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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure:
Chemical Name:
4(1H)-Pyridinone, 2-(hydroxymethyl)-3,5-dimethyl- (9CI)
CAS:
220757-73-3
MF:
C8H11NO2
Chemical Name:
Rocuronium Bromide Impurity 19 、21、22
Chemical Name:
Flucloxacillin impurity D
Chemical Name:
Ritonavir EP Impurity STU
Chemical Name:
Letermovir Impurity 1
Chemical Name:
Roxadustat Impurity 16
Chemical Name:
Perospirone Impurity 19
Chemical Name:
Dolutegravir Impurity 14(Sodium Salt)
Chemical Name:
Fondaparinux sodium impurity 5
Chemical Name:
Fondaparinux sodium impurity 20
Chemical Name:
Piperacillin Impurity R
Structure:
Chemical Name:
Desacetylvinblastine hydrazide
CAS:
55383-37-4
MF:
C43H56N6O7
Structure:
Chemical Name:
glycopyrronium bromide
CAS:
475468-09-8
MF:
C19H28NO3.Br
Structure:
Chemical Name:
4'-hydroxyflurbiprofen
CAS:
52807-12-2
MF:
C15H13FO3
Structure:
Chemical Name:
D-biotin-d-sulfoxide
CAS:
10406-89-0
MF:
C10H16N2O4S
Structure:
Chemical Name:
3,4-dihydroxyphenylpyruvic acid
CAS:
4228-66-4
MF:
C9H8O5
Chemical Name:
Imimidistine impurity E
Structure:
Chemical Name:
delta(3)-cefotiam
CAS:
142182-63-6
MF:
C18H23N9O4S3
Chemical Name:
AMOXICILLIN TRIHYDRATE IMP. E (EP): (2RS,4S)-2-[[[(2R)-2-AMINO-2-(4-HYDROXYPHENYL)ACETYL]AMINO]METHYL]-5,5-DIMETHYLTHIAZOLIDINE-4-CARBOXYLIC ACID (PENILLOIC ACIDS OF AMOXICILLIN)
Structure:
Chemical Name:
4-CHLORO-7-(2-CHLORO-ETHOXY)-6-(2-METHOXY-ETHOXY)-QUINAZOLINE
CAS:
183322-20-5
MF:
C13H14Cl2N2O3
Structure:
Chemical Name:
METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE
CAS:
39562-27-1
MF:
C12H11NO5
Chemical Name:
Sugammadex sodium Impurity 48
Chemical Name:
Sugammadex sodium Impurity 47
Structure:
Chemical Name:
Tenofovir Impurity 95
CAS:
1884329-63-8
MF:
C8H10BrN5
Structure:
Chemical Name:
Tenofovir Impurity 117
CAS:
1643116-22-6
MF:
C8H11N5O
Chemical Name:
Tafluprost Impurity E
Chemical Name:
Cabozantinib impurity 36
Structure:
Chemical Name:
Apigenin 7-O-(2'',6''-di-O-E-p-coumaroyl)glucoside
CAS:
1448779-19-8
MF:
C39H32O14
Chemical Name:
Dapoxetine impurity 69
Structure:
Chemical Name:
4-FLUORO-2-METHYLBENZAMIDE
CAS:
886501-45-7
MF:
C8H8FNO
Structure:
Chemical Name:
1-{[4-BENZYL-2-(3,4-DIMETHOXYPHENYL)-4H-CHROMEN-3-YL]METHYL}PIPERIDINIUM CHLORIDE
MF:
C30H34ClNO3
Structure:
Chemical Name:
4-Hydroxyisophthalonitrile
CAS:
34133-58-9
MF:
C8H4N2O
Chemical Name:
Empagliflozin Impurity 81
Chemical Name:
Oseltamivir Impurity 126
Chemical Name:
Oseltamivir Impurity 126
Structure:
Chemical Name:
2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-hydroxyphenyl)-1,1-dimethylethyl]amino]ethyl]-, hydrochloride (1:1)
CAS:
936490-85-6
MF:
C20H25ClN2O5
Structure:
Chemical Name:
4-hydroxypyrrolidin-2-one
CAS:
96820-00-7
MF:
C4H7NO2
Structure:
Chemical Name:
anemonin
CAS:
508-44-1
MF:
C10H8O4
Structure:
Chemical Name:
alpha-(chloromethyl)-2-hydroxymethyl-5-nitroimidazole-1-ethanol
CAS:
62580-79-4
MF:
C7H10ClN3O4
Structure:
Chemical Name:
7-(deoxyadenosin-N(6)-yl)aristolactam I
CAS:
127191-86-0
MF:
C27H22N6O7
Structure:
Chemical Name:
4-hydroxypenicillin V
CAS:
20880-67-5
MF:
C16H18N2O6S
Structure:
Chemical Name:
BENAZEPRILAT
CAS:
86541-78-8
MF:
C22H24N2O5
Structure:
Chemical Name:
9-Methylene-9H-fluorene
CAS:
4425-82-5
MF:
C14H10
Structure:
Chemical Name:
2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
CAS:
38385-95-4
MF:
C12H15N3
Structure:
Chemical Name:
4-CHLORO-3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL
CAS:
142885-96-9
MF:
C8H9Cl2N
Structure:
Chemical Name:
9-DIHYDROESTRADIOL
CAS:
791-69-5
MF:
C18H22O2
Structure:
Chemical Name:
(2S,3S,5S)-5-[(N-Formyl-L-leucyl)oxy]-2-hexyl-3-hydroxyhexadecanoic Acid (Orlistat Impurity)
CAS:
130676-66-3
MF:
C29H55NO6
Structure:
Chemical Name:
(2S,3S,5S)-5-[(N-Formyl-L-leucyl)oxy]-2-hexyl-3-hydroxyhexadecanoic Acid (Orlistat Impurity)
CAS:
130676-66-3
MF:
C29H55NO6
Structure:
Chemical Name:
Pramipexole EP Impurity E
CAS:
106006-84-2
MF:
C10H15N3OS
Structure:
Chemical Name:
3-Morpholinone, 4-phenyl-
CAS:
29518-11-4
MF:
C10H11NO2
Structure:
Chemical Name:
H 128/80
CAS:
29122-74-5
MF:
C13H19NO3
Structure:
Chemical Name:
4’-Hydroxy Atomoxetine -D-Glucuronide
CAS:
540729-08-6
MF:
C23H29NO8
Structure:
Chemical Name:
Decarboxy Ciprofloxacin
CAS:
105394-83-0
MF:
C16H18FN3O
Structure:
Chemical Name:
Zolpidem 6-Carboxylic Acid
CAS:
109461-15-6
MF:
C19H19N3O3
Chemical Name:
Iohexol Impurity M
Chemical Name:
Relugolix Impurity 18
Chemical Name:
Rabeprazole Impurity 15
Structure:
Chemical Name:
4-((2-amino-2-oxoethyl)(hydroxy)amino)butanoic acid
CAS:
2454698-45-2
MF:
C6H12N2O4
Structure:
Chemical Name:
Lenvatinib Impurity LFZZ-8
MF:
C44H40Cl2N8O8
Chemical Name:
Pemetrexed disodium Impurity 19
Chemical Name:
Brivaracetam Impurity 32
Structure:
Chemical Name:
Apixaban Impurity 56
CAS:
2444918-46-9
MF:
C15H19N3O2
Chemical Name:
1-((2R,3R)-3-(4-(aminomethyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-((2-(methylamino)acetoxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium chloride
Chemical Name:
Ticagrelor Impurity 107
Structure:
Chemical Name:
2-Thiazolamine, 5-bromo-4-(5-bromo-4-chloro-2-thienyl)-
CAS:
2401867-89-6
MF:
C7H3Br2ClN2S2
Structure:
Chemical Name:
Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[2-[[4-(hydroxymethyl)benzoyl]methylamino]ethyl]-4-piperidinyl ester
CAS:
1682660-39-4
MF:
C29H33N3O4
Chemical Name:
sodium 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-3-hydroxypropanoate
Chemical Name:
(4S,6R)-((4R,6S)-6-(2-(tert-butoxy)-2-oxoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl 6-(2-(tert-butoxy)-2-oxoethyl)-2,2-dimethyl-1,3-dioxane-4-carboxylate
Chemical Name:
tert-butyl 2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-2-methyl-4- oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methyl propanoate
Structure:
Chemical Name:
Atomoxetine Impurity 15
CAS:
881995-45-5
MF:
C19H23NO2
Structure:
Chemical Name:
Pitavastatin Impurity 13 (Pitavastatin 2,4,6-Triene Impurity)
CAS:
2086271-67-0
MF:
C25H20FNO2
Chemical Name:
(2S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2- carboxylic acid sodium
Chemical Name:
impurity 39
Chemical Name:
(2R,3R,4R,5S)-6-((2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)phenyl)amino)hexane-1,2,3,4,5-pentaol
Chemical Name:
Bosutinib Impurity 32
Structure:
Chemical Name:
6,6'-Methylenebis[1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one
CAS:
1365727-09-8
MF:
C29H26N2O2
Structure:
Chemical Name:
Ampicillin Dimer Disodium Salt
CAS:
94730-51-5
MF:
C32H39N6NaO8S2
Structure:
Chemical Name:
4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, [5R-[3(S*),5α,6α(R*)]]- (9CI)
CAS:
106560-13-8
MF:
C12H15NO5S
Structure:
Chemical Name:
1-Naphthalenecarboxylic acid, 8-[[(3S)-1-azabicyclo[2.2.2]oct-3-ylamino]methyl]-5,6,7,8-tetrahydro-, (8S)-
CAS:
2407763-21-5
MF:
C19H26N2O2
Chemical Name:
Peramivir Impurity 58
Structure:
Chemical Name:
1-Naphthalenamine, 4-(2,3-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1R,4R)-rel-
CAS:
2124277-87-6
MF:
C17H17Cl2N
Chemical Name:
Voriconazole toxic impurity 2
Chemical Name:
Avatrombopag Impurity 31
Structure:
Chemical Name:
Cisatracurium besylate impurity19
CAS:
96946-52-0
MF:
C59H77N2O15S+
Chemical Name:
Bumetanide Impurity 3
Chemical Name:
Cefoxitin EP Impurity F (S-methoxy cefoxitin)
Chemical Name:
((((3R,6S)-6-carbamoylpiperidin-3-yl)(ethoxycarbonyl)amino)oxy)sulfonic acid
Structure:
Chemical Name:
INDEX NAME NOT YET ASSIGNED
CAS:
2514949-81-4
MF:
C20H28N4O2
Structure:
Chemical Name:
alpha-[4-[2-(dimethylamino)ethoxy]phenyl]-beta-ethyl-alpha-phenylphenethyl alcohol
CAS:
748-97-0
MF:
C26H31NO2
Chemical Name:
Brivaracetam Impurity 53
Structure:
Chemical Name:
ethyl hydrogen [R-(R*,R*)]-tartrate
CAS:
608-89-9
MF:
C6H10O6
Structure:
Chemical Name:
ethyl 2,2,4-trichloro-3-oxobutyrate
CAS:
85153-67-9
MF:
C6H7Cl3O3
Chemical Name:
Neodigoxin
CAS:
55576-67-5
MF:
C41H64O14
Chemical Name:
(S)-6-((R)-2-amino-2-phenylacetamido)-2,2-dimethyl-7-oxo-2,3,4,7-tetrahydro-1,4-thiazepine-3-carboxylic acid
Structure:
Chemical Name:
(R,R)-Palonosetron N-Oxide
MF:
C19H24N2O2
Structure:
Chemical Name:
[R(R*,R*]-2-amino-1-[p-(methylsulphonyl)phenyl]propane-1,3-diol
CAS:
51458-28-7
MF:
C10H15NO4S
Structure:
Chemical Name:
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
CAS:
77017-20-0
MF:
C23H28O6
Structure:
Chemical Name:
Pyrimidine, 4-chloro-5-nitro-2-(propylthio)-
CAS:
2518331-26-3
MF:
C7H8ClN3O2S
Chemical Name:
Oseltamivir Impurity 110
Chemical Name:
Oseltamivir Impurity 108