5-Nitro-1,10-phenanthroline

Product Name: 5-Nitro-1,10-phenanthroline
CAS No.: 4199-88-6
Chemical Name: 5-Nitro-1,10-phenanthroline
Synonyms: 5-NP;5-Nitro-1;NITROFERROIN;TIMTEC-BB SBB008850;5-nitro-10-phenanthroline;5-Nitro-1,10-phenthroline;5-Nitro-1,10-phenathroline;5-NITRO-1,10-PHENANTHROLINE;1,10-Phenanthroline, 5-nitro-;5-Nitro-1,10-phenanthroline>
CBNumber: CB9747931
Molecular Formula: C12H7N3O2
Formula Weight: 225.2
MOL File: 4199-88-6.mol

More

Less

5-Nitro-1,10-phenanthroline Property

Melting point:: 202-204 °C(lit.)
Boiling point:: 366.71°C (rough estimate)
Density: 1.2844 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Alcohol,Benzene
pka: pK1:3.232(+1) (25°C)
form: crystalline
color: yellow to orange
biological source: synthetic
Water Solubility: insoluble
BRN: 196245
InChI: InChI=1S/C12H7N3O2/c16-15(17)10-7-8-3-1-5-13-11(8)12-9(10)4-2-6-14-12/h1-7H
InChIKey: PDDBTWXLNJNICS-UHFFFAOYSA-N
SMILES: N1C2C(=C([N+]([O-])=O)C=C3C=2N=CC=C3)C=CC=1
CAS DataBase Reference: 4199-88-6(CAS DataBase Reference)
EPA Substance Registry System: 1,10-Phenanthroline, 5-nitro- (4199-88-6)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-40
Safety Statements: 26-36-24/25-22
WGK Germany: 3
TSCA: Yes
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N8501
Product name: 5-Nitro-1,10-phenanthroline
Purity: ≥97%, crystalline
Packaging: 1g
Price: $173.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: N8501
Product name: 5-Nitro-1,10-phenanthroline
Purity: ≥97%, crystalline
Packaging: 5g
Price: $620.2
Updated: 2025/07/31

TCI Chemical

Product number: N0214
Product name: 5-Nitro-1,10-phenanthroline
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $77
Updated: 2025/07/31

TRC

Product number: N503463
Product name: 5-Nitro-1,10-phenanthroline
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 093580
Product name: 5-Nitro-1,10-phenanthroline
Purity: 98%
Packaging: 1g
Price: $189
Updated: 2021/12/16

More

Less

5-Nitro-1,10-phenanthroline Chemical Properties,Usage,Production

Chemical Properties

Light yellow to yellow-brown crystalline powder

Uses

5-Nitro-1,10-phenanthroline complexes of iron find wide applications in redox titrations. It is used as a precursor for the synthesis of 5-amino-1,10-phenanthroline, 5-isothiocyanato-1,10-phenanthroline.

Biochem/physiol Actions

Platinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of cytotoxicity.

Synthesis

66-71-7

4199-88-6

General procedure for the synthesis of 5-nitro-1,10-o-phenanthroline from 1,10-phenanthroline: 1,10-phenanthroline (10 g, 55.49 mmol) was slowly added to fuming nitric acid (10 ml), which was subsequently dissolved in concentrated sulfuric acid (20 ml). The reaction was stirred at 160°C for 3 hours. After completion of the reaction, the reaction mixture was diluted with ice water and the pH was adjusted with saturated aqueous sodium hydroxide solution to 3. The resulting yellow solid was collected by filtration, washed with water and finally concentrated under reduced pressure to give 5-nitro-1,10-phenanthroline (6.2 g, 99% yield).

Purification Methods

Crystallise the phenanthroline from *benzene/pet ether, until anhydrous. It also crystallises from H2O with m 202o, and EtOAc with m 203o. Its pK2 5 varies from 3.20 to 2.69 with varying MeOH/H2O ratios from 0 to 0.95 moles/L, and from 3.20 to 1.95 in varying EtOH/H2O ratios from 0 to 0.94 moles/L [Ram et al. J Prakt Chem 319 719 1977]. It forms complexes with Cu2+, Zn2+, In2+, Fe2+ , Co2+, Ni2+ . [Beilstein 23 III/IV 1682, 23/8 V 425.]

References

[1] Organic Letters, 2010, vol. 12, # 12, p. 2876 - 2879
[2] Patent: KR101757629, 2017, B1. Location in patent: Paragraph 0135 - 0139
[3] Chemistry Letters, 2013, vol. 42, # 7, p. 700 - 702
[4] Supramolecular Chemistry, 2013, vol. 25, # 12, p. 798 - 805
[5] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 11,

5-Nitro-1,10-phenanthroline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-Nitro-1,10-phenanthroline Suppliers

Americas 1 Austria 1 Belgium 1 Canada 1 CHINA 172 Europe 1 Germany 3 India 5 Japan 2 Switzerland 2 United Kingdom 9 United States 26 Global 224

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Labseeker Inc

Tel: --
Fax: --
Email: marketing@labseeker.com
Country: United States
ProdList: 1495
Advantage: 55

Lab Express

Tel: --
Fax: --
Email: sales@labexpress.com
Country: United States
ProdList: 1577
Advantage: 67

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Atlantic SciTech Group, Inc.

Tel: --
Fax: --
Email: sales@astginc.com
Country: United States
ProdList: 2308
Advantage: 43

Eastar Chemical Corporation

Tel: --
Fax: --
Email: info@eastarchem.com
Country: United States
ProdList: 129
Advantage: 38

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

TimTec Corporation

Tel: --
Fax: --
Email: info@timtec.net
Country: United States
ProdList: 6891
Advantage: 68

Pfaltz & Bauer, Inc.

Tel: --
Fax: --
Email: sales@pfaltzandbauer.com
Country: United States
ProdList: 6828
Advantage: 72

GFS Chemicals

Tel: --
Fax: --
Email: gfschem@gfschemicals.com
Country: United States
ProdList: 3403
Advantage: 75

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

More

Less

View Lastest Price from 5-Nitro-1,10-phenanthroline manufacturers

Shanghai UCHEM Inc.

Product: 5-Nitro-1,10-phenanthroline 4199-88-6
Price: US $32.00-423.00/g
Min. Order: 1g
Purity: 0.98
Supply Ability: 10kg
Release date: 2023-10-17

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Nitro-1,10-phenanthroline 4199-88-6
Price: US $1.00-45.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-01

Career Henan Chemical Co

Product: 5-Nitro-1,10-phenanthroline 4199-88-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

4199-88-6, 5-Nitro-1,10-phenanthrolineRelated Search:

4-Nitrobenzoic acid Ferrous sulfate heptahydrate 2-Nitrotoluene 3-Nitroacetophenone 2-Nitrobenzaldehyde 1,7-PHENANTHROLINE 3-METHYLADENINE 2-Nitrobenzoic acid 1-Fluoro-2-nitrobenzene 2-Nitrobenzyl alcohol o-Phenanthroline 1,10-Phenanthroline hydrate Nitroethane 2-Nitrochlorobenzene Nitromethane 4-Nitroaniline 2-Nitrophenol Nitrazepam

5-NITRO-1,10-PHENANTHROLINE

5-nitro-10-phenanthroline

NITROFERROIN

TIMTEC-BB SBB008850

5-NITRO-1 10-PHENANTHROLINE HYDRATE &

5-Nitro-1,10-phenanthroline,98%

1,10-Phenanthroline, 5-nitro-

5-Nitro-1,10-phenathroline

5-Nitro-1, 10-diazaphenanthrene

5-Nitro-1

PHEN081, 5-Nitro-1,10-phenanthroline

5-Nitro-1,10-phenanthroline&gt

5-NP

5-Nitro-1,10-phenanthroline, 10 mM in DMSO

5-Nitro-1,10-phenanthroline - [N72178]

5-Nitro-1,10-phenthroline

4199-88-6

C12H7N3O2

NO2C12H7N2

Biochemicals and Reagents

BioChemical

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Type

Substrate Analogs