Uses
ChemicalBook > CAS DataBase List > 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-

1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-

Uses
Product Name
1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-
CAS No.
68618-36-0
Chemical Name
1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-
Synonyms
3-Bromo-7-azaindazole;7-Aza-3-bromo-1H-indazole;3-Bromo-7-aza-1H-indazole;3-Bromo-1H-pyrazolo[3,4-b...;3-Bromopyrazolo[3,4-b]pyridine;3-broMo-2h-pyrazolo[3,4-b]pyridine;3-Bromo-1H-pyrazolo[3,4-b]pyridine;1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-;3-Bromo-1H-pyrazolo[3,4-b]pyridine ,97%;3-Bromo-1H-pyrazolo[3,4-b]pyridine
CBNumber
CB9837230
Molecular Formula
C6H4BrN3
Formula Weight
198.02
MOL File
68618-36-0.mol
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1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO- Property

Melting point:
170-171 °C
Boiling point:
296.9±23.0 °C(Predicted)
Density 
2.00±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
4.09±0.20(Predicted)
color 
Light yellow
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Safety

Hazard Codes 
T
Risk Statements 
25-20/21/22
Safety Statements 
45-36/37
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BLN00006
Product name
3-Bromo-1H-pyrazolo[3,4-b]pyridine
Purity
Aldrich
Packaging
1g
Price
$475
Updated
2025/07/31
TRC
Product number
B699738
Product name
3-Bromo-1H-pyrazolo[3,4-b]pyridine
Packaging
100mg
Price
$75
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
B12214
Product name
3-Bromo-1H-pyrazolo[3,4-b]pyridine
Packaging
5g
Price
$89
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
B12214
Product name
3-Bromo-1H-pyrazolo[3,4-b]pyridine
Packaging
1g
Price
$23
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB130789
Product name
3-Bromo-1H-pyrazolo[3,4-b]pyridine
Packaging
100mg
Price
$58
Updated
2021/12/16
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1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO- Chemical Properties,Usage,Production

Uses

3-Bromo-1H-pyrazolo[3,4B]pyridine is used as a pharmaceutical intermediate.

Chemical Properties

Light yellow solid

Biological Activity

1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO- is a pyrimidine derivative that acts as a stimulant. It has been shown to cause pulmonary hypertension in rats and has been used to induce pulmonary hypertension in rats. This drug has also been shown to have an effect on the rat heart and is being researched for its biological profiles.

Synthesis

271-73-8

68618-36-0

The general procedure for the synthesis of 3-bromo-1H-pyrazolo[3,4-b]pyridine using 1H-pyrazolo[3,4-b]pyridine as starting material was as follows: bromine (1.91 mL, 37.1 mmol) was slowly added dropwise to a solution of 1H-pyrazolo[3,4-b]pyridine (2.6 g, 21.8 mmol) dissolved in chloroform (100 mL). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was concentrated to remove the solvent. The concentrated residue was dissolved in a mixture of ethyl acetate (200 mL) and saturated sodium bicarbonate solution (50 mL). The aqueous layer was extracted twice with ethyl acetate (50 mL). All organic layers were combined, dried over anhydrous sodium sulfate, filtered to remove the desiccant, and the filtrate was subsequently concentrated to afford 3-bromo-1H-pyrazolo[3,4-b]pyridine (3.7 g, 86% yield) as a solid product.

References

[1] Patent: WO2009/111279, 2009, A1. Location in patent: Page/Page column 81
[2] Canadian Journal of Chemistry, 1988, vol. 66, # 3, p. 420-428
[3] Patent: WO2012/83117, 2012, A1. Location in patent: Page/Page column 126-127
[4] Patent: WO2018/13867, 2018, A1. Location in patent: Paragraph 506

1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO- Preparation Products And Raw materials

Raw materials

3-Aminopyrazole Ethanol Zinc chloride Chloroform Bromine 1,1,3,3-Tetramethoxypropane

Preparation Products

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View Lastest Price from 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO- manufacturers

Career Henan Chemical Co
Product
1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO- 68618-36-0
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

68618-36-0, 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-Related Search:

3-broMo-2-Methylquinoline 3-BROMO-2-CHLOROBENZONITRILE 3-Bromo-2-pyridinecarboxaldehyde 3-BroMo-2,4-difluoropyridine 3-Bromo-4-chloroindole 3-BROMO-2-CHLOROBENZOIC ACID 3-Bromo-2-hydroxy-5-iodopyridine 3-Bromo-1,8-naphthyridine 3-BROMO-2-CHLOROPHENYLBORONIC ACID 3-BROMO-4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 3-Bromo-2-nitrophenol 3-BROMO-2,5-DIAMINOPYRIDINE 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine 3-BROMO-4-NITROPYRIDINE 3-bromo-1H-pyrazolo[4,3-c]pyridine 3-BROMO-4,7-DIAZAINDOLE 1H-PYRAZOLO[3,4-B]PYRIDINE 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-

  • 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-
  • 3-Bromo-1H-pyrazolo[3,4-b]pyridine ,97%
  • 7-Aza-3-bromo-1H-indazole
  • 3-Bromo-7-azaindazole
  • 3-broMo-2h-pyrazolo[3,4-b]pyridine
  • 3-Bromo-7-aza-1H-indazole
  • 3-Bromo-1H-pyrazolo[3,4-b]pyridine
  • 3-Bromo-1H-pyrazolo[3,4-b...
  • 3-Bromopyrazolo[3,4-b]pyridine
  • 3-Bromo-1<i>H</i>-pyrazolo[3,4-b]pyridine
  • 68618-36-0