ChemicalBook > CAS DataBase List > 3'-Bromo-2'-Fluoroacetophenone

3'-Bromo-2'-Fluoroacetophenone

Product Name: 3'-Bromo-2'-Fluoroacetophenone
CAS No.: 161957-61-5
Chemical Name: 3'-Bromo-2'-Fluoroacetophenone
Synonyms: 1-(3-Bromo-2-fluorophenyl)ethan-1-one;153471;1-(3-Bromo-2-fL;3-Bromo-2-fluorobenzophenone;3-bormo-2-fluoroacetophenone;3'-Bromo-2'-fluoroacetophenone;3'-Bromo-2'-fluoroacetophenone;3-Bromo-2-fluoroacetophenone,96%;3'-Bromo-2'-fluoroacetophenone 95%;1-(3-Bromo-2-fluoro-phenyl)-ethanone
CBNumber: CB9950175
Molecular Formula: C8H6BrFO
Formula Weight: 217.04
MOL File: 161957-61-5.mol

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3'-Bromo-2'-Fluoroacetophenone Property

Boiling point:: 252.4±25.0 °C(Predicted)
Density: 1.535±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: Solid
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C8H6BrFO/c1-5(11)6-3-2-4-7(9)8(6)10/h2-4H,1H3
InChIKey: GSLFYQYBXIVNLS-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=CC(Br)=C1F)C

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Safety

HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B693003
Product name: 1-(3-Bromo-2-fluorophenyl)ethanone
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 074064
Product name: 1-(3-Bromo-2-fluorophenyl)ethanone
Purity: 95+%
Packaging: 25g
Price: $476
Updated: 2021/12/16

AK Scientific

Product number: X4555
Product name: 3'-Bromo-2'-fluoroacetophenone
Packaging: 250mg
Price: $74
Updated: 2021/12/16

AK Scientific

Product number: X4555
Product name: 3'-Bromo-2'-fluoroacetophenone
Packaging: 1g
Price: $85
Updated: 2021/12/16

Apolloscientific

Product number: PC48297
Product name: 3'-Bromo-2'-fluoroacetophenone
Purity: 97%
Packaging: 1g
Price: $34
Updated: 2021/12/16

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3'-Bromo-2'-Fluoroacetophenone Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 881, 1995 DOI: 10.1016/0040-4039(94)02385-O

Synthesis

680610-73-5

75-16-1

161957-61-5

General procedure for the synthesis of 3-bromo-2-fluoroacetophenone from N-methoxy-N-methyl-3-bromo-2-fluorobenzamide and methylmagnesium bromide: 1. methylmagnesium bromide (3M in ether, 21mL) was slowly added to a solution of tetrahydrofuran (100mL) containing 3-bromo-2-fluoro-N-methoxy-N-methylbenzamide (10.89g) at -78°C. 2. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. 3. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched by slow addition of 2 M HCl solution up to pH=1 . 4. The solvent was removed by rotary evaporator and the product was subsequently extracted with ethyl acetate (3 x 100 mL). 5. The organic layers were combined, dried over anhydrous sodium sulfate and the solvent was again removed by rotary evaporator to give a light brown solid product. 6. The resulting solid was dissolved in dichloromethane (200 mL) and washed with saturated aqueous NaHCO3 (200 mL). 7. The dichloromethane layer was separated, dried with anhydrous sodium sulfate, and finally the solvent was removed by rotary evaporator to give 1-(3-bromo-2-fluorophenyl)-acetophenone as a yellow oil (8.8 g, 97% yield). 1H NMR (CDCl3) data: δ 2.67 (3H, d, ArCOCH3), 7.11 (1H, t, Ar), 7.69-7.81 (2H, m, Ar).

References

[1] Patent: US2009/209529, 2009, A1. Location in patent: Page/Page column 34
[2] Patent: US2008/76771, 2008, A1. Location in patent: Page/Page column 18

3'-Bromo-2'-Fluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3'-Bromo-2'-Fluoroacetophenone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3'-Bromo-2'-Fluoroacetophenone 161957-61-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Career Henan Chemical Co

Product: 3'-Bromo-2'-Fluoroacetophenone 161957-61-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-20

161957-61-5, 3'-Bromo-2'-FluoroacetophenoneRelated Search:

1-(4-Bromo-2-fluorophenyl)ethanone 2'-Fluoroacetophenone 2'-Bromo-4'-fluoroacetophenone 97%,2'-Bromo-4'-fluoroacetophenone97% 2-Bromo-4'-fluoroacetophenone 2'-BROMO-5'-FLUOROACETOPHENONE 2-BROMO-2'-FLUOROACETOPHENONE ALPHA-BROMO-3-FLUOROACETOPHENONE,2-BROMO-3'-FLUOROACETOPHENONE 3'-Bromo-4'-fluoroacetophenone97%,3- BROMO-4-FLUOROACETOPHENONE 98+%,3'-BROMO-4'-FLUOROACETOPHENONE,3-BROMO-4-FLUOROACETOPHENONE BUTTPARK 87\07-41 3'-Bromo-2'-Fluoroacetophenone

1-(3-Bromo-2-fluoro-phenyl)-ethanone

3-Bromo-2-fluorobenzophenone

1-(3-Bromo-2-fluorophenyl)ethan-1-one

3'-Bromo-2'-fluoroacetophenone 95%

153471

1-(3-Bromo-2-fL

Ethanone, 1-(3-bromo-2-fluorophenyl)-

3-Bromo-2-fluoroacetophenone,96%

3-bormo-2-fluoroacetophenone

3'-Bromo-2'-fluoroacetophenone

161957-61-5

Adehydes, Acetals & Ketones

Bromine Compounds

Fluorine Compounds