ChemicalBook > CAS DataBase List > 3-Chloro-4-fluoronitrobenzene

3-Chloro-4-fluoronitrobenzene

Synthesis

Product Name: 3-Chloro-4-fluoronitrobenzene
CAS No.: 350-30-1
Chemical Name: 3-Chloro-4-fluoronitrobenzene
Synonyms: 2-CHLORO-1-FLUORO-4-NITROBENZENE;3-Chloro-4-fluoronit;Gefitinib Impurity 92;3-chloro-4-fluorobenzene;3-CHLORO-4-FLUORONITROANILINE;4-FLUORO-3-CHLORONITROBENZENE;3-CHLORO-4-FLUORONITROBENZENE;3-chioro-4-fluoronitrobenzene;1-CHLORO-2-FLUORO-5-NITROBENZENE;2-chloro-1-fluoro-4-nitro-benzen
CBNumber: CB9743847
Molecular Formula: C6H3ClFNO2
Formula Weight: 175.54
MOL File: 350-30-1.mol

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3-Chloro-4-fluoronitrobenzene Property

Melting point:: 40-42 °C(lit.)
Boiling point:: 227-232°C
Density: 1.61
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Light yellow to Green
BRN: 1944997
InChI: InChI=1S/C6H3ClFNO2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H
InChIKey: DPHCXXYPSYMICK-UHFFFAOYSA-N
SMILES: C1(F)=CC=C([N+]([O-])=O)C=C1Cl
CAS DataBase Reference: 350-30-1(CAS DataBase Reference)
NIST Chemistry Reference: 3-Chloro-4-fluoronitrobenzene(350-30-1)
EPA Substance Registry System: 3-Chloro-4-fluoronitrobenzene (350-30-1)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38-20/21/22
Safety Statements: 26-39-36/37/39
RIDADR: 2811
WGK Germany: 3
RTECS: CZ0720000
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 233234
Product name: 2-Chloro-1-fluoro-4-nitrobenzene
Purity: 98%
Packaging: 25g
Price: $122.5
Updated: 2025/07/31

TCI Chemical

Product number: C1041
Product name: 3-Chloro-4-fluoronitrobenzene
Purity: >95.0%(GC)
Packaging: 25g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: C1041
Product name: 3-Chloro-4-fluoronitrobenzene
Purity: >95.0%(GC)
Packaging: 250g
Price: $96
Updated: 2025/07/31

TRC

Product number: C368300
Product name: 3-Chloro-4-fluoronitrobenzene
Packaging: 25g
Price: $105
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK447865
Product name: 3-Chloro-4-fluoronitrobenzene
Purity: 98%
Packaging: 25g
Price: $107
Updated: 2021/12/16

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3-Chloro-4-fluoronitrobenzene Chemical Properties,Usage,Production

Synthesis

In certain instances, when both chloro and nitro may act as a leaving group, a surprising selectivity of one over the other is observed, for example chloro-2,5- dinitrobenzene was converted to 4-fluoro-3-chloronitrobenzene.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-1-fluoro-4-nitrobenzene is an intermediate used in synthesis of benzoimidolones on Ameba resin and methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate.

Uses

2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:

benzoimidolones on Ameba resin
methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Synthetic Communications, 21, p. 505, 1991 DOI: 10.1080/00397919108016776

General Description

2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)₆ and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.

References

[1] Catalysis Today, 2012, vol. 198, # 1, p. 300 - 304
[2] Chemical Communications, 1996, # 3, p. 297 - 298
[3] Chemical Communications, 1996, # 3, p. 297 - 298
[4] Journal of Fluorine Chemistry, 2004, vol. 125, # 5, p. 701 - 704
[5] Advanced Synthesis and Catalysis, 2008, vol. 350, # 17, p. 2677 - 2682

3-Chloro-4-fluoronitrobenzene Preparation Products And Raw materials

Raw materials

4-Fluoronitrobenzene Fluorobenzene

Preparation Products

Norfloxacin 1,3-Dichloro-4-fluorobenzene

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3-Chloro-4-fluoronitrobenzene Suppliers

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View Lastest Price from 3-Chloro-4-fluoronitrobenzene manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3-Chloro-4-fluoronitrobenzene 350-30-1
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Baoji Guokang Healthchem co.,ltd

Product: 3-Chloro-4-fluoronitrobenzene 350-30-1
Price: US $79.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 10T
Release date: 2021-06-07

Honest Joy Holdings Limited

Product: 3-Chloro-4-fluoronitrobenzene 350-30-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.4%
Supply Ability: 100 tons
Release date: 2022-02-18

350-30-1, 3-Chloro-4-fluoronitrobenzeneRelated Search:

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3-Chloro-4-fluoronitrobenzene 98%

3-Chloro-4-fluoronitrobenzene98%

1-Nitro-3-chloro-4-fluorobenzene

1-Nitro-4-fluoro-3-chlorobenzene

3-Chloro-4-fluoro-1-nitrobenzene

3-Chloro-4-fluoronit

3-chioro-4-fluoronitrobenzene

3-Chloro-4-fluoronitrobenzene &gt

Gefitinib Impurity 92

3-Chloro-4-fluoronitrobenzene ISO 9001：2015 REACH

Geftinib Impurity : 3-Chloro-4-fluro-nitribenzene

350-30-1

350-31-1

C6H3ClFNO2

ClC6H3FNO2

Nitro Compounds

Organic Building Blocks

Nitrogen Compounds

Building Blocks

Fluorinated benzene series

Nitro Compounds

Nitrogen Compounds

Organic Building Blocks