Aliskiren

ChemicalBook > CAS DataBase List > Aliskiren

Product Name: Aliskiren
CAS No.: 173334-57-1
Chemical Name: Aliskiren
Synonyms: CS-201;SPP 100;Rasilez;Tekturna;CGP60536B;CGP 60536;Aliskiren;Aliskiren Base;Aliskiren (USAN);Aliskiren, >=98%
CBNumber: CB9966226
Molecular Formula: C30H53N3O6
Formula Weight: 551.76
MOL File: 173334-57-1.mol

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Aliskiren Property

Melting point:: 98-99 °C
Boiling point:: 748.4±60.0 °C(Predicted)
Density: 1.067±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO : 100 mg/mL (181.24 mM; Need ultrasonic)
form: Powder
pka: 9.49(at 25℃)
CAS DataBase Reference: 173334-57-1(CAS DataBase Reference)

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Safety

Hazardous Substances Data: 173334-57-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS023114
Product name: Aliskiren
Packaging: 10MG
Price: $209
Updated: 2024/03/01

ChemScene

Product number: CS-0443
Product name: Aliskiren
Purity: 99.16%
Packaging: 50mg
Price: $240
Updated: 2021/12/16

ApexBio Technology

Product number: A3153
Product name: Aliskiren
Packaging: 1g
Price: $314
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA134549
Product name: 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
Packaging: 2g
Price: $350
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611736
Product name: Aliskiren
Packaging: 10mg
Price: $460.7
Updated: 2021/12/16

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Aliskiren Chemical Properties,Usage,Production

Description

Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .

Originator

Novartis (Switzerland)

Uses

An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive

Uses

liquid crystal intermediate

Definition

ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.

brand name

Tekturna

General Description

Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.

Aliskiren Preparation Products And Raw materials

Raw materials

Preparation Products

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Aliskiren Suppliers

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View Lastest Price from Aliskiren manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Aliskiren 173334-57-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-04-16

Hebei Duling International Trade Co. LTD

Product: Aliskiren 173334-57-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2023-04-19

Henan Bao Enluo International TradeCo.，LTD

Product: Aliskiren 173334-57-1
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-02

173334-57-1, AliskirenRelated Search:

Tris(hydroxymethyl)aminomethane Glycine Isopropyl alcohol 6-Aminocaproic acid POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 4-Methoxybenzyl cyanide ISOPROPYL LAURATE p-Anisidine 4-Methoxyphenol p-Anisaldehyde CHLOROPHOSPHONAZO III Guaiacol ALTRENOGEST Anisole (Trifluoromethoxy)benzene Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- Aliskiren hemifumarate Aliskiren inter-8

Aliskiren

(aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide

CGP 60536

CGP60536B

Rasilez

SPP 100

Tekturna

(aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide

(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide

ALISKIREN FREE BASE

(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-Methoxybenzyl)-5-aMino-N-(2-carbaMoyl-2-Methylpropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide

Aliskiren (CGP 60536)

Aliskiren (USAN)

CGP 60536;CGP60536B;SPP 100

CS-201

CGP-60536; CGP60536; TEKTURNA;SPP 100

(2S,4S,5S,7S)-7-(4-Methoxy-3-(3-Methoxypropoxy)benzyl)-5-aMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide

Aliskiren Base

5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate

Aliskiren, >=98%

5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypr

Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-

Aliskiren USP/EP/BP

(2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Aliskiren 99% CAS NO.173334-57-1

173334-57-1

C30H53N3O6HCl

C30H53N3O6

C34H57N3O10

C30H53N3O6C4H4O4

API

Amines

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals

Chemical Amines

Aliskiren intermediates