Methyl chloroacetate

Product Name: Methyl chloroacetate
CAS No.: 96-34-4
Chemical Name: Methyl chloroacetate
Synonyms: methyl 2-chloroacetate;MONO METHYL CHLORO ACETATE;METHYL MONOCHLOROACETATE;IHT-FC MCA;Chloroacetic acid methyl;CHLOROACETIC ACID METHYL ESTER;ClH2CCOOCH3;AKOS BBS-00004061;Methylechloroacetate;Mathyl Chloroacetate
CBNumber: CB9854725
Molecular Formula: C3H5ClO2
Formula Weight: 108.52
MOL File: 96-34-4.mol

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Methyl chloroacetate Property

Melting point:: -33 °C
Boiling point:: 130 °C740 mm Hg(lit.)
Density: 1.238 g/mL at 25 °C(lit.)
vapor density: 3.8 (vs air)
vapor pressure: 10 mm Hg ( 25 °C)
refractive index: n20/D 1.422(lit.)
Flash point:: 125 °F
storage temp.: Store at <= 20°C.
solubility: 51.6g/l (slow decomposition)
form: Liquid
color: Clear colorless
PH: 4.6 (28g/l, H2O, 20℃)
explosive limit: 4.6-18.5%(V)
Water Solubility: 28 g/L (20 ºC)
Merck: 14,6042
BRN: 506255
Dielectric constant: 12.9（20℃）
LogP: 0.63 at 20℃
CAS DataBase Reference: 96-34-4(CAS DataBase Reference)
NIST Chemistry Reference: Acetic acid, chloro-, methyl ester(96-34-4)
EPA Substance Registry System: Acetic acid, 2-chloro-, methyl ester (96-34-4)

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Safety

Hazard Codes: T,Xi,F
Risk Statements: 10-23/25-37/38-41-40-36/37/38-38
Safety Statements: 26-37/39-45-36-16
RIDADR: UN 2295 6.1/PG 1
WGK Germany: 2
RTECS: AF9500000
F: 19
Autoignition Temperature: 869 °F
TSCA: Yes
HS Code: 2915 40 00
HazardClass: 6.1
PackingGroup: I
Hazardous Substances Data: 96-34-4(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: 107 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.02413
Product name: Methyl chloroacetate
Purity: for synthesis
Packaging: 100mL
Price: $39
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02413
Product name: Methyl chloroacetate
Purity: for synthesis
Packaging: 1L
Price: $84.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 108413
Product name: Methyl chloroacetate
Purity: 99%
Packaging: 500g
Price: $60.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 108413
Product name: Methyl chloroacetate
Purity: 99%
Packaging: 1kg
Price: $63
Updated: 2024/03/01

Alfa Aesar

Product number: A10325
Product name: Methyl chloroacetate, 99+%
Packaging: 250g
Price: $20.6
Updated: 2024/03/01

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Methyl chloroacetate Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid with a slight irritating odor. It is miscible with organic solvents such as ethanol, ether, acetone and benzene. Slightly soluble in water.

Uses

Methyl chloroacetate is used as a solvent and chemical intermediate. It acts as a precursor in the preparation of (carboxymethyl) trimethylammonium chloride esters. Further, it is used in the preparation of octakis-(carbethoxymethoxy)calix[8]arene. It is employed as an extraction solvent during the separation of neutral compounds. In addition to this, it is used in the synthesis of dimethyl carbonate.

Application

Methyl chloroacetate (MC) is a halogenated ester mainly used as a solvent in organic synthesis or in the preparation of several compounds. Typically, MC is used in the preparation of (carboxymethyl) trimethylammonium chloride estersor in the synthesis of octakis- (carbethoxymethoxy)calix[8]arene. Additionally, methyl chloroacetate acts as an extraction solvent during the separation of neutral compounds with concentration enhancement using coupling liquid–liquid semi-microextraction with micellar electrokinetic chromatography through oncapillary decomposition.

Preparation

Methyl chloroacetate is prepared by esterification of chloroacetic acid with methanol.
Reaction: Methanol and chloroacetic acid are uniformly mixed in a weight ratio of 0.366:1, heated with stirring, and the esterification reaction is carried out at 105-110 °C. In the reaction process, the ternary azeotrope of methyl chloroacetate, water and methanol is continuously steamed, layered through the ester separator, the separated methanol and water are returned to the reaction pot, and the separated crude ester is made of sodium carbonate. neutralize. The neutralized crude ester is firstly cut out the 130°C fraction by atmospheric distillation, and then subjected to vacuum distillation to collect the 65°C (8kPa) fraction, which is the finished product of methyl chloroacetate. The yield is about 96%.

Synthesis Reference(s)

The Journal of Organic Chemistry, 50, p. 3408, 1985 DOI: 10.1021/jo00218a034

General Description

A crystalline solid or a solid dissolved in a liquid. Insoluble in water and denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Methyl chloroacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Toxic by ingestion and inhalation.

Health Hazard

Extremely corrosive to the eyes, skin, nose, throat, and upper respiratory tract. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Fire Hazard

Special Hazards of Combustion Products: Toxic fumes of hydrogen chloride

Safety Profile

Poison by ingestion. Moderately toxic by inhalation and subcutaneous routes. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Cl-.

Purification Methods

Shake the ester with saturated aqueous Na2CO3 (three times), aqueous 50% CaCl2 (three times), saturated aqueous NaCl (twice), dry (Na2SO4) and fractionally distil it. Very toxic. [Beilstein 2 IV 480.]

Methyl chloroacetate Preparation Products And Raw materials

Raw materials

Chloroacetic acid Potassium fluoride Chlorine PHOSGENE Acetic acid Methanol

Preparation Products

3-Cyanomethylthiophene Dimethoate Thiophene-3-ethanol METHYL 3-METHYL-2-FUROATE 3-Thiopheneacetic acid 1,2-DIHYDRO-4-(METHOXYMETHYL)-6-METHYL-5-NITRO-2-OXONICOTINONITRILE Piracetam (4,6-DIMETHYL-PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE NOCODAZOLE QUINTIOPHOS O,O-DIMETHYL-S-(METHOXY-CARBONYL) THIOPHOSPHATE CHLOROMETHYLACETAMIDE Glycinamide hydrochloride THIOPHEN-3-YL-ACETYL CHLORIDE 2-METHOXYPHENOXYACETIC ACID Omethoate METHYL 3-(6-METHOXY-2-NAPHTHYL)-3-METHYL GLYCIDATE 2-HYDROXYPYRAZINE 2-PIPERAZIN-1-YL-ACETAMIDEHYDROCHLORIDE 3-Methyl-2-furoic acid 2-Bromo-5-fomylthiazole Methyl methoxyacetate Methyl [(dimethoxyphosphinothioyl)thio]acetate Methyl fluoroacetate Methyl cyanoacetate

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Methyl chloroacetate Suppliers

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View Lastest Price from Methyl chloroacetate manufacturers

Ningxia Jinhua Chemical Co.,Ltd

Product: Methyl chloroacetate 96-34-4
Price: US $0.00/Kg/Drum
Min. Order: 1000KG
Purity: 99%
Supply Ability: 10tons
Release date: 2020-12-17

Gansu Jinyuantai New Material Co., Ltd.

Product: Methyl chloroacetate 96-34-4
Price: US $0.00/Kg/Drum
Min. Order: 1000KG
Purity: 99%
Supply Ability: 10tons
Release date: 2020-12-17

Changde Changlian Chemical Co., Ltd.

Product: Methyl chloroacetate 96-34-4
Price: US $0.00/Kg/Drum
Min. Order: 1000KG
Purity: 99%
Supply Ability: 10tons
Release date: 2020-12-17

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ClCH2COOCH3

Organic Building Blocks

Esters

C2 to C5

Carbonyl Compounds

Building Blocks

Pyridines ,Halogenated Heterocycles