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2-Nitrobenzoic acid

Product Name
2-Nitrobenzoic acid
CAS No.
552-16-9
Chemical Name
2-Nitrobenzoic acid
Synonyms
O-NITROBENZOIC ACID;2-nitrobenzoic;2-NITRODRACYLIC ACID;2-Nitrobenzoicacid,95%;Nitrobenzoic aci;2-nitro-benzoicaci;o-Nitrobenaoicacid;o-nitro-benzoicaci;RARECHEM AL BO 0202;ORTHO-NITROBENZOATE
CBNumber
CB9853809
Molecular Formula
C7H5NO4
Formula Weight
167.12
MOL File
552-16-9.mol
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2-Nitrobenzoic acid Property

Melting point:
146-148 °C(lit.)
Boiling point:
295.67°C (rough estimate)
Density 
1,58 g/cm3
refractive index 
1.6280 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
7.8g/l
form 
Fine Powder
pka
2.16(at 18℃)
color 
Off-white
Specific Gravity
1.58
Water Solubility 
6.8 g/L
Merck 
14,6588
BRN 
1910632
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
552-16-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 2-nitro-(552-16-9)
EPA Substance Registry System
o-Nitrobenzoic acid (552-16-9)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-68-22
Safety Statements 
26-36/37/39
WGK Germany 
3
RTECS 
DH5050000
TSCA 
Yes
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
127698
Product name
2-Nitrobenzoic acid
Purity
95%, Contains 3- and 4-isomers
Packaging
5g
Price
$52.7
Updated
2025/07/31
Sigma-Aldrich
Product number
127698
Product name
2-Nitrobenzoic acid
Purity
95%, Contains 3- and 4-isomers
Packaging
100g
Price
$160
Updated
2025/07/31
TCI Chemical
Product number
N0155
Product name
2-Nitrobenzoic Acid
Purity
>90.0%(GC)
Packaging
25g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
N0155
Product name
2-Nitrobenzoic Acid
Purity
>90.0%(GC)
Packaging
500g
Price
$460
Updated
2025/07/31
TRC
Product number
N493515
Product name
2-Nitrobenzoic acid
Packaging
10g
Price
$60
Updated
2021/12/16
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2-Nitrobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

NH2-protecting reagent.

Uses

2-Nitrobenzoic Acid is used as a reagent in the synthesis of several organic compounds including that of novel triazoles and a tetrazole of escitalopram which act as cholinesterase inhibitors. It is also used in the one pot synthesis of 1,4-disubstituted 1,2,3-triazoles.

Definition

ChEBI: A nitrobenzoic acid carrying the nitro substituent at position 2.

Synthesis Reference(s)

The Journal of Organic Chemistry, 56, p. 5924, 1991 DOI: 10.1021/jo00020a040
Tetrahedron Letters, 35, p. 219, 1994 DOI: 10.1016/S0040-4039(00)76515-4

General Description

Yellowish white crystals with an intensely sweet taste.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Nitrobenzoic acid is incompatible with strong oxidizing agents. Also incompatible with strong bases. May react with cyanides .

Health Hazard

ACUTE/CHRONIC HAZARDS: When 2-Nitrobenzoic acid is heated to decomposition it emits very toxic fumes.

Fire Hazard

Flash point data concerning 2-Nitrobenzoic acid are not available, however, 2-Nitrobenzoic acid is probably combustible.

Purification Methods

Crystallise the acid from *benzene (twice), n-butyl ether (twice), then water (twice). Dry and store it in a vacuum desiccator. [Le Noble & Wheland J Am Chem Soc 80 5397 1958.] It has also been crystallised from EtOH/H2O. The amide has m 176.5o (from H2O). [Beilstein 9 III 1466, 9 IV 1046.]

2-Nitrobenzoic acid Preparation Products And Raw materials

Raw materials

2-Nitrotoluene

Preparation Products

Methyl anthranilate 2-Nitrobenzoyl chloride Fomesafen
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View Lastest Price from 2-Nitrobenzoic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Nitrobenzoic acid 552-16-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-16
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Nitrobenzoic acid 552-16-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2025-03-14
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Nitrobenzoic acid 552-16-9
Price
US $30.00-10.00/kg
Min. Order
10kg
Purity
99%
Supply Ability
100000kg
Release date
2024-08-20

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