3'-Bromo-2'-Fluoroacetophenone
- Product Name
- 3'-Bromo-2'-Fluoroacetophenone
- CAS No.
- 161957-61-5
- Chemical Name
- 3'-Bromo-2'-Fluoroacetophenone
- Synonyms
- 1-(3-Bromo-2-fluorophenyl)ethan-1-one;153471;1-(3-Bromo-2-fL;3-Bromo-2-fluorobenzophenone;3-bormo-2-fluoroacetophenone;3'-Bromo-2'-fluoroacetophenone;3'-Bromo-2'-fluoroacetophenone;3-Bromo-2-fluoroacetophenone,96%;3'-Bromo-2'-fluoroacetophenone 95%;1-(3-Bromo-2-fluoro-phenyl)-ethanone
- CBNumber
- CB9950175
- Molecular Formula
- C8H6BrFO
- Formula Weight
- 217.04
- MOL File
- 161957-61-5.mol
3'-Bromo-2'-Fluoroacetophenone Property
- Boiling point:
- 252.4±25.0 °C(Predicted)
- Density
- 1.535±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Solid
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C8H6BrFO/c1-5(11)6-3-2-4-7(9)8(6)10/h2-4H,1H3
- InChIKey
- GSLFYQYBXIVNLS-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=CC(Br)=C1F)C
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B693003
- Product name
- 1-(3-Bromo-2-fluorophenyl)ethanone
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC48297
- Product name
- 3'-Bromo-2'-fluoroacetophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- 2617-B-X7
- Product name
- 2'-Fluoro-3'-bromoacetophenone
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
- Product number
- 074064
- Product name
- 1-(3-Bromo-2-fluorophenyl)ethanone
- Purity
- 95+%
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- X4555
- Product name
- 3'-Bromo-2'-fluoroacetophenone
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
3'-Bromo-2'-Fluoroacetophenone Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 881, 1995 DOI: 10.1016/0040-4039(94)02385-O
Synthesis
680610-73-5
75-16-1
161957-61-5
General procedure for the synthesis of 3-bromo-2-fluoroacetophenone from N-methoxy-N-methyl-3-bromo-2-fluorobenzamide and methylmagnesium bromide: 1. methylmagnesium bromide (3M in ether, 21mL) was slowly added to a solution of tetrahydrofuran (100mL) containing 3-bromo-2-fluoro-N-methoxy-N-methylbenzamide (10.89g) at -78°C. 2. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. 3. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched by slow addition of 2 M HCl solution up to pH=1 . 4. The solvent was removed by rotary evaporator and the product was subsequently extracted with ethyl acetate (3 x 100 mL). 5. The organic layers were combined, dried over anhydrous sodium sulfate and the solvent was again removed by rotary evaporator to give a light brown solid product. 6. The resulting solid was dissolved in dichloromethane (200 mL) and washed with saturated aqueous NaHCO3 (200 mL). 7. The dichloromethane layer was separated, dried with anhydrous sodium sulfate, and finally the solvent was removed by rotary evaporator to give 1-(3-bromo-2-fluorophenyl)-acetophenone as a yellow oil (8.8 g, 97% yield). 1H NMR (CDCl3) data: δ 2.67 (3H, d, ArCOCH3), 7.11 (1H, t, Ar), 7.69-7.81 (2H, m, Ar).
References
[1] Patent: US2009/209529, 2009, A1. Location in patent: Page/Page column 34
[2] Patent: US2008/76771, 2008, A1. Location in patent: Page/Page column 18
3'-Bromo-2'-Fluoroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
3'-Bromo-2'-Fluoroacetophenone Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 3'-Bromo-2'-Fluoroacetophenone manufacturers
- Product
- 3'-Bromo-2'-Fluoroacetophenone 161957-61-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-12
- Product
- 3'-Bromo-2'-Fluoroacetophenone 161957-61-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20