Scopine-2,2-dithienyl glycolate
Description- Product Name
- Scopine-2,2-dithienyl glycolate
- CAS No.
- 136310-64-0
- Chemical Name
- Scopine-2,2-dithienyl glycolate
- Synonyms
- N-DeMethyl TiotropiuM;N-Desmethyl Tiotropium;Tiotropium EP Impurity B;SCOPINE-2,2-DITHIENYL GLYCOLATE;Tiotropium Bromide EP Impurity B;Scopolamine 2-(2-thienyl)glycolate;CO base bis (2-thiophenyl) glycolate;Scopolamine 2- (2-thiophenyl) glycolate;Scopine-2,2-dithienyl glycolate USP/EP/BP;Tiotropium Bromide Monohydrate Impurity B
- CBNumber
- CB9843604
- Molecular Formula
- C18H19NO4S2
- Formula Weight
- 377.48
- MOL File
- 136310-64-0.mol
Scopine-2,2-dithienyl glycolate Property
- Melting point:
- 138-140°C
- Boiling point:
- 542.3±50.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 10.32±0.29(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S199965
- Product name
- ScopineDi(2-thienylglycolate)
- Packaging
- 10mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 090317
- Product name
- Scopine di(2-thienyl)glycolate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $378
- Updated
- 2021/12/16
- Product number
- IS145668
- Product name
- Scopine-2,2-dithienyl glycolate
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- I986
- Product name
- Scopine-2,2-dithienylglycolate
- Packaging
- 1g
- Price
- $551
- Updated
- 2021/12/16
- Product number
- IS145668
- Product name
- Scopine-2,2-dithienyl glycolate
- Packaging
- 2g
- Price
- $630
- Updated
- 2021/12/16
Scopine-2,2-dithienyl glycolate Chemical Properties,Usage,Production
Description
Scopine-2,2-dithienyl glycolate is an organic compound. It is off-white solid. The melting point is 138-140°C. The storage temperature is -20°C. Scopine-2,2-dithienyl glycolate is one of the reaction intermediates in the preparation of tiotropium bromide, which is a highly effective anticholinergic agent and widely used for treatment of asthma and/or chronic obstructive pulmonary disease (COPD) (chronic obstructive pulmonary disease).
Chemical Properties
Off-White Solid
Uses
Scopine Di(2-thienylglycolate) (Tiotropium EP Impurity B) is a precursor to Tiotropium Bromide.
Synthesis
26447-85-8
498-45-3
136310-64-0
Example 1: 7 mol% NHC (relative to compound (1)) in THF at room temperature. In an anhydrous flask containing about 7.85 g of activated 4A molecular sieves, methyl 2,2-dithienylglycolate (2) (R = Me, 3.97 g, 15.6 mmol) and rel-(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol (1) (2.61 g. 16.8 mmol) was dissolved in THF (14 mL). Another flask was taken and 1-butyl-3-methylimidazolium tetrafluoroborate (210 μL, 1.12 mmol), KOtBu/THF solution (960 μL, 0.96 mmol), and THF (1.0 mL) were added, and stirred for 15 min at room temperature. Subsequently, this mixture was transferred to a flask containing rel-(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol solution using a syringe. The syringe and flask were washed with THF (2 x 0.5 mL) and the reaction mixture was stirred at room temperature for 18 h. HPLC analysis showed 86% yield of the expected product.After 18 h, the mixture was filtered and the molecular sieves were washed with THF (2 x 20 mL). The filtrate was concentrated to dryness and the residue was dissolved in toluene (30 mL) and 1M HCl (30 mL). Solid precipitation was observed during phase separation; the suspension was filtered and the solids were washed with toluene (30 mL) and redissolved in the separated aqueous phase. The aqueous phase suspension was cooled to 0 °C and alkalized to the proper pH by adding solid K2CO3. The mixture was stirred at 0 °C for about 30 min, and the resulting solid was filtered, washed with cold water, and dried first on a filter, followed by vacuum drying at 45 °C for 18 h to give the white solid product (3) (4.30 g, 73%, HPLC purity = 99.89%).
References
[1] Patent: WO2013/46138, 2013, A1. Location in patent: Page/Page column 9; 10
[2] Patent: US2004/242622, 2004, A1. Location in patent: Page 29
[3] ChemMedChem, 2017, vol. 12, # 15, p. 1173 - 1182
[4] Patent: US2014/303373, 2014, A1. Location in patent: Paragraph 0034; 0035; 0036; 0037
Scopine-2,2-dithienyl glycolate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Scopine-2,2-dithienyl glycolate manufacturers
- Product
- Scopine-2,2-dithienyl glycolate 136310-64-0
- Price
- US $25.00/PCS
- Min. Order
- 100g
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2021-06-10
- Product
- Scopine-2,2-dithienyl glycolate 136310-64-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- Scopine-2,2-dithienyl glycolate 136310-64-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100tons
- Release date
- 2023-09-18