Synthesis Chemical Properties Uses
ChemicalBook > CAS DataBase List > 1,3-Difluorobenzene

1,3-Difluorobenzene

Synthesis Chemical Properties Uses
Product Name
1,3-Difluorobenzene
CAS No.
372-18-9
Chemical Name
1,3-Difluorobenzene
Synonyms
M-DIFLUOROBENZENE;1,3-DifL;DIFLOUROBENZENE;m-difluoro-benzen;m-Difluro Benzene;1,3-Difluorbenzol;3-DifluoroBenzene;1?-Difluorobenzene;1,3-DIFLUOROBENZEN;Benzene,m-difluoro-
CBNumber
CB9853566
Molecular Formula
C6H4F2
Formula Weight
114.09
MOL File
372-18-9.mol
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1,3-Difluorobenzene Property

Melting point:
-59 °C
Boiling point:
83 °C
Density 
1.163 g/mL at 25 °C(lit.)
vapor pressure 
11.034-19.924kPa at 20-38.2℃
refractive index 
n20/D 1.438(lit.)
Flash point:
36 °F
storage temp. 
Flammables area
solubility 
1.1g/l
form 
Liquid
Specific Gravity
1.163
color 
Clear colorless to yellow
Water Solubility 
insoluble
BRN 
1904537
Dielectric constant
5.2400000000000002
LogP
2.21-2.52 at 25℃ and pH6.5
CAS DataBase Reference
372-18-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1,3-difluoro-(372-18-9)
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Safety

Hazard Codes 
F,Xn
Risk Statements 
11-20-2017/11/20
Safety Statements 
7-16-29-33-7/9
RIDADR 
UN 1993 3/PG 2
WGK Germany 
1
RTECS 
CZ5652000
Hazard Note 
Highly Flammable
HazardClass 
3
PackingGroup 
II
HS Code 
29036990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D102008
Product name
1,3-Difluorobenzene
Purity
≥99%
Packaging
10g
Price
$78.6
Updated
2024/03/01
Sigma-Aldrich
Product number
D102008
Product name
1,3-Difluorobenzene
Purity
≥99%
Packaging
100g
Price
$144
Updated
2024/03/01
TCI Chemical
Product number
D1626
Product name
1,3-Difluorobenzene
Purity
>98.0%(GC)
Packaging
25g
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
D1626
Product name
1,3-Difluorobenzene
Purity
>98.0%(GC)
Packaging
500g
Price
$457
Updated
2024/03/01
Alfa Aesar
Product number
A14387
Product name
1,3-Difluorobenzene, 99%
Packaging
10g
Price
$54.65
Updated
2024/03/01
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1,3-Difluorobenzene Chemical Properties,Usage,Production

Synthesis

Higher yields were observed when CsF and HF were reacted with 1,3-dichlorobenzene, which gave I ,3-difluorobenzene.

Chemical Properties

1,3-Difluorobenzene (C6H4F2, CAS registry No. 372-18-9) is also named as m-difluorobenzene, which is a clear colorless to yellowish liquid. Its melting point is -59 °C, boiling point is 83 °C and flash point is 2 oC. It is insoluble in water and stable under normal temperatures and pressures. It is toxic and flammable. It will produce toxic fluoride gas by heat.

Uses

1,3-Difluorobenzene has been extensively used in the synthesis of pharmaceutical and pesticide intermediate. For example, it can be used for the synthesis of fluorinated medicine such as Fluconazole, etc. and pesticide (Flucycloxuron, Diflubenzuro, etc.). It can also be used to synthesize liquid crystal materials.

Chemical Properties

CLEAR COLORLESS TO YELLOWISH LIQUID

Uses

It is used in the laser induced fluorencence matrix study of 1,3-difluorobenzene radical cation. It is also used synthesis of 1,2,3-triazole containing fluconazole analogues.

Definition

ChEBI: A difluorobenzene carrying fluoro groups at positions 1 and 3.

1,3-Difluorobenzene Preparation Products And Raw materials

Raw materials

Sodium nitrite Fluoroboric acid Hydrochloric acid m-Phenylenediamine 3-Nitroaniline

Preparation Products

2,4-Difluoronitrobenzene 2,6-Difluorophenol 1-Bromo-2,4-difluorobenzene Fluconazole 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Risperidone
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1,3-Difluorobenzene Suppliers

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View Lastest Price from 1,3-Difluorobenzene manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
1,3-Difluorobenzene 372-18-9
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-09-13
Hebei Chuanghai Biotechnology Co,.LTD
Product
1,3-Difluorobenzene 372-18-9
Price
US $10.60/KG
Min. Order
1KG
Purity
98%
Supply Ability
5000kg
Release date
2024-08-21
Hebei Weibang Biotechnology Co., Ltd
Product
1,3-Difluorobenzene 372-18-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2023-02-16

372-18-9, 1,3-Difluorobenzene Related Search:

2,6-Difluorophenol 4-Fluorobenzaldehyde α,α-Difluorophenylacetic acid Florfenicol 3,4-Difluorobenzonitrile 2,6-Difluorobenzamide 2,3-Difluorobenzoic acid Transfluthrin 2,3-Difluorophenol 2,6-Difluorobenzoic acid 2,6-Difluorobenzaldehyde 2,6-Difluorobenzonitrile 2-Difluorobenzene,1,2-Difluorobenzene 98%,1,2-Difluorobenzene,98+%,o-Difluorobenzene,99% Pentafluorobenzene DECAFLUOROBENZHYDROL 2',3',4',5',6'-PENTAFLUOROACETOPHENONE 2,3,4,5,6-PENTAFLUOROBENZOPHENONE DIPHENYL(PENTAFLUOROPHENYL)PHOSPHINE

  • 1,3-difluroethylene
  • Benzene, m-difluoro-
  • benzene,1,3-difluoro-
  • Benzene,m-difluoro-
  • Between two fluorine benzene
  • 1,3-DifL
  • Difluoro-1,3-benzene
  • m-difluoro-benzen
  • meta-Difluorobenzene
  • M-DIFLUOROBENZENE
  • 1?-Difluorobenzene
  • m-Difluro Benzene
  • 1,3-DIFLUOROBENZEN
  • 1,3-DIFLUOROBENZENE
  • 1,3-DIFLUOROBENZENE, 99+%
  • 1,3-DifluorobenzeneExtraPure
  • DIFLOUROBENZENE
  • 1,3-Difluorbenzol
  • 3-DifluoroBenzene
  • 1,3-DIFLUOROBENZENEFLOCONAZOLE
  • 1,3 DIFLOUROBENZENE extrapure
  • 1,3-difluoro (between the two fluorophenyl)
  • Between difluorobenzene
  • 1,3-Difluorobenzene, 99+% 10ML
  • 1,3-Difluorobenzene &gt
  • 1,3-Difluorobenzene ISO 9001：2015 REACH
  • 1,3-Difluorobenzene (MDFB) extrapure, 99%
  • Voriconazole Impurity 39
  • 1,3-Difluorobenzene 99% Extrapure
  • 372-18-9
  • C6H4F2CFCHCFCHCHCH
  • 372189
  • Building Blocks
  • Aryl
  • C6
  • Organic Building Blocks
  • Halogenated Hydrocarbons
  • Aryl Fluorinated Building Blocks
  • Building Blocks
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Halogenated Hydrocarbons
  • Organic Building Blocks
  • Organic Fluorinated Building Blocks
  • Other Fluorinated Organic Building Blocks
  • alkyl Fluorine
  • Aromatic Hydrocarbons (substituted) & Derivatives
  • Fluorobenzene
  • Fluorine Compounds
  • Aryl
  • C6
  • Halogenated Hydrocarbons
  • bc0001
  • K00001