Amphomycin
- Product Name
- Amphomycin
- CAS No.
- 1402-82-0
- Chemical Name
- Amphomycin
- Synonyms
- Nsc267431;Amphomycin
- CBNumber
- CB9938498
- Molecular Formula
- C58H91N13O20
- Formula Weight
- 1290.43
- MOL File
- 1402-82-0.mol
Amphomycin Property
- alpha
- D25 +7.5° (c = 1 at pH 6)
- Boiling point:
- 854.06°C (rough estimate)
- Density
- 1.0985 (rough estimate)
- refractive index
- 1.6700 (estimate)
- color
- Crystals
Safety
- Toxicity
- LD50 orl-mus: 500 mg/kg 85GDA2 4(1),317,80
N-Bromosuccinimide Price
- Product number
- 17091
- Product name
- Amphomycin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $259
- Updated
- 2021/03/22
- Product number
- 17091
- Product name
- Amphomycin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $907
- Updated
- 2021/03/22
Amphomycin Chemical Properties,Usage,Production
Originator
Amphocortrin CR,Warner Lambert,US,1963
Uses
Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed until 2000. Amphomycin is active against Gram positive bacteria, inhibiting peptidoglycan synthesis and blocking cell wall development. Amphomycin is closely related to a number of “lost” antibiotics, aspartocin, crystallomycin, glumamycin, friulimicin, laspartocin, tsushimycin and zaomycin. Interest in amphomycin was re-awakened with the discovery of friulimicin activity against antibiotic resistant strains.
Manufacturing Process
The process for producing amphomycin comprises cultivating a strain of
Streptomyces canus in an aqueous, nutrient-containing carbohydrate solution
under submerged aerobic conditions until substantial antibacterial activity is
imparted to the solution and then recovering the so-produced amphomycin
from the fermentation broth.
The process of decolorizing solutions of amphomycin then involves treatment
with activated charcoal, followed by the steps of (1) extracting the antibiotic
into a water-immiscible organic solvent under strongly acid conditions or
precipitating the amphomycin from aqueous solution by adjusting the pH to a
point within the range of pH 3.0 to 4.0, (2) removing impurities from strongly
acid, aqueous solution of amphomycin by extraction of the impurities with
methyl isobutyl ketone and amyl acetate, (3) extracting the amphomycin from
a strongly acid solution in butanol by the use of water having a pH higher
than 4, (4) extracting the amphomycin from solution in water-immiscible
organic solvent into water whose pH is greater than 6.0, (5) precipitating
amphomycin from solution by formation of insoluble derivatives of the basic
function, and (6) precipitating amphomycin from solution by formation of
insoluble derivates of the acidic function.
The amphomycin is then converted to the calcium salt with calcium hydroxide.
Therapeutic Function
Antibiotic
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Induces hemolysis. Active against gram-positive bacteria.Suggested as a topical agent for animal and plantinfections. When heated to decomposition it emits acridsmoke and
Amphomycin Preparation Products And Raw materials
Raw materials
Preparation Products
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