ChemicalBook > CAS DataBase List > Aliskiren

Aliskiren

Product Name
Aliskiren
CAS No.
173334-57-1
Chemical Name
Aliskiren
Synonyms
CS-201;SPP 100;Rasilez;Tekturna;CGP60536B;CGP 60536;Aliskiren;Aliskiren Base;Aliskiren (USAN);Aliskiren, >=98%
CBNumber
CB9966226
Molecular Formula
C30H53N3O6
Formula Weight
551.76
MOL File
173334-57-1.mol
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Aliskiren Property

Melting point:
98-99 °C
Boiling point:
748.4±60.0 °C(Predicted)
Density 
1.067±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO : 100 mg/mL (181.24 mM; Need ultrasonic)
form 
Powder
pka
9.49(at 25℃)
color 
White to light yellow
InChIKey
UXOWGYHJODZGMF-PPPRLRNRNA-N
SMILES
C(C)(C)(CNC(=O)[C@H](C(C)C)C[C@H](O)[C@@H](N)C[C@@H](C(C)C)CC1C=CC(OC)=C(OCCCOC)C=1)C(N)=O |&1:7,12,14,17,r|
CAS DataBase Reference
173334-57-1(CAS DataBase Reference)
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Safety

Hazardous Substances Data
173334-57-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS023114
Product name
Aliskiren
Packaging
10MG
Price
$216
Updated
2025/07/31
Biosynth Carbosynth
Product number
FA134549
Product name
5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
Packaging
250mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0443
Product name
Aliskiren
Purity
99.16%
Packaging
5mg
Price
$84
Updated
2021/12/16
Matrix Scientific
Product number
158321
Product name
5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
Packaging
0.500g
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0443
Product name
Aliskiren
Purity
99.16%
Packaging
10mg
Price
$132
Updated
2021/12/16
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Aliskiren Chemical Properties,Usage,Production

Description

Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .

Originator

Novartis (Switzerland)

Uses

An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive

Uses

liquid crystal intermediate

Definition

ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.

brand name

Tekturna

General Description

Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.

Aliskiren Preparation Products And Raw materials

Raw materials

Preparation Products

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Aliskiren Suppliers

Canada 1 China 171 India 9 United Kingdom 2 United States 19 Global 202
ArkGen Pharma Private Limited
Tel
--
Fax
--
Country
India
ProdList
20
Advantage
58
Arkgen Farma
Tel
--
Fax
--
Country
India
ProdList
2
Advantage
58
Chiral Biosciences Limited
Tel
--
Fax
--
Country
India
ProdList
41
Advantage
58
Splendid Lab
Tel
--
Fax
--
Country
India
ProdList
5
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
Manus Aktteva
Tel
--
Fax
--
Email
info@manusaktteva.in
Country
India
ProdList
581
Advantage
34
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View Lastest Price from Aliskiren manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Aliskiren 173334-57-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Aliskiren 173334-57-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-16
Apeloa production Co.,Limited
Product
Aliskiren 173334-57-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000
Release date
2024-06-19

173334-57-1, AliskirenRelated Search:

Glycine Isopropyl alcohol 6-Aminocaproic acid POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 4-Methoxybenzyl cyanide ISOPROPYL LAURATE p-Anisidine 4-Methoxyphenol p-Anisaldehyde CHLOROPHOSPHONAZO III Guaiacol ALTRENOGEST Anisole (Trifluoromethoxy)benzene Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- Tris(hydroxymethyl)aminomethane Aliskiren hemifumarate Aliskiren inter-8

  • Aliskiren
  • (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide
  • CGP 60536
  • CGP60536B
  • Rasilez
  • SPP 100
  • Tekturna
  • (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide
  • (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide
  • ALISKIREN FREE BASE
  • (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-Methoxybenzyl)-5-aMino-N-(2-carbaMoyl-2-Methylpropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide
  • Aliskiren (CGP 60536)
  • Aliskiren (USAN)
  • CGP 60536;CGP60536B;SPP 100
  • CS-201
  • CGP-60536; CGP60536; TEKTURNA;SPP 100
  • (2S,4S,5S,7S)-7-(4-Methoxy-3-(3-Methoxypropoxy)benzyl)-5-aMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide
  • Aliskiren Base
  • 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
  • Aliskiren, >=98%
  • 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypr
  • Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-
  • Aliskiren USP/EP/BP
  • (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide
  • Aliskiren 99% CAS NO.173334-57-1
  • Aliskiren 100 μg/ml Acetonitrile
  • 173334-57-1
  • C30H53N3O6HCl
  • C30H53N3O6
  • C34H57N3O10
  • C30H53N3O6C4H4O4
  • API
  • Amines
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chemical Amines
  • Aliskiren intermediates