ganoderenic acid A
ganoderenic acid A Basic information
- Product Name:
- ganoderenic acid A
- Synonyms:
-
- ganoderenic acid A
- (20E)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanosta-8,20(22)-dien-26-oic acid
- (20E)-7β,15α-Dihydroxy-3,11,23-trioxolanosta-8,20(22)-diene-26-oic acid
- Lanosta-8,20(22)-dien-26-oicacid, 7,15-dihydroxy-3,11,23-trioxo-, (7b,15a,20E)-
- Lanosta-8,20(22)-dien-26-oic acid, 7,15-dihydroxy-3,11,23-trioxo-, (7β,15α,20E)-
- 5R)-2-Isopropyl-5-Methylcyclohexanol
- (E)-6-((5R,7S,10S,13R,14R,15S,17R)-7,15-Dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
- Ganoderenic acid A, 10 mM in DMSO
- CAS:
- 100665-40-5
- MF:
- C30H42O7
- MW:
- 514.66
- Mol File:
- 100665-40-5.mol
ganoderenic acid A Chemical Properties
- Boiling point:
- 700.3±60.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 4.65±0.23(Predicted)
- color
- White to off-white
- InChIKey
- OVUOUFPIPZJGME-UHFFFAOYSA-N
- SMILES
- CC12C(CC(C(C)=CC(=O)CC(C)C(=O)O)C1(CC(=O)C1C3(CCC(=O)C(C)(C)C3CC(O)C2=1)C)C)O
ganoderenic acid A Usage And Synthesis
Description
Ganoderenic acid A is a triterpenoid originally isolated from G. lucidum that has enzyme inhibitory activities. It is an inhibitor of β-glucuronidase (IC50 = 0.12 mg/ml in rat liver microsomes). Ganoderenic acid A (100 mg/kg) reduces increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in a rat model of liver injury induced by carbon tetrachloride (CCl4). It also inhibits aldose reductase by 54.2% when used at a concentration of 100 μg/ml.
Uses
Carbidopa (monohydrate) (Standard) is the analytical standard of Carbidopa (monohydrate). This product is intended for research and analytical applications. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.
Definition
ChEBI: Ganoderenic acid A is a triterpenoid.
References
[1] Y. KOMODA. Structures of New Terpenoid Constituents of Ganoderma lucidum (Fr.) KARST (Polyporaceae)[J]. Chemical & pharmaceutical bulletin, 1985, 14 1: 4829-4835. DOI: 10.1248/cpb.33.4829
[2] D H KIM. Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.[J]. Biological & pharmaceutical bulletin, 1999, 22 2: 162-164. DOI: 10.1248/bpb.22.162
[3] SRI FATMAWATI Ryuichiro K Kuniyoshi Shimizu. Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum.[J]. Planta medica, 2010, 76 15: 1691-1693. DOI: 10.1055/s-0030-1249782
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ganoderenic acid A(100665-40-5)Related Product Information
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- Terrestrosin K
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- EPA
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- VIGABATRIN
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- cis-11-Eicosenoic acid
- Ganoderenic acid B
- Ganoderenic acid D
- (20E)-3β,7β,15α-Trihydroxy-11,23-dioxo-5α-lanosta-8,20(22)-dien-26-oic acid