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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Chemical Name:
Ticagrelor Impurity 1
Chemical Name:
Ezetimibe Impurity 36
Chemical Name:
Pitavastatin Impurity 2
Chemical Name:
Fudosteine Impurity 2
Chemical Name:
Sugammadex Impurity 18
Chemical Name:
Mirabegron Impurity 21
Structure:
Chemical Name:
Apixaban Impurity 18
CAS:
473927-65-0
MF:
C20H17IN4O3
Structure:
Chemical Name:
Clopidogrel Impurity 12
MF:
C15H14ClNO2S
Chemical Name:
Oseltamivir Impurity 25
Chemical Name:
Ritonavir EP Impurity P
Structure:
Chemical Name:
Tacrolimus Impurity 4
CAS:
686773-61-5
MF:
C44H69NO12
Structure:
Chemical Name:
(2R,4S)-isopropyl5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1- yl)-2-methylpentanoate
MF:
C25H29NO4
Structure:
Chemical Name:
methyl 3-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-3- oxopropanoate hydrochloride
MF:
C16H24ClNO5
Chemical Name:
Aprepitant iMpurity 37
Structure:
Chemical Name:
Vitamin E Impurity 3
CAS:
1560705-69-2
MF:
C29H50O2
Structure:
Chemical Name:
(trans)-phenyl3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4'-fluoro-[1,1'-biphenyl]-3-yl)piperidine-1-carboxylate
MF:
C32H28FNO5
Chemical Name:
arformoterol tartrate impurity
Chemical Name:
Cefraprazole impurity
Structure:
Chemical Name:
JZWUWLJCMMPASK-YTSMVRMISA-N
CAS:
147103-95-5
MF:
C24H24N4O7S
Structure:
Chemical Name:
KXEITTOLAUJQPU-UHFFFAOYSA-N
CAS:
1797832-43-9
MF:
C20H21N7O2S
Structure:
Chemical Name:
GPZGXSFHPLUMHE-KEUNHQLVSA-N
CAS:
157054-84-7
MF:
C52H81NO13
Structure:
Chemical Name:
IRLGOHSHDYCIAB-ZMVBZRCWSA-N
CAS:
1076198-14-5
MF:
C19H23F3N2O5
Structure:
Chemical Name:
AOEGVETYSHPGBP-XYIDDFOTSA-N
CAS:
1887057-05-7
MF:
C41H55NO14
Structure:
Chemical Name:
4,6-DIAMINOINDAZOLE
CAS:
885518-52-5
MF:
C7H8N4
Structure:
Chemical Name:
12-Deoxy Roxithromycin
CAS:
425365-65-7
MF:
C41H76N2O14
Structure:
Chemical Name:
1-(1-oxidopyridin-1-ium-2-yl)-1-phenylethanol
CAS:
100393-43-9
MF:
C13H13NO2
Structure:
Chemical Name:
(R)-(R)-1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate(WXC03446)
CAS:
616866-21-8
MF:
C18H25NO3
Structure:
Chemical Name:
(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzoic acid
MF:
C18H22N4O4
Structure:
Chemical Name:
6'-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3'-bipyridin]-5-amine
MF:
C18H17N3O2S
Chemical Name:
Diquafosol Impurity 4
Chemical Name:
Tofacitinib Impurity X
Structure:
Chemical Name:
3-pentylideneisobenzofuran-1(3H)-one
CAS:
90965-68-7
MF:
C13H14O2
Chemical Name:
Labetalol EP impurity E
Structure:
Chemical Name:
1-Propanol, 3-(2-methoxy-5-nitrophenoxy)-
CAS:
1156068-41-5
MF:
C10H13NO5
Structure:
Chemical Name:
1616710-52-1
CAS:
1616710-52-1
MF:
C27H34N2O6
Chemical Name:
Bendamustine Related Impurity 22
Chemical Name:
Bendamustine Related Impurity 9
Structure:
Chemical Name:
Edoxaban Impurity 20 (1R,2R,4S)
CAS:
1928729-31-0
MF:
C16H29N3O7
Structure:
Chemical Name:
Edoxaban Impurity 40
CAS:
2081883-52-3
MF:
C14H27N3O3
Chemical Name:
Everolimus Impurity 2
Chemical Name:
Levosimendan Impurity 2 (Mixture ofZandEIsomers)
Structure:
Chemical Name:
N-(2,3-Dichloro-phenyl)-N'-[2-(2,3-dichloro-phenylamino)-ethyl]-ethane-1,2-diamine
MF:
C16H17Cl4N3
Structure:
Chemical Name:
Solifenacin Related Compound 29
CAS:
861998-77-8
MF:
C23H26N2O3
Chemical Name:
Ticagrelor Impurity 31
Chemical Name:
Afatinib Impurity QAQ
Structure:
Chemical Name:
Afatinib Impurity SHO
CAS:
2223677-65-2
MF:
C38H30Cl2F2N8O6
Structure:
Chemical Name:
Androstan-17-one,3-[[(4-methylphenyl)sulfonyl]oxy]-,(3,5)-
CAS:
10429-07-9
MF:
C26H36O4S
Structure:
Chemical Name:
Cabozantinib Impurity 48
CAS:
202916-99-2
MF:
C17H15NO3
Chemical Name:
Landiolol impurity R
Structure:
Chemical Name:
6-Oxo-Palonosetron
CAS:
848074-10-2
MF:
C19H22N2O2
Chemical Name:
Teneligliptin Impurity 8
Chemical Name:
(trans)-4-(4'-fluoro-[1,1'-biphenyl]-3-yl)-1-methylpiperidin-3-yl) methanol
Structure:
Chemical Name:
2,4(1H,3H)-Pyrimidinedione, 3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-
CAS:
2354391-45-8
MF:
C13H10F4N2O2
Structure:
Chemical Name:
Cyclopropane, nitroso-
CAS:
28017-92-7
MF:
C3H5NO
Structure:
Chemical Name:
Ticagrelor Related Compound 46
CAS:
2205903-73-5
MF:
C28H42ClN9O8S2
Structure:
Chemical Name:
Ticagrelor Related Compound 71
CAS:
1548397-10-9
MF:
C7H8ClN3O3S
Chemical Name:
Ticagrelor Related Compound 76
Chemical Name:
Vonoprazan Impurity 25
Structure:
Chemical Name:
1-(3,4-Dimethoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
CAS:
1255909-25-1
MF:
C11H17NO4S
Chemical Name:
Adefovir Impurity C
Chemical Name:
Blonanserin Impurity M
Chemical Name:
Brexpiprazole Impurity H
Chemical Name:
Cefaclor EP Impurity H
Chemical Name:
Flupentixol Impurity B
Structure:
Chemical Name:
Ipratropium Bromide Impurity J
MF:
C20H29Br2NO3
Structure:
Chemical Name:
Taladafil impurity
CAS:
1356345-67-9
MF:
C23H23N3O4
Structure:
Chemical Name:
Mirabegron 2-Oxo Impurity
CAS:
1684453-05-1
MF:
C21H22N4O3S
Structure:
Chemical Name:
Riluzole 4-Bromo Impurity
CAS:
144631-82-3
MF:
C8H4BrF3N2OS
Structure:
Chemical Name:
Furosemide Impurity 8
CAS:
41332-59-6
MF:
C7H4Cl2O5S
Structure:
Chemical Name:
Irinotecan Impurity 29
CAS:
797762-11-9
MF:
C22H24N2O4
Chemical Name:
Empagliflozin Impurity 41
Chemical Name:
Empagliflozin Impurity 47
Structure:
Chemical Name:
Irbesartan
CAS:
141745-36-0
MF:
C23H26N6O
Structure:
Chemical Name:
Aprepitant
CAS:
170902-80-4
MF:
C20H18F7NO2
Structure:
Chemical Name:
Pranoprofen Impurity 5
CAS:
145986-74-9
MF:
C16H15NO3
Structure:
Chemical Name:
Fluconazole Impurity
CAS:
1609495-95-5
MF:
C15H14FN9O
Structure:
Chemical Name:
1,4-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)- 1,4,8,11-tetraazacyclotetradecane dodecahydrochloride
MF:
C46H96Cl12N12
Chemical Name:
Entacapone Impurity 6
Structure:
Chemical Name:
Apremilast Impurity 15
CAS:
2096492-41-8
MF:
C22H26N2O8S
Structure:
Chemical Name:
Erythromycin EP Impurity L
CAS:
127955-44-6
MF:
C37H65NO14
Structure:
Chemical Name:
Levetiracetam impurity 1
CAS:
1342566-28-2
MF:
C8H16N2O3
Structure:
Chemical Name:
2-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)acetohydrazide hydrochloride
CAS:
1485732-85-1
MF:
C8H11F3N6O
Structure:
Chemical Name:
(R)-N-(1-(3-(2-cyano-5-fluorobenzyl)-1-methyl-2,6-dioxo- 1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)formamide
CAS:
2087874-91-5
MF:
C19H20FN5O3
Chemical Name:
Abiraterone Impurity 12
Chemical Name:
Atracurium Impurity O
Chemical Name:
Emtricitabine Impurity F
Structure:
Chemical Name:
Pitavastatin Impurity 44
CAS:
586966-55-4
MF:
C29H32FNO4
Chemical Name:
Tirofiban Impurity F
Chemical Name:
Tofacitinib Impurity 74
Chemical Name:
Tofacitinib Impurity 83
Structure:
Chemical Name:
Apixaban Impurity 31
CAS:
2458079-10-0
MF:
C27H30N4O6
Chemical Name:
Apixaban Impurity 38
Chemical Name:
Atracurium Impurity 4
Chemical Name:
Aztreonam Impurity 4
Structure:
Chemical Name:
Bendamustine Impurity 29
CAS:
847588-86-7
MF:
C19H22N6
Chemical Name:
Bendamustine Impurity 35
Chemical Name:
Cefoxitin Impurity 3
Chemical Name:
Doripenem Impurity 5
Chemical Name:
Erlotinib Impurity 47
Structure:
Chemical Name:
Etoposide EP Impurity A
CAS:
124151-67-3
MF:
C37H38O15