MY-5445
- Product Name
- MY-5445
- CAS No.
- 78351-75-4
- Chemical Name
- MY-5445
- Synonyms
- MY-5445;MY 5445;MY5445;1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE;1-(3-Chloroanilino)-4-phenylphthalazine >1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE;N-(3-chlorophenyl)-4-phenylphthalazin-1-amine;N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine;1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-;aggregation,platelet,Inhibitor,anticancer,inhibit,MY5445,neuropathic,MY 5445,Phosphodiesterase (PDE),neuropathic pain,allodynia,MY-5445
- CBNumber
- CB9739543
- Molecular Formula
- C20H14ClN3
- Formula Weight
- 331.8
- MOL File
- 78351-75-4.mol
MY-5445 Property
- Boiling point:
- 539.7±50.0 °C(Predicted)
- Density
- 1.310±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
- pka
- 4.91±0.30(Predicted)
- form
- Yellow solid.
- color
- White to Light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C2884
- Product name
- 1-(3-Chloroanilino)-4-phenylphthalazine
- Purity
- >98.0%(GC)
- Packaging
- 20mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- C2884
- Product name
- 1-(3-Chloroanilino)-4-phenylphthalazine
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $358
- Updated
- 2024/03/01
- Product number
- 20872
- Product name
- MY-5445
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20872
- Product name
- MY-5445
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 20872
- Product name
- MY-5445
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
MY-5445 Chemical Properties,Usage,Production
Description
MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 μM.
Uses
MY-5445 is a selective cGMP phosphodiesterase inhibitor. Potent PDE5 inhibitor.
Definition
ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines.
Biological Activity
Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M).