ChemicalBook > CAS DataBase List > TETRAHYDRO-2H-PYRAN-3-OL

TETRAHYDRO-2H-PYRAN-3-OL

Product Name
TETRAHYDRO-2H-PYRAN-3-OL
CAS No.
19752-84-2
Chemical Name
TETRAHYDRO-2H-PYRAN-3-OL
Synonyms
oxan-3-ol;DK653;3-Hydroxy-2H-pyran;TETRAHYDRO-PYRAN-3-OL;Pyran-3-ol, tetrahydro-;TETRAHYDRO-2H-PYRAN-3-OL;3-Hydroxytetrahydropyran;(s)-Tetrahydro-pyran-3-ol;3-Hydroxytetrahydropyrane;2H-Pyran-3-ol, tetrahydro-
CBNumber
CB9748231
Molecular Formula
C5H10O2
Formula Weight
102.13
MOL File
19752-84-2.mol
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TETRAHYDRO-2H-PYRAN-3-OL Property

Boiling point:
88 °C(Press: 18 Torr)
Density 
1.080±0.06 g/cm3(Predicted)
refractive index 
1.457
storage temp. 
2-8°C
pka
14.49±0.20(Predicted)
form 
liquid
color 
Colourless to light yellow
InChI
InChI=1S/C5H10O2/c6-5-2-1-3-7-4-5/h5-6H,1-4H2
InChIKey
BHDLTOUYJMTTTM-UHFFFAOYSA-N
SMILES
C1OCCCC1O
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Safety

HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
T294700
Product name
Tetrahydropyran-3-ol
Packaging
100mg
Price
$165
Updated
2021/12/16
Matrix Scientific
Product number
073867
Product name
Tetrahydro-2H-pyran-3-ol
Purity
95+%
Packaging
1g
Price
$125
Updated
2021/12/16
Ark Pharm
Product number
P000067430
Product name
Tetrahydro-2H-pyran-3-ol
Purity
97%
Packaging
10g
Price
$188
Updated
2021/12/16
Matrix Scientific
Product number
073867
Product name
Tetrahydro-2H-pyran-3-ol
Purity
95+%
Packaging
5g
Price
$400
Updated
2021/12/16
Apolloscientific
Product number
OR46583
Product name
3-Hydroxy-2H-pyran
Packaging
1g
Price
$51
Updated
2021/12/16
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TETRAHYDRO-2H-PYRAN-3-OL Chemical Properties,Usage,Production

Uses

Tetrahydro-2H-pyran-3-ol is a 3-substituted tetrahydropyran used in the preparation of herbicides as well as pyrazolothiazole compounds as CRF1 (corticotropin-releasing factor type 1) receptor antagonists.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 2282, 1970 DOI: 10.1021/jo00832a038

Synthesis

110-87-2

19752-84-2

Under nitrogen protection, 3,4-dihydro-2H-pyran (840 g, 10 mol) was dissolved in 4000 g of anhydrous tetrahydrofuran and cooled to 0 °C. A 1M borane tetrahydrofuran complex solution (6000 mL, 6 mol) was added dropwise at 0 °C and stirring was maintained. Subsequently, the reaction mixture was slowly cooled from room temperature to 0 °C over a period of 2 h and 3000 g of 20% NaOH aqueous solution was added dropwise. After the dropwise addition, hydrogen peroxide (1700 g, 15 mol) was added dropwise, the reaction temperature was controlled at 48 °C and stirred at room temperature for 9 hours. Upon completion of the reaction, saturated Na2S2O3 solution was added to quench the hydrogen peroxide, followed by concentration. The aqueous phase was extracted three times with 2000 g of dichloromethane, and the organic phases were combined, dried and concentrated. Finally, distillation was carried out under reduced pressure by pumping and the fractions were collected at an oil bath temperature of 140 °C and a fraction temperature of 100 °C to give 550 g of a colorless oily liquid with a purity of 98% and a yield of 52.8%.

References

[1] Journal of the Chemical Society, Chemical Communications, 1987, p. 1857 - 1859
[2] Patent: CN107382928, 2017, A. Location in patent: Paragraph 0007; 0010; 0013
[3] Patent: CN104650049, 2018, B. Location in patent: Paragraph 0599; 0600
[4] Canadian Journal of Chemistry, 1983, vol. 61, p. 1924 - 1932
[5] Liebigs Annalen der Chemie, 1983, # 11, p. 1950 - 1958

TETRAHYDRO-2H-PYRAN-3-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TETRAHYDRO-2H-PYRAN-3-OL manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tetrahydropyran-3-ol 19752-84-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Career Henan Chemical Co
Product
TETRAHYDRO-PYRAN-3-OL 19752-84-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500kg
Release date
2018-08-16

19752-84-2, TETRAHYDRO-2H-PYRAN-3-OLRelated Search:

TETRAHYDRO-PYRAN-3-CARBALDEHYDE TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID 2H-PYRAN-3(4H)-ONE, DIHYDRO- Tetrahydropyran-4-boronic acid pinacol ester Tetrahydro-2H-pyran-4-carbonyl chloride Tetrahydro-4-pyranol Methyl tetrahydropyran-4-carboxylate Tetrahydro-2H-pyran-4-carboxylic acid TETRAHYDRO-3-FUROIC ACID TETRAHYDROPYRAN-4-BORONIC ACID 4-Amidinotetrahydro-2H-pyran hydrochloride Methyl tetrahydro-3-furoate 2-Furamide,tetrahydro-(6CI,7CI) Tetrahydro-2-furancarboxaldehyde TETRAHYDRO-FURAN-3-CARBONYL CHLORIDE TETRAHYDROFURAN-3-BORONIC ACID PINACOL ESTER TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER Tetrahydropyran-4-SulfonylChloride

  • TETRAHYDRO-PYRAN-3-OL
  • 3-Hydroxytetrahydropyran
  • TETRAHYDRO-2H-PYRAN-3-OL
  • 3-Hydroxy-2H-pyran
  • 2H-Pyran-3-ol, tetrahydro-
  • Pyran-3-ol, tetrahydro-
  • Tetrahydro-2H-Pyran-3-Ol(WX642095)
  • 3-Hydroxytetrahydropyrane
  • oxan-3-ol
  • (s)-Tetrahydro-pyran-3-ol
  • (+)-3-Hydroxytetrahydro-2H-pyran
  • DK653
  • 19752-84-2
  • Aliphatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals