Hydroxysafflor yellow A

Product Name: Hydroxysafflor yellow A
CAS No.: 78281-02-4
Chemical Name: Hydroxysafflor yellow A
Synonyms: HSYA;SAFFLOMIN A;Hydroxysafflor yellow;Hydroxysafflor yellow A;Hydroxysafflor yellow A-RM;Hydroxy safflower yellow pigment A;Hydroxylsafflower yellow pigment A;Hydroxysafflor yellow A,Safflomin A;Hydroxysafflor yellow A, 10 mM in DMSO;Hydroxysafflor yellow A,SaffloMin A,HSYA
CBNumber: CB9843710
Molecular Formula: C27H32O16
Formula Weight: 612.54
MOL File: 78281-02-4.mol

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Hydroxysafflor yellow A Property

Melting point:: 184-186 °C
Boiling point:: 1015.8±65.0 °C(Predicted)
Density: 1.851±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 1 mg/ml; DMSO: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
pka: 4.50±1.00(Predicted)
form: powder
color: Yellow-orange
InChIKey: LIPJRCGLQNIXGO-KGDWUUGINA-N
LogP: 1.688 (est)

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Safety

Safety Statements: 24/25
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 300905
Product name: Safflomin A
Packaging: 20mg
Price: $405
Updated: 2021/12/16

Biosynth Carbosynth

Product number: OH08134
Product name: Hydroxysafflor yellow A
Packaging: 5mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: X1163
Product name: HydroxysaffloryellowA
Packaging: 5mg
Price: $49
Updated: 2021/12/16

Biosynth Carbosynth

Product number: OH08134
Product name: Hydroxysafflor yellow A
Packaging: 10mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-4544
Product name: HydroxysaffloryellowA
Purity: >98.0%
Packaging: 10mg
Price: $96
Updated: 2021/12/16

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Hydroxysafflor yellow A Chemical Properties,Usage,Production

Chemical Properties

Derived from the dried flowers of Carthamus tinctorius L.

Uses

Hydroxysafflor yellow A (Safflomin A) is a natural product of flavonoids isolated from safflower. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. Hydroxysafflor yellow A has anti-inflammatory, antioxidant and antitumor effects. Hydroxysafflor yellow A can be used in the study of cardiovascular disease[1][2][3][4][5][6].

Definition

ChEBI: Hydroxysafflor yellow A is a C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius). It has a role as an anti-inflammatory agent, an antioxidant, a platelet aggregation inhibitor, an antineoplastic agent, a radical scavenger, an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor, a neuroprotective agent and a plant metabolite. It is a C-glycosyl compound, a member of phenols, an enone and an enol.

Biological Activity

Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities. It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 μM.

in vivo

Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats. It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral is chemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.

References

[1] Yang G, et al. Hydroxysafflor yellow A inhibits lipopolysaccharide-induced proliferation and migration of vascular smooth muscle cells via Toll-like receptor-4 pathway. Int J Clin Exp Med. 2015 Apr 15;8(4):5295-302. PMID:26131104
[2] Zhu HJ, et al. Hydroxysafflor yellow A (HYSA) inhibited the proliferation and differentiation of 3T3-L1 preadipocytes. Cytotechnology. 2015 Oct;67(5):885-92. DOI:10.1007/s10616-014-9783-3
[3] Jin M, et al. Hydroxysafflor yellow A attenuate lipopolysaccharide-induced endothelium inflammatory injury. Chin J Integr Med. 2016 Jan;22(1):36-41. DOI:10.1007/s11655-015-1976-x
[4] He Y, et al. Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats. J Physiol Biochem. 2015 Mar;71(1):69-78. DOI:10.1007/s13105-015-0382-3
[5] Jin M, Xue et al. Protective Effect of Hydroxysafflor Yellow A on Inflammatory Injury in Chronic Obstructive Pulmonary Disease Rats. Chin J Integr Med. 2019 Oct;25(10):750-756. DOI:10.1007/s11655-018-2577-2
[6] Wu N, et al. Hydroxysafflor yellow A promotes apoptosis via blocking autophagic flux in liver cancer. Biomed Pharmacother. 2021 Apr;136:111227. DOI:10.1016/j.biopha.2021.111227

Hydroxysafflor yellow A Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydroxysafflor yellow A Suppliers

China 240 India 2 United States 16 Global 258

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View Lastest Price from Hydroxysafflor yellow A manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Hydroxysafflor yellow A 78281-02-4
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-12

Career Henan Chemical Co

Product: SAFFLOMIN A 78281-02-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

78281-02-4, Hydroxysafflor yellow ARelated Search:

Epmedin B Gallic acid monohydrate CALYCOSIN Isoalantolactone lithospermic acid Isoimperatorin AURANTIO-OBTUSIN Coumalic acid Cynaroside ARTEMISININ Gentiopicroside Resveratrol Linarin Schisandrin A Albiflorin FORSYTHIN Phloretin SAFFLOWER YELLOW

SAFFLOMIN A

Hydroxysafflor yellow A

2,5-Cyclohexadien-1-one, 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-((2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl)-

Hydroxysafflor yellow A,SaffloMin A,HSYA

Hydroxysafflor yellow A,Safflomin A

Hydroxysafflor yellow

Safflomin A, 98%, from Carthamus tinctorius L.

HSYA

2,5-Cyclohexadien-1-one, 2,4-di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-

3,4,5-Trihydroxy-2-((E)-3-(4-hydroxyphenyl)acryloyl)-4-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)cyclohexa-2,5-dien-1-one

Hydroxy safflower yellow pigment A

Hydroxylsafflower yellow pigment A

Hydroxysafflor yellow A-RM

Hydroxysafflor yellow A, 10 mM in DMSO

78281-02-4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract