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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure:
Chemical Name:
Cyclopropanamine, 2-(3-fluorophenyl)-, (1R,2S)- (9CI)
CAS:
220353-83-3
MF:
C9H10FN
Structure:
Chemical Name:
1(2H)-Naphthalenone, 4-hydroxy-3-methyl-2-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-ylidene]-
CAS:
693781-59-8
MF:
C31H40O2
Chemical Name:
Bisoprolol Impurity 50
Chemical Name:
Milnacipran Impurity 26
Chemical Name:
Olodaterol Impurity 15
Structure:
Chemical Name:
SRI 62320
CAS:
94061-80-0
MF:
C24H25FNNaO4
Structure:
Chemical Name:
Vitamin B12 e-Monocarboxylic Acid
CAS:
26264-28-8
MF:
C63H87CoN13O15P
Structure:
Chemical Name:
caffeidine
CAS:
20041-90-1
MF:
C7H12N4O
Structure:
Chemical Name:
digoxigenin-mono(digitoxoside)
CAS:
5352-63-6
MF:
C29H44O8
Chemical Name:
metreleptin
CAS:
186018-45-1
Structure:
Chemical Name:
3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID
CAS:
2055-97-2
MF:
C13H6I4O4
Structure:
Chemical Name:
Sotalol EP Impurity A
CAS:
16974-42-8
MF:
C12H20N2O2S
Structure:
Chemical Name:
W 36017
CAS:
21236-54-4
MF:
C12H18N2O
Structure:
Chemical Name:
ONO EI-601
CAS:
155023-59-9
MF:
C15H14N2O6S
Structure:
Chemical Name:
norchlorpromazine
CAS:
1225-64-5
MF:
C16H17ClN2S
Structure:
Chemical Name:
2-Amino-4-(3-chlorothien-2-yl)-1,3-thiazole
CAS:
339114-12-4
MF:
C7H5ClN2S2
Chemical Name:
Capecitabine Related Compound B
Chemical Name:
Alvatrombopag Impurity 84
Chemical Name:
Tafluprost Impurity 15
Chemical Name:
Rosuvastatin Impurity 159 (Sodium salt)
Chemical Name:
Rosuvastatin Impurity 140
Chemical Name:
Rosuvastatin Impurity 130
Chemical Name:
Terlipressin Impurity 1 (des-Gly1)
Chemical Name:
Brivaracetam Impurity 66
Structure:
Chemical Name:
2-Acetoxymethyl1-3-Methyl-4-
CAS:
112525-75-4
MF:
C11H12F3NO3
Chemical Name:
N-(7-chloro-4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-yl)-4-(dimethylamino)butanamide
Chemical Name:
Ertapenem Impurity D(USP)
Structure:
Chemical Name:
3-(N-Benzyl-N-methylamino)propiophenone hydrochloride
CAS:
5409-62-1
MF:
C17H20ClNO
Structure:
Chemical Name:
2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-4-hydroxy-1-phenyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (1S,4S)-
CAS:
869884-24-2
MF:
C23H26N2O3
Chemical Name:
Azilsartan Medoxomil Potassium impurity209
Chemical Name:
Pitavastatin Impurity 104
Chemical Name:
Avatrombopag Impurity 60
Structure:
Chemical Name:
D-erythro-3,4-Dihydroxyphenylserine
CAS:
51829-98-2
MF:
C9H11NO5
Structure:
Chemical Name:
aztreonam
CAS:
80951-91-3
MF:
C13H17N5O8S2
Structure:
Chemical Name:
5H-[1]Benzopyrano[2,3-b]pyridine,7-ethyl-(9CI)
CAS:
639857-68-4
MF:
C14H13NO
Structure:
Chemical Name:
[1,1-Biphenyl]-2,2,4,4,5,5-hexol(9CI)
CAS:
76625-61-1
MF:
C12H10O6
Chemical Name:
Esmolol Impurity 45
Chemical Name:
Oprinone Impurity 6
Structure:
Chemical Name:
lamivudine sulfoxide
CAS:
160552-55-6
MF:
C8H11N3O4S
Structure:
Chemical Name:
ETHYLISOPROPYLNITROSAMINE
CAS:
16339-04-1
MF:
C5H12N2O
Structure:
Chemical Name:
1,3,5,7-Tetrmethyl-adamantane
CAS:
1687-36-1
MF:
C14H24
Structure:
Chemical Name:
4-[1-(hydroxyamino)ethylidene]cyclohexa-2,5-dien-1-one
CAS:
34523-34-7
MF:
C8H9NO2
Structure:
Chemical Name:
Methyl 4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinecarboxylate
CAS:
121659-86-7
MF:
C20H16FNO2
Structure:
Chemical Name:
Silodosin
CAS:
160970-64-9
MF:
C25H32F3N3O4
Structure:
Chemical Name:
(3S)-6,6-DIBROMO-2,2-DIMETHYLPENAM-3-CARBOXYLIC ACID 1,1-DIOXIDE
CAS:
76646-91-8
MF:
C8H9Br2NO5S
Structure:
Chemical Name:
(S)-Citalopram N-Oxide
CAS:
917482-45-2
MF:
C20H21FN2O2
Structure:
Chemical Name:
7-Epi-docetaxel (Docetaxel Impurity C)
CAS:
153381-68-1
MF:
C43H53NO14
Structure:
Chemical Name:
Amido Methyl Meloxicam (Meloxicam Impurity)
CAS:
892395-41-4
MF:
C15H15N3O4S2
Structure:
Chemical Name:
4-Nitrofluorobenzol
CAS:
352-15-8
MF:
C6H4FNO
Structure:
Chemical Name:
propyl[2,6'-bi-1H-benzimidazol]-1'-yl]methyl]-
CAS:
144702-27-2
MF:
C33H29N5
Structure:
Chemical Name:
4-(2-Hydroxy-3-isopropylaminopropoxy)benzoic Acid
CAS:
72570-70-8
MF:
C13H19NO4
Structure:
Chemical Name:
Fluvoxamino Acid
CAS:
192876-02-1
MF:
C14H19F3N2O2
Structure:
Chemical Name:
Fluvastatin N-Ethyl Sodium Salt (Fluvastatin Impurity)
CAS:
93936-64-2
MF:
C23H23FNNaO4
Structure:
Chemical Name:
1-(4-hydroxy-2-methoxyphenyl)ethanone
CAS:
493-33-4
MF:
C9H10O3
Structure:
Chemical Name:
1-Demethyl Hydroxy Daunomycinone
CAS:
58199-98-7
MF:
C20H16O9
Structure:
Chemical Name:
(S)-2-(butylsulfonamido)-3-(4-(4-(1-methylpiperidin-4-yl)butoxy)phenyl)propanoic acid
CAS:
1631053-75-2
MF:
C23H38N2O5S
Chemical Name:
7-(but-2-yn-1-yl)-8-(3-(hydroxyimino)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
CAS:
1297273-94-9
Chemical Name:
Isavuconazole Impurity 35
Chemical Name:
Brivaracetam Impurity 26 HCl
Chemical Name:
Brivaracet amoxidation Impurity 1
Chemical Name:
Rosuvastatin EP Impurity G Complete Set
Chemical Name:
Bortezomib Impurity G Complete Set
Chemical Name:
Peramivir Diacetyl Impurity
Chemical Name:
Peramivir Chlorisomeric Impurity
Chemical Name:
Canagliflozin impurities 15 drops
Chemical Name:
Pemetrexed Impurities 41-45
Chemical Name:
Pemetrexed Disodium EP Impurity 999
Chemical Name:
Bumetanide Impurity 999
Chemical Name:
Canagliflozin Impurity 998
Chemical Name:
N,N-dimethyl-1,4,8,11-tetraazacyclotetradecane-1-sulfonamide
Chemical Name:
Tamsulosin EP Impurity C (Desethoxy Tamsulosin)
Chemical Name:
Itropopa Impurity 17
Chemical Name:
Cefazolin Epimer Cefazolin Impuirty M (USP), Cefazolin Impurity L (EP)
Structure:
Chemical Name:
Relugolix Impurity 66
CAS:
2591260-06-7
MF:
C25H24F2N2O6S
Chemical Name:
methyl 3-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-3- oxopropanoate
Chemical Name:
Δ3-7-ACT
Structure:
Chemical Name:
methyl 5-methyl-3'-nitro-3-oxo-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-carboxylate
CAS:
2469735-68-8
MF:
C15H15NO5
Structure:
Chemical Name:
Pregn-4-ene-3,20-dione, 9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
CAS:
3093-36-5
MF:
C24H33FO5
Structure:
Chemical Name:
2-(3-(4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
CAS:
2402776-84-3
MF:
C23H27N9O4S2
Structure:
Chemical Name:
Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminocarbonyl)amino]-2-hydroxy-, (1S,2S,3R,4R)-
CAS:
2597901-48-7
MF:
C15H27N3O5
Structure:
Chemical Name:
3-Isoquinolinecarboxylic acid, 7-(4-chlorophenoxy)-4-hydroxy-, methyl ester
CAS:
2711953-58-9
MF:
C17H12ClNO4
Chemical Name:
Tegoprazan Impurity 8
Structure:
Chemical Name:
Atomoxetine EP Impurity G DiHCl (Mixture of Diastereomers)
CAS:
2706536-33-4
MF:
C27H34N2O2
Chemical Name:
Nirmatrelvir Impurity 10
Chemical Name:
Levosimendan Nitrosogenin Impurities
Structure:
Chemical Name:
7-(ALPHA-BROMOACETAMIDO)CEPHALOSPORANIC ACID
CAS:
26973-80-8
MF:
C12H13BrN2O6S
Chemical Name:
Bumetanide Impurity 20
Chemical Name:
Rocuronium Bromide Impurity 28 、29
Chemical Name:
Roxadustat Impurity 22
Chemical Name:
Olaparib Impurity 41
Chemical Name:
Perospirone Impurity 22
Structure:
Chemical Name:
Perospirone Impurity 14
CAS:
87691-94-9
MF:
C15H20BrN3S
Chemical Name:
Dolutegravir Impurity 22
Chemical Name:
Paxlovid Impurity 20
Chemical Name:
Related impurities 7 of fluoxetine sodium
Chemical Name:
Revefenacin Impurity 16
Chemical Name:
Fondaparinux sodium impurity 8
Chemical Name:
Fondaparinux sodium impurity 14
Chemical Name:
Fondaparinux Sodium Impurity 9
Chemical Name:
Oxacillin sodium Impurity D