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Esomeprazole magnesium trihydrate

Product Name
Esomeprazole magnesium trihydrate
CAS No.
217087-09-7
Chemical Name
Esomeprazole magnesium trihydrate
Synonyms
Nexium;EsomepazoleTrihydrate;Esomeprazole Mg Trihydrate;ESOPMEPRAZOLE MG TRIHYDRATE;EsoMeprazole Meg. Trihydrate;Omeprazole 8.5%/12.5% pellels;Esomeprazole Magnesium (10 mg);Esomeprazole Magnesium (25 mg);Omeprazole Magnesium Trihydrate;EsoMeprazole Magnesiu Trihydrate
CBNumber
CB9740619
Molecular Formula
C34H38MgN6O7S2
Formula Weight
731.14
MOL File
217087-09-7.mol
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Esomeprazole magnesium trihydrate Property

Melting point:
184-189°C (dec.)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Slightly soluble in water, soluble in methanol, practically insoluble in heptane.
form 
Solid
color 
White to off-white
InChI
InChI=1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;
InChIKey
VEVZQDGATGBLIC-UHFFFAOYSA-N
SMILES
C(C1N=CC(C)=C(OC)C=1C)S1C2[N-]C3=CC(OC)=CC=C3N=2[Mg+2]2(O=S(CC3N=CC(C)=C(OC)C=3C)C3[N-]C4=CC(OC)=CC=C4N2=3)O=1.O
CAS DataBase Reference
217087-09-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001028
Product name
Esomeprazole magnesium trihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
5 mg
Price
$157
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR1585
Product name
Esomeprazole Magnesium
Packaging
1g
Price
$208
Updated
2025/07/31
Sigma-Aldrich
Product number
1249789
Product name
Esomeprazole magnesium
Purity
UnitedStatesPharmacopeia(USP)ReferenceStandard
Packaging
100MG
Price
$470
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0001028
Product name
Esomeprazole magnesium trihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001028
Price
$154
Updated
2024/03/01
ChemScene
Product number
CS-1024
Product name
Esomeprazole magnesium trihydrate
Packaging
50mg
Price
$156
Updated
2021/12/16
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Esomeprazole magnesium trihydrate Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

S-Form of Omeprazole. Gastric proton-pump inhibitor

Uses

Esomeprazole Magnesium Trihydrate is used in preparation of esomeprazole magnesium trihydrate.

Uses

esomeprazole magnesium trihydrate for the healing of peptic ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.

  1. Zollinger-Ellison syndrome
  2. Peptic ulcer, site unspecified
  3. Duodenal ulcer
  4. Gastric ulcer
  5. Gastro-oesophageal reflux disease
Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). Esomeprazole is registered by the Therapeutic Goods Administration (TGA) for the following indications:
  1. Gastro-Oesophageal Reflux Disease (GORD):
  2. treatment of erosive reflux oesophagitis;
  3. long-term management of patients with healed oesophagitis to prevent relapse;
  4. symptomatic treatment of gastro-oesophageal reflux disease (GORD).
In combination with appropriate antibiotics for:
  1. healing of duodenal ulcer associated with Helicobacter pylori;
  2. eradication of Helicobacter pylori in patients with active or healed peptic ulcer.
  3. Short-term treatment of upper gastrointestinal symptoms associated with non-steroidal anti-inflammatory drug (NSAID) (non-selective and COX-2 selective) therapy.
  4. Healing of gastric ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
  5. Prevention of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy in patients at risk.

brand name

Nexium (AstraZeneca).

Biological Activity

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent, orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release by inhibiting V-H+-ATPases.

in vivo

Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity[1].

Animal Model:A/J mice[1]
Dosage:0.5 mg/kg, 5 mg/kg, 50 mg/kg
Administration:Oral gavage; daily; for 10 days
Result:Gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased.

Esomeprazole magnesium trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Esomeprazole magnesium trihydrate Suppliers

Canada 1 China 346 France 2 Germany 3 India 69 Italy 1 South Korea 1 United Kingdom 5 United States 26 Global 454
Wuhan kemike Biomedical Technology Co., Ltd
Tel
027-87747081 18186681184
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1344475572@qq.com
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China
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7221
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Yulin Runtianchang Chemical Co., Ltd
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15890142075
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3555133855@qq.com
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China
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9850
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Zhemical Co., Ltd.
Tel
760-89935616
Fax
0760-86925770
Email
zc@zhemical.com
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China
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57
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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JinYan Chemicals(ShangHai) Co.,Ltd.
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13817811078
Fax
86-021-50426522,50426273
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sales@jingyan-chemical.com
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China
ProdList
9976
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LGM Pharma
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1-(800)-881-8210
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615-250-9817
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inquiries@lgmpharma.com
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United States
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
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32321
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50
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View Lastest Price from Esomeprazole magnesium trihydrate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Esomeprazole magnesium 217087-09-7
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-24
Wuhan JiyunZen Tech Co., Ltd.
Product
esomeprazole magnesium 217087-09-7
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Esomeprazole magnesium trihydrate 217087-09-7
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%-102%
Supply Ability
500kgs
Release date
2021-07-09

217087-09-7, Esomeprazole magnesium trihydrateRelated Search:

Magnesium sulfate heptahydrate Dimethyl sulfoxide Magnesium oxide Esomeprazole Magnesium sulfate Esomeprazole magnesium (Trifluoromethoxy)benzene Benzimidazole Dimethyl sulfate Dimethyl ether Anisole Dimethyl carbonate Dimethyl fumarate Dimethyl phthalate ETHANE Esomeprazole sodium Magnesium stearate p-Anisidine Esomeprazole Magnesium Trihydrate Usp Omeprazole Magnesium Trihydrate

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