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Hangzhou Bingochem Co., Ltd.

Tel: 0571-8512-5372
Email: sales@bingochem.com
Country: China
ProdList: 21669
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59101766 13125137661
Email: 2853877621@qq.com
Country: China
ProdList: 7975
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 24727
Advantage: 58

Shenzhen Science Biology Co., Ltd.

Tel: 18617181553
Country: CHINA
ProdList: 112
Advantage: 58

Guangzhou Biopark Technology Co., Ltd.

Tel: 020-83808789
Country: CHINA
ProdList: 179
Advantage: 58

Jinan Lemon Biotechnology Co., Ltd.

Tel: 138000000
Email: geans@163.com
Country: China
ProdList: 155
Advantage: 58

Guangzhou Jingyan Biotechnology Co., Ltd.

Tel: 13822277471
Country: CHINA
ProdList: 187
Advantage: 58

Guangzhou Weisheng Biotechnology Co., Ltd.

Tel: 17765667235
Country: CHINA
ProdList: 129
Advantage: 58

Guangzhou Zhuanyan Biotechnology Co., Ltd.

Tel: 18926165828
Country: CHINA
ProdList: 198
Advantage: 58

Guangzhou Ruifeng Biotechnology Co., Ltd.

Tel: 14715141318
Country: CHINA
ProdList: 181
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

78351-75-4, MY-5445Related Search:

ZARDAVERINE RO 20-1724 BRL 50481 Vinpocetine ZAPRINAST ROLIPRAM Cilostazol (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE CILOSTAMIDE EHNA HYDROCHLORIDE 3-AMINO-6-METHYLPYRIDAZINE AKOS BB-5445 3-AMINO-6-PHENYLPYRIDAZINE MY-5445 1-AMINOPHTHALAZINE RARECHEM AK PP 5445 AURORA KA-5445 AURORA 5445

MY-5445

1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE

1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE

N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine

N-(3-chlorophenyl)-4-phenylphthalazin-1-amine

MY 5445;MY5445

1-(3-Chloroanilino)-4-phenylphthalazine &gt

aggregation,platelet,Inhibitor,anticancer,inhibit,MY5445,neuropathic,MY 5445,Phosphodiesterase (PDE),neuropathic pain,allodynia,MY-5445

1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-

MY-5445, 10 mM in DMSO

78351-75-4

C20H14ClN3

Cyclic Nucleotide related