Basic information Safety Supplier Related

EXENDIN-4 (3-39)

Basic information Safety Supplier Related

EXENDIN-4 (3-39) Basic information

Product Name:
EXENDIN-4 (3-39)
Synonyms:
  • M.W. 3992.42 C176H272N46O58S
  • GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
  • EGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
  • EXENDIN-4 (3-39)
  • EXENDIN (3-39)
  • H-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
  • EGTFTSDLSK QMEEEAVRLF IEWLKNGGPS SGAPPPS -CONH2
CAS:
196109-31-6
MF:
C176H272N46O58S
MW:
3992.38128
Product Categories:
  • Glucagon receptor and related
  • peptide
Mol File:
196109-31-6.mol
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EXENDIN-4 (3-39) Chemical Properties

storage temp. 
-15°C
Sequence
H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
InChIKey
ZCYIPGKMSDDSFW-TYVQEZQOSA-N
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EXENDIN-4 (3-39) Usage And Synthesis

Uses

Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis[1][2].

in vivo

GLP-1 (i.p.; 5 μg/kg) increases circulating corticosterone and aldosterone levels[2].

Animal Model:Rats[2]
Dosage:5 μg/kg
Administration:Intraperitoneal injections
Result:Increased circulating corticosterone levels in a time-dependent manner both in conscious and anaesthetized rats and also increased aldosterone levels.

References

[1] David Parkes, et al. Pharmacokinetic actions of exendin-4 in the rat: Comparison with glucagon-like peptide-1. (2001), 53(4), 260–267.
[2] Affiliations, et al. GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans. Endocrinology. 2010 Jun;151(6):2629-40. DOI:10.1210/en.2009-0915

EXENDIN-4 (3-39)Supplier

Nanjing TGpeptide Biotechnology Co.,Ltd. Gold
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18115476705
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sales@tgpeptide.com
Shanghai HongTide Biotechnology Co.,Ltd. Gold
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15318089928
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alex@hanhonggroup.com
GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
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EXENDIN-4 (3-39)(196109-31-6)Related Product Information