Amphomycin

Product Name
Amphomycin
CAS No.
1402-82-0
Chemical Name
Amphomycin
Synonyms
Nsc267431;Amphomycin
CBNumber
CB9938498
Molecular Formula
C58H91N13O20
Formula Weight
1290.43
MOL File
1402-82-0.mol
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Amphomycin Property

alpha 
D25 +7.5° (c = 1 at pH 6)
Boiling point:
854.06°C (rough estimate)
Density 
1.0985 (rough estimate)
refractive index 
1.6700 (estimate)
color 
Crystals
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Safety

Toxicity
LD50 orl-mus: 500 mg/kg 85GDA2 4(1),317,80
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17091
Product name
Amphomycin
Purity
≥95%
Packaging
1mg
Price
$249
Updated
2020/06/24
Cayman Chemical
Product number
17091
Product name
Amphomycin
Purity
≥95%
Packaging
5mg
Price
$872
Updated
2020/06/24
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Amphomycin Chemical Properties,Usage,Production

Originator

Amphocortrin CR,Warner Lambert,US,1963

Uses

Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed until 2000. Amphomycin is active against Gram positive bacteria, inhibiting peptidoglycan synthesis and blocking cell wall development. Amphomycin is closely related to a number of “lost” antibiotics, aspartocin, crystallomycin, glumamycin, friulimicin, laspartocin, tsushimycin and zaomycin. Interest in amphomycin was re-awakened with the discovery of friulimicin activity against antibiotic resistant strains.

Manufacturing Process

The process for producing amphomycin comprises cultivating a strain of Streptomyces canus in an aqueous, nutrient-containing carbohydrate solution under submerged aerobic conditions until substantial antibacterial activity is imparted to the solution and then recovering the so-produced amphomycin from the fermentation broth.
The process of decolorizing solutions of amphomycin then involves treatment with activated charcoal, followed by the steps of (1) extracting the antibiotic into a water-immiscible organic solvent under strongly acid conditions or precipitating the amphomycin from aqueous solution by adjusting the pH to a point within the range of pH 3.0 to 4.0, (2) removing impurities from strongly acid, aqueous solution of amphomycin by extraction of the impurities with methyl isobutyl ketone and amyl acetate, (3) extracting the amphomycin from a strongly acid solution in butanol by the use of water having a pH higher than 4, (4) extracting the amphomycin from solution in water-immiscible organic solvent into water whose pH is greater than 6.0, (5) precipitating amphomycin from solution by formation of insoluble derivatives of the basic function, and (6) precipitating amphomycin from solution by formation of insoluble derivates of the acidic function.
The amphomycin is then converted to the calcium salt with calcium hydroxide.

Therapeutic Function

Antibiotic

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Induces hemolysis. Active against gram-positive bacteria.Suggested as a topical agent for animal and plantinfections. When heated to decomposition it emits acridsmoke and

Amphomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Amphomycin Suppliers

ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
19252
Advantage
56
Novachemistry
Tel
+44 (0)208 191 7890
Fax
+44 (0)203 637 6965
Email
info@novachemistry.com
Country
United Kingdom
ProdList
3795
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
400-002-6226
Email
sales@biochemall.cn
Country
China
ProdList
54467
Advantage
58
Career Henan Chemica Co
Tel
0371-86658258
Fax
0371-86658258
Email
Laboratory@coreychem.com
Country
CHINA
ProdList
30312
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11411
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8859
Advantage
58
MedBio?Pharmaceutical Technology Inc
Tel
021-69568360-
Email
order@med-bio.cn
Country
China
ProdList
8195
Advantage
58