Exendin-3 (9-39) amide
Exendin-3 (9-39) amide Basic information
- Product Name:
- Exendin-3 (9-39) amide
- Synonyms:
-
- ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
- H-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
- EXENDIN 3 (9-39)
- EXENDIN-3 (9-39) AMIDE
- EXENDIN (9-39)
- EXENDIN (9-39) AMIDE
- EXENDIN [9-39] PEPTIDE
- EXENDIN FRAGMENT 9-39
- CAS:
- 133514-43-9
- MF:
- C149H234N40O47S
- MW:
- 3369.76
- Product Categories:
-
- Peptide
- GLP-1 Receptor LigandsObesity Research
- Cytokines Growth Factors and Hormones (Obesity)
- ExendinPeptides for Cell Biology
- Hormones
- Obesity Peptides
- Obesity Research
- Other Obesity Research Products
- Glucagon receptor and related
- Mol File:
- 133514-43-9.mol
Exendin-3 (9-39) amide Chemical Properties
- Density
- 1.51
- RTECS
- LF2460000
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- H2O : 50 mg/mL (14.84 mM; Need ultrasonic)
- form
- Solid
- color
- Off-white to pale purple
- Water Solubility
- Soluble in water at 1mg/ml
- InChIKey
- WSEVKKHALHSUMB-UHFFFAOYSA-N
MSDS
- Language:English Provider:SigmaAldrich
Exendin-3 (9-39) amide Usage And Synthesis
Description
Exendin-3 (9-39) amide is a truncated form of the exendin-4 peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1). It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM). Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 μg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats.
Uses
Biological probe.
Uses
Exendin-3 (9-39) is a potent and selective GLP-1 receptor antagonist.
General Description
Exendin Fragment 9-39 is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin.
Biochem/physiol Actions
GLP-1 (glucagon-like peptide-1) receptor antagonist. Competitive inhibitor of exendin-3 and exendin-4.
storage
Store at -20°C
Exendin-3 (9-39) amideSupplier
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