ChemicalBook > CAS DataBase List > 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE

1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE

Product Name
1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE
CAS No.
284028-90-6
Chemical Name
1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE
Synonyms
DR 2313;IR 2313;SC-202756;DR2313 >=98% (HPLC);PARP Inhibitor XI, DR2313;4H-Thiopyrano[4,3-d]pyriMidin-4-one,3,5,7,8-tetrahydro-2;DR2313 (PARP Inhibitor XI), brain-penetrant PARP inhibitor;7,8-Dihydro-2-methyl-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one;3,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one;1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE
CBNumber
CB9837735
Molecular Formula
C8H10N2OS
Formula Weight
182.24
MOL File
284028-90-6.mol
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1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Property

Boiling point:
349.3±52.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
H2O: >2mg/mL (warmed)
form 
powder
pka
1.54±0.20(Predicted)
color 
white to beige
Water Solubility 
H2O: >2mg/mL (warmed)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0397
Product name
DR2313
Purity
≥98% (HPLC)
Packaging
5mg
Price
$78.3
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0397
Product name
DR2313
Purity
≥98% (HPLC)
Packaging
25mg
Price
$337
Updated
2022/05/15
Cayman Chemical
Product number
21181
Product name
DR2313
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21181
Product name
DR2313
Purity
≥98%
Packaging
5mg
Price
$74
Updated
2024/03/01
Cayman Chemical
Product number
21181
Product name
DR2313
Purity
≥98%
Packaging
10mg
Price
$122
Updated
2024/03/01
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1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Chemical Properties,Usage,Production

Biological Activity

Potent, competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC 50 values are 0.20 and 0.24 μ M for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro . Brain penetrant.

1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Suppliers

China 88 Germany 1 India 1 Switzerland 1 The Netherlands 1 United Kingdom 1 United States 14 Global 107
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View Lastest Price from 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE manufacturers

Career Henan Chemical Co
Product
1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE 284028-90-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-31

284028-90-6, 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONERelated Search:

4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 4-Hydroxyquinazoline Rucaparib DPQ ABT-888 PJ-34 PF-01367338 Benzamide Minocycline hydrochloride 1,5-ISOQUINOLINEDIOL 1(2H)-Isoquinolinone, 5-aMino-, Monohydrochloride 5-Benzoyloxy-1(2H)-isoquinolinone 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE

  • 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE
  • DR 2313
  • 7,8-Dihydro-2-methyl-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one
  • 3,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one
  • 4H-Thiopyrano[4,3-d]pyriMidin-4-one,3,5,7,8-tetrahydro-2
  • 4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE,3,5,7,8-TETRAHYDRO-2-METHYL-
  • SC-202756
  • 2-Methyl-1-sulfanyl-1H,4H,5H,7H,8H-pyrano[4,3-d]pyriMidin-4-one
  • PARP Inhibitor XI, DR2313
  • IR 2313
  • 3,5,7,8-tetrahydro-2-methyl-4h-thiopyrano(4,3-d)pyrimidin-4-one, 98%(HPLC)
  • DR2313 >=98% (HPLC)
  • DR2313 (PARP Inhibitor XI), brain-penetrant PARP inhibitor
  • 284028-90-6