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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Chemical Name:
Tadalafil EP Impurity I
Structure:
Chemical Name:
1,4'-Bipiperidine, 1'-(phenylmethyl)-
CAS:
116269-53-5
MF:
C17H26N2
Structure:
Chemical Name:
[2-(4-Methoxyphenyl)-1-methylethyl]-formamide
CAS:
126002-14-0
MF:
C11H15NO2
Structure:
Chemical Name:
4,5,6,7-Tetrahydro-thieno[3,2-c]pyridin-2-ol 2-acetate
CAS:
1151904-85-6
MF:
C9H11NO2S
Structure:
Chemical Name:
ethyl (R)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
CAS:
110548-06-6
MF:
C15H13F2NO4
Structure:
Chemical Name:
methyl (Z)-3-(((4-(2-(4-(2-((4-((((Z)-6-(methoxymethyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)piperazin-1-yl)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS:
2097505-01-4
MF:
C56H54N8O7
Structure:
Chemical Name:
Roxithromycin EP Impurity J
CAS:
134834-12-1
MF:
C40H73ClN2O14
Structure:
Chemical Name:
Venlafaxine D6
CAS:
940297-06-3
MF:
C17H27NO2
Chemical Name:
Levosimendan Impurity 3
Chemical Name:
Sofosbuvir Impurity29
Chemical Name:
Acarbose Impurity A
Structure:
Chemical Name:
Levosimendan Impurity 1
CAS:
1643439-59-1
MF:
C22H23N7O2
Chemical Name:
Atomoxetine EP Impurity F
Chemical Name:
Quetiapine EP Impurity Q
Chemical Name:
Cefoxitin Impurity
Chemical Name:
Acemetacin Impurity
Structure:
Chemical Name:
ethyl (S)-6,7,8-trifluoro-1-(1-hydroxypropan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS:
110548-03-3
MF:
C15H14F3NO4
Structure:
Chemical Name:
ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate
CAS:
4792-57-8
MF:
C12H16N2O3
Structure:
Chemical Name:
(3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE
CAS:
79130-51-1
MF:
C11H16ClN
Structure:
Chemical Name:
Dasatinib N-Oxide
CAS:
910297-52-8
MF:
C22H26ClN7O3S
Structure:
Chemical Name:
(R)-9-[2-(DIETHYLPHOSPHONOMETHOXY)PROPYL] ADENINE
CAS:
180587-75-1
MF:
C13H22N5O4P
Structure:
Chemical Name:
P-TOLYL-PROPYNOIC ACID ETHYL ESTER
CAS:
52188-06-4
MF:
C12H12O2
Structure:
Chemical Name:
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid methyl ester
CAS:
42019-07-8
MF:
C18H17ClO4
Structure:
Chemical Name:
ACT 373898
CAS:
1433875-14-9
MF:
C15H17BrN4O5S
Structure:
Chemical Name:
Reaxys ID: 3623864
CAS:
129385-61-1
MF:
C17H10ClNO3
Chemical Name:
Olaparib Impurity D
Structure:
Chemical Name:
1-methylpyrrolidin-3-yl 2-(cyclopentyloxy)-2-phenylacetate
MF:
C18H25NO3
Chemical Name:
Cabozantinib impurity A
Structure:
Chemical Name:
Loratadine Impurity 2
MF:
C22H23ClN2O2
Structure:
Chemical Name:
Metoprolol Impurity 1
MF:
C15H25NO3
Chemical Name:
Pitavastatin Impurity 1
Chemical Name:
Trifluridine Impurity 3
Chemical Name:
Vonoprazan Impurity 1
Chemical Name:
Vonoprazan Impurity 4
Chemical Name:
Cinacalcet impurity K
Structure:
Chemical Name:
Valsartan Impurity 13
MF:
C24H29N5O3
Structure:
Chemical Name:
Valsartan Impurity 27
MF:
C24H29N5O3
Chemical Name:
Etoricoxib Impurity 6
Chemical Name:
Ezetimibe impurity 3
Chemical Name:
Apremilast Impurity C
Structure:
Chemical Name:
bis(1-benzylpiperidin-3-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS:
166808-97-5
MF:
C16H16N2O6
Structure:
Chemical Name:
Ticagrelor Imp.J
CAS:
2248538-63-6
MF:
C14H20ClN5O4S
Structure:
Chemical Name:
Vortioxetine Imp.E
CAS:
508233-77-0
MF:
C18H22N2S
Structure:
Chemical Name:
(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-(p-tolyl)propyl)-4-(4-hydroxyphenyl)azetidin-2-one
CAS:
1700622-07-6
MF:
C25H24FNO3
Chemical Name:
Topiroxostat Impurity 1
Chemical Name:
Oxcarbazepine Impurity3
Chemical Name:
Mosapride IMP
Structure:
Chemical Name:
4-Ethoxy Paroxetine
CAS:
606968-04-1
MF:
C21H25NO4
Structure:
Chemical Name:
Methylene-Bis Paroxetine
CAS:
1292846-10-6
MF:
C39H40F2N2O6
Structure:
Chemical Name:
Trelagliptin Impurity X
CAS:
1938080-44-4
MF:
C18H22FN5O3
Structure:
Chemical Name:
Afatinib Impurity 19
CAS:
1245555-42-3
MF:
C21H21ClFN5O2
Chemical Name:
Cefoxitin Sodium impurity
Structure:
Chemical Name:
(1S,2S,3S)-Aprepitant
CAS:
1242175-40-1
MF:
C23H21F7N4O3
Structure:
Chemical Name:
2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester
CAS:
1455091-06-1
MF:
C25H25NO7S
Structure:
Chemical Name:
cis-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride
CAS:
79617-89-3
MF:
C17H17Cl2N.HCl
Structure:
Chemical Name:
2,4-DIMETHYLDIPHENYLSULFIDE
CAS:
16704-47-5
MF:
C14H14S
Structure:
Chemical Name:
Dibenz[b,e]oxepin-11(6H)-one
CAS:
4504-87-4
MF:
C14H10O2
Structure:
Chemical Name:
2-CHLORO-1-(4,5-DICHLORO-2-THIENYL)ETHAN-1-ONE
CAS:
64218-50-4
MF:
C6H3Cl3OS
Structure:
Chemical Name:
(5Z,7E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19)-trien-24-one
CAS:
126860-84-2
MF:
C27H40O3
Structure:
Chemical Name:
(-)-3-Demethylcolchicine
CAS:
7336-33-6
MF:
C21H23NO6
Structure:
Chemical Name:
3',5'-Dimethoxytricetin 7-O-β-D-glucopypranoside
CAS:
32769-01-0
MF:
C23H24O12
Structure:
Chemical Name:
1,3-Dimethyl-5,5-diallylhexahydropyrimidine-2,4,6-trione
CAS:
722-97-4
MF:
C12H16N2O3
Structure:
Chemical Name:
Pseudomonic acid C
CAS:
71980-98-8
MF:
C26H44O8
Structure:
Chemical Name:
Cytarabine Impurity 12
CAS:
14057-18-2
MF:
C15H18N2O9
Structure:
Chemical Name:
D,L-O-DesMethyl Venlafaxine-d6
CAS:
1062605-69-9
MF:
C16H19D6NO2
Structure:
Chemical Name:
(E)-3-[p-Bromomethylphenyl]acrylic acid ethyl ester
CAS:
78712-67-1
MF:
C12H13BrO2
Structure:
Chemical Name:
3-Amino-2-butenoic acid
CAS:
21112-45-8
MF:
C4H7NO2
Structure:
Chemical Name:
DU 6858
CAS:
127199-06-8
MF:
C19H18ClF2N3O3
Structure:
Chemical Name:
rac 4-[4-(Oxiranylmethoxy)-1,2,5-thiadiazol-3-yl]morpholine
CAS:
58827-68-2
MF:
C9H13N3O3S
Structure:
Chemical Name:
N-Formyl-L-leucine (3S,4S,6S)-3-Hexyltetrahydro-2-oxo-6-undecyl-2H-pyran-4-yl Ester
CAS:
130676-65-2
MF:
C29H53NO5
Structure:
Chemical Name:
rac a-Hydroxy Ibuprofen
CAS:
60057-62-7
MF:
C13H18O3
Structure:
Chemical Name:
3a,7a-dihydroxy-5-(1-methyl-1H-indole-3-carbonyl)-hexahydro-1H-benzo[d]imidazol-2(3H)-one
CAS:
171967-74-1
MF:
C17H19N3O4
Structure:
Chemical Name:
6-(2,5-dichlorophenyl)-1,3,5-Triazine-2,4(1H,3H)-dione
CAS:
30222-00-5
MF:
C9H5Cl2N3O2
Structure:
Chemical Name:
(2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-uridine 3',5'-dibenzoate
CAS:
863329-65-1
MF:
C24H21FN2O7
Chemical Name:
Anastrozole iMpurityC
Chemical Name:
Celecoxib iMpurity-A
Chemical Name:
EMtricitabine iMpurity A
Chemical Name:
Ondansetron Impurity B
Structure:
Chemical Name:
LeflunoMide EP IMpurity F
CAS:
1403564-06-6
MF:
C12H9F3N2O2
Chemical Name:
4'-((1,7'-dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazol-1'-yl)methyl)biphenyl-2-carboxylic acid
Chemical Name:
Itraconazole iMpurity D
Structure:
Chemical Name:
3-amino-2-chloroacrolein
CAS:
221615-73-2
MF:
C3H4ClNO
Structure:
Chemical Name:
3-Amino-4-pyrazolecarbonitrile
CAS:
16617-46-2
MF:
C4H4N4
Structure:
Chemical Name:
BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)-
CAS:
1391052-24-6
MF:
C20H20Cl2N2O3
Structure:
Chemical Name:
4-ISOBUTYRYLACETOPHENONE
CAS:
103931-20-0
MF:
C12H14O2
Structure:
Chemical Name:
ButanaMide, 4-hydroxy-N-(1-Methylethyl)-
CAS:
42042-66-0
MF:
C7H15NO2
Structure:
Chemical Name:
5H-chroMeno[2,3-b]pyridin-7-ylacetic acid
CAS:
52549-07-2
MF:
C14H11NO3
Structure:
Chemical Name:
((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid
CAS:
1132709-15-9
MF:
C19H25BN4O4
Structure:
Chemical Name:
(S)-N-(1-AMino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
CAS:
289472-80-6
MF:
C14H14N4O2
Structure:
Chemical Name:
(3aS,4R,6S,6aR)-6-AMinotetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-ol
CAS:
592533-90-9
MF:
C8H15NO3
Structure:
Chemical Name:
(4R,6S)-tert-Butyl-6-cyanoMethyl-2,2-diMethyl-1,3-dioxane-4-acetate
CAS:
196085-84-4
MF:
C14H23NO4
Structure:
Chemical Name:
(1R,2R,3S,5R)-3-(7-((1S,2R)-2-(3,4-difluorophenyl)cyclopropylaMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
CAS:
2096989-55-6
MF:
C23H28F2N6O4S
Structure:
Chemical Name:
Rivaroxaban iMpurity
CAS:
1616563-62-2
MF:
C15H17N3O5
Structure:
Chemical Name:
AMoxicillin iMpurity K
MF:
C16H19N3O5S
Chemical Name:
cefoxitin iMpurity D
Structure:
Chemical Name:
3-Morpholinone, 4-(2,4-diaMinophenyl)-
CAS:
482308-13-4
MF:
C10H13N3O2
Structure:
Chemical Name:
BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-
CAS:
174227-14-6
MF:
C25H25N5O5S
Structure:
Chemical Name:
BenzaMide, N-[1-(3,5-di-O-benzoyl-2-C-Methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyriMidinyl]-
CAS:
863329-62-8
MF:
C31H27N3O8
Chemical Name:
Fosfluconazole iMpurity
Structure:
Chemical Name:
Cinacalcet Impurity D
CAS:
1271930-15-4
MF:
C32H31F6N