ChemicalBook > CAS DataBase List > 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

Product Name
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
CAS No.
86499-96-9
Chemical Name
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
Synonyms
3-BroMo-2;IHT-PI BBC;3-Bromo-2,3,4,5-tetr;A-BROMOBENZOCAPROLACTAM;3-bromobenzocaprolactam;α-Bromobenzocaprolactam;ALPHA-BROMOBENZO-CAPROLACTAM;3-Bromo-2,3,4,5-tetrahydro-2H-;3-BromoTetrahydrobenazepin-2-One;5-Trtrahydro-2H-1-benzazepine-2-one
CBNumber
CB9777910
Molecular Formula
C10H10BrNO
Formula Weight
240.1
MOL File
86499-96-9.mol
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Property

Melting point:
164 °C
Boiling point:
383.2±42.0 °C(Predicted)
Density 
1.492±0.06 g/cm3(Predicted)
Flash point:
185.542℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
slightly soluble in ethanol, benzene, acetone, insoluble in water
pka
13.59±0.40(Predicted)
InChI
InChI=1S/C10H10BrNO/c11-8-6-5-7-3-1-2-4-9(7)12-10(8)13/h1-4,8H,5-6H2,(H,12,13)
InChIKey
JMXPGCGROVEPID-UHFFFAOYSA-N
SMILES
N1C2=CC=CC=C2CCC(Br)C1=O
CAS DataBase Reference
86499-96-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3393
Product name
3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
Purity
>98.0%(GC)
Packaging
5g
Price
$27
Updated
2021/12/16
TCI Chemical
Product number
B3393
Product name
3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
Purity
>98.0%(GC)
Packaging
25g
Price
$81
Updated
2021/12/16
TRC
Product number
B688283
Product name
3-Bromo-1,3,4,5-tetrahydro-2h-1-benzazepin-2-one
Packaging
250mg
Price
$55
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021162
Product name
3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
Purity
95.00%
Packaging
1G
Price
$618.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021162
Product name
3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
Purity
95.00%
Packaging
5G
Price
$814.97
Updated
2021/12/16
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Chemical Properties,Usage,Production

Uses

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is an intermediate in the synthesis of Benazepril Hydrochloride. Benazepril Hydrochloride is a first-line antihypertensive drug recommended by the WHO. It is a chiral drug with excellent clinical efficacy, strong safety and tiny side effects in the international antihypertensive drugs of angiotensin converting enzyme inhibitors.

Chemical Properties

White or almost white crystalline

Preparation

The preparation of 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is as follows:10 parts by weight of the heated melted polyphosphoric acid was added to the drying kettle, With stirring, The above 2-bromo-3,4-dihydro-N-hydroxy- (2H) -naphthalimide was added in portions at a temperature of 60 ° C, Insulation reaction for 20 hours; The reaction solution was added dropwise to 12.5 parts by weight of water to carry out hydrolysis, Still Washed to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one crude; 10 parts by weight of methanol and 0.1 part by weight of activated carbon were added, Heating decolorization, After filtration, the filtrate was cooled to 10 ° C for 20 hours, centrifuged, washed and dried to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one. The purity of the product was 3, 10-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one as high as 99.6% and the yield was as high as 98%.

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Suppliers

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View Lastest Price from 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-10-23
Henan Fengda Chemical Co., Ltd
Product
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16
Changzhou Rokechem Technology Co., Ltd.
Product
3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99%;USP/EP/CP
Supply Ability
1-10000kgs
Release date
2023-05-26

86499-96-9, 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-oneRelated Search:

Benzo[b]thien-2-ylboronic acid 2-Bromoethylamine hydrobromide Tetrahydro-4H-pyran-4-one 3-Bromoanisole N-Methyl-2-pyrrolidone Epiandrosterone acetate 4'-Bromoacetophenone 2-Bromoacetophenone Laurocapram Dehydroepiandrosterone Phosphorus oxybromide Bromine 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one 2-bromo-N-(o-tolyl)propionamide 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Nitrogen and hydrogen mixed gas Tetrahydro

  • Intermediate 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
  • 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-one
  • 3-bromo-1,3,4,5-tetrahydro-1-benzazepin-2-one
  • 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-on
  • A-BROMOBENZOCAPROLACTAM
  • ALPHA-BROMOBENZO-CAPROLACTAM
  • 3-Bromobenzocaprolactam 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
  • 3-Bromo-1,3,4,5-tetrahydro-2<i>H</i>-1-benzazepin-2-one
  • 3-bromobenzocaprolactam
  • 3-bromo-1,3,4,5-tetrahdro-2h-benzazepin-2-one
  • 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
  • 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE
  • 3-BROMO-1,3,4,5-TETRAHYDRO-2H-L-BENZAZEPIN-2-ONE
  • 3-BROMO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE
  • 3-BROMO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-2-ONE
  • 3-BROMO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
  • 3-BROMO-2,3,4,5-TETRAHYDRO-2H-BENZO[B]AZEPIN-2-ONE
  • 3-BROMO-2,3,4,5-TETRAHYDRO-2-OXO-1H-1-BENZAZEPINE
  • 3-BROMO-2,3,4,5-TRTRAHYDRO-2H-1-BENZAZEPINE-2-ONE
  • 5-tetrahydro-2H-benzo[b]azepin-2-one
  • 3-BROMO-1,3,4,5-TETRAHYDRO-2H-BENZAZEPIN-2-ONE
  • 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAEPINE-2-ONE
  • 3-BBC: 3-BROMO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONE
  • 3-BROMO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE
  • 3-Bromo-2,3,4,5-tetrahydro-2H-
  • 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE HPLC +99.0%
  • 3-BromoTetrahydrobenazepin-2-One
  • 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE (3-BROMO LACTAM)
  • α-Bromobenzocaprolactam
  • 3-bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one
  • IHT-PI BBC
  • 3-Bromo-2,3,4,5-tetr
  • 3-BroMo-2
  • 5-Trtrahydro-2H-1-benzazepine-2-one
  • 2H-1-Benzazepin-2-one, 3-broMo-1,3,4,5-tetrahydro-
  • 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one &gt
  • 3-Bromo-2,3,4,5-tetrahydro-2-h-1-benzacepin–2one
  • 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one USP/EP/BP
  • 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
  • 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one (Benazepril API KSM)
  • 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one (Alpha-Bromolactum)
  • 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzoazo-2-one
  • 3-Bromo-1,3,4,5-tetrahydro-2-h-1-benzacepin–2one
  • 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one / Benazepril intermediate
  • 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazazole-2-one
  • 86499-96-9
  • 65-71-6
  • 68499-96-9
  • 96499-96-9
  • C10H10BrNO
  • C10H10NOBr
  • pharmacetical
  • 86499-96-9
  • john's