ChemicalBook > CAS DataBase List > MANZAMINE A

MANZAMINE A

Product Name
MANZAMINE A
CAS No.
104196-68-1
Chemical Name
MANZAMINE A
Synonyms
MANZAMINE A;Keramamine A;1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-
CBNumber
CB9838727
Molecular Formula
C36H44N4O
Formula Weight
548.76
MOL File
104196-68-1.mol
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MANZAMINE A Property

Melting point:
＞240(disassembly)
Boiling point:
756.6±60.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
-20°
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
Off white to yellow solid.
pka
13.58±0.40(Predicted)
color 
Off-White to Pale Yellow
optical activity
+5020 (CHCl3)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21444
Product name
Manzamine A
Purity
≥98%
Packaging
500μg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
21444
Product name
Manzamine A
Purity
≥98%
Packaging
1mg
Price
$232
Updated
2024/03/01
TRC
Product number
M186003
Product name
ManzamineA
Packaging
2.5mg
Price
$795
Updated
2021/12/16
Adipogen Life Sciences
Product number
AG-CN2-0438-C500
Product name
ManzamineA
Purity
≥98%(HPLC)
Packaging
500μg
Price
$140
Updated
2021/12/16
Biorbyt Ltd
Product number
orb546096
Product name
Manzamine A
Purity
>98%
Packaging
1mg
Price
$365.5
Updated
2021/12/16
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MANZAMINE A Chemical Properties,Usage,Production

Description

Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis?in vivo2. Manzamine A displays neuritogenic activity3?and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4.

Uses

Manzamine A is a β-Carboline alkaloid with anti-inflammatory.

Definition

ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).

storage

+4°C

References

1) Kallifatidis?et al. (2013),?The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells; Mar. Drugs,?11?3500 2) Eguchi?et al. (2013),?Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo; Bioorg. Med. Chem.,?21?3831 3) Zhang?et al. (2008),?Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. Igens (Thiele, 1899); Chem. Pharm. Bull.,?56?866 4) Hamann?et al. (2007),?Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease; J. Nat. Prod.,?70 139

MANZAMINE A Preparation Products And Raw materials

Raw materials

Preparation Products

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MANZAMINE A Suppliers

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104196-68-1, MANZAMINE ARelated Search:

OUABAIN OCTAHYDRATE AR-A014418 SB216763 Ethacrynic acid 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE SB 415286 1-AZAKENPAULLONE KAHWEOL SEDANOLIDE S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE CAFESTOL 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE (R)-TERT-LEUCINOL 3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-OL 4-PYRIDIN-2-YL-BUTYLAMINE MANZAMINE A N,N-DIBUTYL-2-ETHYLHEXYLAMINE manzamine F

  • MANZAMINE A
  • 1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-
  • Keramamine A
  • 104196-68-1
  • C36H44N4O