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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Chemical Name:
RocuroniuMbroMide iMpurity D
Chemical Name:
IMp. B (EP): (2RS,4S)-2-[[[[3-(2-Chloro-6-fluorophenyl)-5-Methylisoxazol-4-yl]carbonyl]aMino]Methyl]-5,5-diMethyl- thiazolidine-4-carboxylic Acid (Penilloic Acids of Flucloxacillin)
Structure:
Chemical Name:
IMp. C (EP): (4-(DiphenylMethyl)-1,1-bis[(E)-3-phenylprop-2-enyl]piperaziniuM Chloride
CAS:
95062-18-3
MF:
C35H35ClF2N2
Structure:
Chemical Name:
AtracuriuM IMpurity D2 (cis-Quaternary Alcohol)
CAS:
1100676-16-1
MF:
C35H47NO10S
Chemical Name:
AzithroMycin IMpurity O
Structure:
Chemical Name:
BendaMustine Dihydroxy IMpurity
CAS:
109882-29-3
MF:
C16H24ClN3O4
Structure:
Chemical Name:
BroMocriptine IMpurity G
MF:
C32H40BrN5O5
Structure:
Chemical Name:
Captopril IMpurity H
CAS:
205521-07-9
MF:
C15H23NO5S2
Structure:
Chemical Name:
Cefdinir IMpurity 3 (Cefdinir Decarboxy Open Ring Lactone (Mixture of A and B))
CAS:
178949-04-7
MF:
C13H15N5O4S2
Chemical Name:
Ceftriaxone IMpurit D
Structure:
Chemical Name:
Ciprofloxacin Related CoMpound
CAS:
528851-30-1
MF:
C15H17Cl2N3O3
Chemical Name:
Dasatinib IMpurity 4
Structure:
Chemical Name:
Deferasirox Methyl Ester
CAS:
1266741-05-2
MF:
C22H17N3O4
Structure:
Chemical Name:
Deltacortinene Acetate (Predisolone Acetate IMpurity)
CAS:
4380-55-6
MF:
C23H28O5
Chemical Name:
Entecavir IMpurity A
Structure:
Chemical Name:
Fasudil IMpurity 1
CAS:
1423155-03-6
MF:
C14H17N3O2S
Structure:
Chemical Name:
Irbesartan IMpurity
CAS:
1079997-01-5
MF:
C26H30N6O2
Chemical Name:
Montelukast EP IMpurity I
Structure:
Chemical Name:
5-(5-Chlorosulfonyl-2-ethoxyphenyl)-3-propyl-1,6-dihydro_x000b_-7H-pyrazolo[4,3-d]pyrimidin-7-one
CAS:
139756-31-3
MF:
C16H17ClN4O4S
Structure:
Chemical Name:
5,7-difluorochroman-4-one
CAS:
844648-22-2
MF:
C9H6F2O2
Structure:
Chemical Name:
2-[(Azidoacetyl)amino]-2-deoxy-D-glucopyranose 1,3,4,6-tetraacetate
CAS:
98924-81-3
MF:
C16H22N4O10
Structure:
Chemical Name:
(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid
CAS:
769908-13-6
MF:
C25H24FNO4
Structure:
Chemical Name:
(7a,17b)-7-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3,17-diol 17-acetate
CAS:
261506-24-5
MF:
C34H49F5O4S
Structure:
Chemical Name:
O-Desethyl Candesartan Cilexetil
CAS:
869631-11-8
MF:
C31H30N6O6
Structure:
Chemical Name:
α-Desmethyl Anastrozole
CAS:
1215780-15-6
MF:
C16H17N5
Structure:
Chemical Name:
Epi Lovastatin
CAS:
79952-44-6
MF:
C24H36O5
Structure:
Chemical Name:
Hydroxy Brimonidine
CAS:
1216379-05-3
MF:
C11H12BrN5O
Structure:
Chemical Name:
3-methyleneisobenzofuran-1(3H)-one
CAS:
3453-63-2
MF:
C9H6O2
Structure:
Chemical Name:
Irbesartan impurity A
MF:
C25H28N6O
Structure:
Chemical Name:
RaceMic Fudosteine HCl
CAS:
1023971-15-4
MF:
C6H13NO3S
Chemical Name:
RocuroniuM BroMide IMpurity 18
Structure:
Chemical Name:
SalMeterol IMpurity E
MF:
C25H37NO4
Chemical Name:
SulbactaM IMpurity C
Structure:
Chemical Name:
Terazosin IMpurity J
CAS:
152551-75-2
MF:
C19H27N5O4
Structure:
Chemical Name:
Ticarcillin SodiuM IMpurity A
CAS:
36041-93-7
MF:
C14H16N2O4S2
Structure:
Chemical Name:
R-afatinib
CAS:
945553-91-3
MF:
C24H25ClFN5O3
Structure:
Chemical Name:
EthanediaMide iMpurity E
MF:
C2H4N2O2
Structure:
Chemical Name:
Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate
CAS:
1206875-41-3
MF:
C15H22N2O2
Structure:
Chemical Name:
S-(-)-[1-(3-Methoxyphenyl)ethyl]-N,N-diMethylaMine
CAS:
889443-69-0
MF:
C11H17NO
Structure:
Chemical Name:
N-(4-aMinophenyl)-2-chloro-N-MethylacetaMide
CAS:
855860-75-2
MF:
C9H11ClN2O
Structure:
Chemical Name:
Ibrutinib iMpurity
CAS:
936351-48-3
MF:
C12H13ClN2O
Structure:
Chemical Name:
1-Phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one
CAS:
381725-50-4
MF:
C16H12N2O
Structure:
Chemical Name:
Abacavir Impurity E
CAS:
208762-35-0
MF:
C14H20N6O
Structure:
Chemical Name:
(1R,5S,6R)-rel-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester
CAS:
347378-74-9
MF:
C14H22O4
Structure:
Chemical Name:
(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt
CAS:
254452-96-5
MF:
C25H24FNO4
Structure:
Chemical Name:
(αZ)-α-(MethoxyiMino)-N-[(5aR,6R)-1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl]-2-furanacetaMide
CAS:
947723-87-7
MF:
C15H13N3O6S
Structure:
Chemical Name:
1-[[2-[(2-AMinophenyl)aMino]-5-Methyl-3-thienyl]carbonyl]-4-Methyl-piperazine
CAS:
138564-61-1
MF:
C17H22N4OS
Structure:
Chemical Name:
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester
CAS:
452092-31-8
MF:
C15H13F2NO4
Structure:
Chemical Name:
2-(IsopropylaMino)-2',6'-acetoxylidide Hydrochloride
CAS:
35891-87-3
MF:
C13H21ClN2O
Structure:
Chemical Name:
2,2'-IMinobis(N-(2,6-DiMethylphenyl)acetiaMide Hydrochloride
CAS:
1135231-62-7
MF:
C20H26ClN3O2
Structure:
Chemical Name:
3,4-O-(DiethylMethylidene) ShikiMic Acid Ethyl Ester
CAS:
943515-58-0
MF:
C14H22O5
Structure:
Chemical Name:
4-Hydroxy-α1-[[[6-(2-phenylethoxy)hexyl]aMino]Methyl]-1,3-benzenediMethanol
CAS:
94749-02-7
MF:
C23H33NO4
Structure:
Chemical Name:
5-[2-Ethoxy-5-[(4-Methyl-1-piperazinyl)thioxoMethyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-7H-pyrazolo[4,3-d]pyriMidine-7-thione
CAS:
1333233-46-7
MF:
C23H30N6OS2
Structure:
Chemical Name:
BIRG 613 BS
CAS:
287980-85-2
MF:
C15H16N4O
Structure:
Chemical Name:
(S)-(+)-3-HYDROXYTETRAHYDROFURAN
CAS:
79107-75-8
MF:
C4H8OS
Structure:
Chemical Name:
TRIBENZYLPHOSPHITE
CAS:
15205-57-9
MF:
C21H21O3P
Structure:
Chemical Name:
4-Chlor-3-nitro-5-sulfobenzoesure
CAS:
130262-91-8
MF:
C7H4ClNO7S
Structure:
Chemical Name:
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
CAS:
106261-48-7
MF:
C13H18N2O2
Structure:
Chemical Name:
(D-LYS16)-ACTH (1-24) (HUMAN, BOVINE, MOUSE, OVINE, PORCINE, RABBIT, RAT)
CAS:
494750-52-6
MF:
C136H210N40O31S
Structure:
Chemical Name:
1-(diaminomethylidene)-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]urea
CAS:
2508-80-7
MF:
C7H14N4O5
Structure:
Chemical Name:
3-(2-amino-1-hydroxyethyl)benzene-1,2-diol
CAS:
73660-93-2
MF:
C8H11NO3
Structure:
Chemical Name:
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzonitrile
CAS:
641571-12-2
MF:
C12H8F3N3
Structure:
Chemical Name:
17-BETA-ESTRADIOL 3-METHYL ETHER
CAS:
1474-53-9
MF:
C19H26O3
Structure:
Chemical Name:
1-(1H-benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid
CAS:
1163685-30-0
MF:
C14H11N3O3
Structure:
Chemical Name:
7-Methoxy-3,4-dihydro-1H-quinolin-2-one
CAS:
22246-17-9
MF:
C10H11NO2
Structure:
Chemical Name:
4-Methoxy-alpha-methyl-N-(phenylmethyl)benzeneethanamine hydrochloride
CAS:
1049695-95-5
MF:
C17H21NO.HCl
Structure:
Chemical Name:
Montelukast Methyl Ketone
CAS:
937275-23-5
MF:
C34H32ClNO3S
Structure:
Chemical Name:
Propyl Itraconazole
CAS:
74855-91-7
MF:
C34H36Cl2N8O4
Structure:
Chemical Name:
Olmesartan Methyl Ketone
CAS:
1227626-45-0
MF:
C25H28N6O2
Structure:
Chemical Name:
(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-nitrophenylethylaMine
CAS:
223673-35-6
MF:
C21H26N2O5
Structure:
Chemical Name:
Azelastine N-Oxide
CAS:
640279-88-5
MF:
C22H24ClN3O2
Structure:
Chemical Name:
Desloratadine Hydroxypiperidine N-Oxide
CAS:
1193725-75-5
MF:
C19H15ClN2O2
Structure:
Chemical Name:
16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione
CAS:
3754-05-0
MF:
C21H26O6
Structure:
Chemical Name:
4H-Furo[2,3-c]pyranyl Mupirocin SodiuM IMpurity
CAS:
116182-43-5
MF:
C26H43NaO9
Structure:
Chemical Name:
4-Methyl Erlotinib Hydrochloride
CAS:
1346601-52-2
MF:
C23H25N3O4
Structure:
Chemical Name:
5-[[(4-Fluorophenyl)Methyl]aMino]-1,3-dihydro-2H-iMidazo[4,5-b]pyridin-2-one
CAS:
951624-49-0
MF:
C13H11FN4O
Structure:
Chemical Name:
Perindoprilat LactaM B
CAS:
130061-28-8
MF:
C17H26N2O4
Structure:
Chemical Name:
PseudoMonic Acid D SodiuM
CAS:
85178-60-5
MF:
C26H41NaO9
Structure:
Chemical Name:
N-DesMethyl SuMatriptan
CAS:
88919-51-1
MF:
C13H19N3O2S
Structure:
Chemical Name:
2-epi-(-)-EMtricitabine
CAS:
145416-34-8
MF:
C8H10FN3O3S
Structure:
Chemical Name:
Parent nucleus of cefotiaM hydrochloride
CAS:
372092-19-8
MF:
C13H21N7O3S2
Structure:
Chemical Name:
Bisacodyl Related Compound E (20 mg) (2-[(4-Acetoxyphenyl)(pyridin-2-yl)methyl]phenyl acetate)
CAS:
111664-35-8
MF:
C22H19NO4
Structure:
Chemical Name:
Triamterene Related Compound B (50 mg) (2,7-diamino-4-hydroxy-6-phenylpteridine)
CAS:
19375-89-4
MF:
C12H10N6O
Structure:
Chemical Name:
EsoMeprazole related substance H431/41
CAS:
1227380-90-6
MF:
C16H15N3O4
Structure:
Chemical Name:
(3S,4R)-4-(4-Fluorophenyl)piperidine-3-Methanol Hydrochloride
CAS:
220548-73-2
MF:
C12H17ClFNO
Structure:
Chemical Name:
LaMotrigine IMpurity D
CAS:
661463-79-2
MF:
C9H5Cl2N3O2
Structure:
Chemical Name:
(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol N-Oxide Sulfate
MF:
C24H31NO5S
Structure:
Chemical Name:
DeMethylpiperazinyl Desethyl Sildenafil Sulfonyl Chloride
CAS:
139756-27-7
MF:
C15H15ClN4O4S
Structure:
Chemical Name:
Rizatriptan IMpurity B
CAS:
1016900-28-9
MF:
C13H15ClN5
Structure:
Chemical Name:
rac Adrenaline IMpurity D
CAS:
1095714-91-2
MF:
C16H19NO3
Structure:
Chemical Name:
2-(1-Methylethenyl)-6-(1-Methylethyl)phenol
CAS:
74926-89-9
MF:
C12H16O
Structure:
Chemical Name:
Irinotecan IMpurity G
CAS:
947687-02-7
MF:
C35H42N4O6
Structure:
Chemical Name:
5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid
CAS:
109882-30-6
MF:
C16H23N3O4
Structure:
Chemical Name:
5-Chloro-6'-Methyl-3-[4-(Methylsulfonyl)phenyl]-2,3'-bipyridine 1'-Oxide
CAS:
325855-74-1
MF:
C18H15ClN2O3S
Structure:
Chemical Name:
Lafutidine IMpuritiy B
CAS:
174583-84-7
MF:
C22H29N3O5S
Structure:
Chemical Name:
N-(Methylsulfonyl)-N-(2-phenoxyphenyl)MethanesulfonaMide
CAS:
905858-63-1
MF:
C14H15NO5S2
Structure:
Chemical Name:
4,5-Dihydro-α,3-diMethyl-5-oxo-1-phenyl-α-sulfo-1H-pyrazole-4-acetic Acid
CAS:
1357477-99-6
MF:
C13H14N2O6S
Structure:
Chemical Name:
tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate
CAS:
763114-04-1
MF:
C25H27FN4O4
Structure:
Chemical Name:
1H-IMidazole, 4-Methyl-1-[3-nitro-5-(trifluoroMethyl)phenyl]-
CAS:
916975-92-3
MF:
C11H8F3N3O2
Structure:
Chemical Name:
Edaravone iMpurity P3
CAS:
1323485-71-7
MF:
C13H16N2O4S