ChemicalBook > CAS DataBase List > 2-Phenoxyethanol

2-Phenoxyethanol

Product Name
2-Phenoxyethanol
CAS No.
122-99-6
Chemical Name
2-Phenoxyethanol
Synonyms
PHENOXYETHANOL;Ethanol, 2-phenoxy-;PhG;Phenoxyethyl alcohol;ETHYLENE GLYCOL PHENYL ETHER;Arosol;PHENOXETOL;phenoxyethanol[qr];ROSE ETHER;Phenoxethol
CBNumber
CB9852958
Molecular Formula
C8H10O2
Formula Weight
138.16
MOL File
122-99-6.mol
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2-Phenoxyethanol Property

Melting point:
11-13 °C (lit.)
Boiling point:
247 °C (lit.)
Density 
1.102 g/mL at 25 °C (lit.)
vapor density 
4.8 (vs air)
vapor pressure 
0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.539
FEMA 
4620 | 2-PHENOXYETHANOL
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
soluble, clear, colorless to very faintly yellow
pka
14.36±0.10(Predicted)
form 
Liquid
color 
Clear colorless
Specific Gravity
1.109 (20/4℃)
Odor
Faint aromatic odor
PH Range
7 at 10 g/l at 23 °C
PH
7 (10g/l, H2O, 23℃)
explosive limit
1.4-9.0%(V)
Odor Type
floral
Water Solubility 
30 g/L (20 ºC)
Merck 
14,7257
BRN 
1364011
InChIKey
QCDWFXQBSFUVSP-UHFFFAOYSA-N
LogP
1.2 at 23℃
CAS DataBase Reference
122-99-6(CAS DataBase Reference)
NIST Chemistry Reference
2-Phenoxyethanol(122-99-6)
EPA Substance Registry System
Ethylene glycol monophenyl ether (122-99-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36-R36-R22
Safety Statements 
26-S26
WGK Germany 
1
RTECS 
KM0350000
Autoignition Temperature
535 °C DIN 51794
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29094990
Hazardous Substances Data
122-99-6(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.07291
Product name
Ethylene glycol monophenyl ether
Purity
for synthesis
Packaging
1L
Price
$72.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07291
Product name
Ethylene glycol monophenyl ether
Purity
for synthesis
Packaging
2.5L
Price
$104
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07291
Product name
Ethylene glycol monophenyl ether
Purity
for synthesis
Packaging
5L
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07291
Product name
Ethylene glycol monophenyl ether
Purity
for synthesis
Packaging
25kg
Price
$875
Updated
2024/03/01
Sigma-Aldrich
Product number
56753
Product name
2-Phenoxyethanol
Purity
analytical standard
Packaging
1mL
Price
$31
Updated
2024/03/01
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2-Phenoxyethanol Chemical Properties,Usage,Production

Description

Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.

Chemical Properties

clear colorless liquid

Chemical Properties

Phenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.

Characteristics

Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.

Uses

phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol.

Uses

Ethylene glycol phenyl ether at a 1.0% level acts as a preservative in personal care products.

Uses

Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.

Uses

Antimicrobial preservative; also used topically in treatment of bacterial infections.

Production Methods

Phenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.

Definition

ChEBI: 2-phenoxyethanol is an aromatic ether that is phenol substituted on oxygen by a 2-hydroxyethyl group. It has a role as an antiinfective agent and a central nervous system depressant. It is a primary alcohol, a glycol ether and an aromatic ether. It is functionally related to a phenol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 40, p. 1356, 1975 DOI: 10.1021/jo00897a043

General Description

Colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

Air & Water Reactions

Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.

Reactivity Profile

2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

Health Hazard

May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.

Fire Hazard

2-Phenoxyethanol is combustible.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Phenoxyethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%; it may also be used as a preservative and antimicrobial agent for vaccines.Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes.
Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,

Industrial uses

2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
2-Phenoxyethanol is not registered as a food additive in the EU.
Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).

Contact allergens

Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl? K 400) or with parabens. Sensitization to this molecule is very rare.

References

[1] Almut Khler, Karin Finger-Baier, Luis Antunes. "Chapter 16 - Anesthesia, restraint and analgesia in laboratory fishes." Anesthesia and Analgesia in Laboratory Animals (Third Edition) (2023): 393-409.

Side effects

2-phenoxyethanol is a colorless or straw-colored oily liquid with slight solubility in water but soluble in ethanol and is used as an immersion anesthetic. This agent has bactericidal and fungicidal properties and has been used as a topical anesthetic. This agent can provide deep stages of anesthesia and is relatively inexpensive. Nevertheless, it has no other significant advantages over other drugs. Using 2-phenoxyethanol can elicit several side effects, such as decreased respiratory and heart rate, reduced blood pressure and blood oxygenation, alterations of blood parameters, and elevated plasma levels of adrenaline, glucose, and cortisol, as shown in bighead carp. In addition, sustained and prolonged exposure to 2-phenoxyethanol can cause neuropsychological syndrome in handlers[1].

Safety Profile

Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.

Safety

Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants.
LD50 (rabbit, skin): 5 g/kg
LD50 (rat, oral): 1.26 g/kg

storage

Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.

Incompatibilities

The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.

2-Phenoxyethanol Preparation Products And Raw materials

Raw materials

ETHYLENE OXIDE

Preparation Products

Pyriproxyfen bis(2-phenoxyethyl) peroxydicarbonate impregnanting agent for leather Phenoxyethyl isobutyrate
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View Lastest Price from 2-Phenoxyethanol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Phenoxyethanol 122-99-6
Price
US $5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-19
HebeiShuoshengImportandExportco.,Ltd
Product
2-Phenoxyethanol 122-99-6
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-06
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Phenoxyethanol 122-99-6
Price
US $99.00-45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-11-14

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