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Exendin-3 (9-39) amide

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Exendin-3 (9-39) amide Basic information

Product Name:
Exendin-3 (9-39) amide
Synonyms:
  • ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
  • H-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
  • EXENDIN 3 (9-39)
  • EXENDIN-3 (9-39) AMIDE
  • EXENDIN (9-39)
  • EXENDIN (9-39) AMIDE
  • EXENDIN [9-39] PEPTIDE
  • EXENDIN FRAGMENT 9-39
CAS:
133514-43-9
MF:
C149H234N40O47S
MW:
3369.76
Product Categories:
  • Peptide
  • GLP-1 Receptor LigandsObesity Research
  • Cytokines Growth Factors and Hormones (Obesity)
  • ExendinPeptides for Cell Biology
  • Hormones
  • Obesity Peptides
  • Obesity Research
  • Other Obesity Research Products
  • Glucagon receptor and related
Mol File:
133514-43-9.mol
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Exendin-3 (9-39) amide Chemical Properties

Density 
1.51
RTECS 
LF2460000
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
H2O : 50 mg/mL (14.84 mM; Need ultrasonic)
form 
Solid
Water Solubility 
Soluble in water at 1mg/ml
InChIKey
WSEVKKHALHSUMB-UHFFFAOYSA-N
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Safety Information

WGK Germany 
3

MSDS

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Exendin-3 (9-39) amide Usage And Synthesis

Description

Exendin-3 (9-39) amide is a truncated form of the exendin-4 peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1). It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM). Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 μg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats.

Uses

Biological probe.

Uses

Exendin-3 (9-39) is a potent and selective GLP-1 receptor antagonist.

General Description

Exendin Fragment 9-39 is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin.

Biochem/physiol Actions

GLP-1 (glucagon-like peptide-1) receptor antagonist. Competitive inhibitor of exendin-3 and exendin-4.

storage

Store at -20°C

Exendin-3 (9-39) amideSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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Chembest Research Laboratories Limited
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Shanghai Hanhong Scientific Co.,Ltd.
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