Boc-L-Glutamic acid 1-benzyl ester Chemical Properties

Melting point:

95.0 to 99.0 °C

Boiling point:

522.6±50.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

refractive index 

-30 ° (C=0.7, MeOH)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

4.48±0.10(Predicted)

form 

Solid

color 

White

optical activity

-27.1°(C=0.01g/mI, MEOH, 20°C, 589nm)

BRN 

2482076

InChI

InChI=1S/C17H23NO6/c1-17(2,3)24-16(22)18-13(9-10-14(19)20)15(21)23-11-12-7-5-4-6-8-12/h4-8,13H,9-11H2,1-3H3,(H,18,22)(H,19,20)/t13-/m0/s1

InChIKey

CVZUKWBYQQYBTF-ZDUSSCGKSA-N

SMILES

C(OCC1=CC=CC=C1)(=O)[C@H](CCC(O)=O)NC(OC(C)(C)C)=O

CAS DataBase Reference

30924-93-7(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29242990

MSDS

• Language:English Provider:SigmaAldrich

Boc-L-Glutamic acid 1-benzyl ester Usage And Synthesis

Description

Boc-Glu-OBzl is an amino acid building block. It has been used in the synthesis of peptide-based inhibitors of human caspases and human rhinovirus (HRV) 3C protease that have enzyme inhibitory activity in vitro.

Chemical Properties

White Solid

Uses

N-Boc-L-glutamic Acid α-Benzyl Ester is an effective substrate for vitamin K-dependent carboxylase. N-Boc-L-glutamic Acid α-Benzyl Ester is a monopeptide used to study the interaction of nucleic acid bases with peptides.

Uses

Boc-L-Glutamic acid 1-benzyl ester is an effective substrate for vitamin K-dependent carboxylase,it is a monopeptide used to study the interaction of nucleic acid bases with peptides.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

References

[1] M GARCIA-CALVO. Inhibition of human caspases by peptide-based and macromolecular inhibitors.[J]. The Journal of Biological Chemistry, 1998, 273 49: 32608-32613. DOI: 10.1074/jbc.273.49.32608
[2] PETER S. DRAGOVICH. Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure?Activity Studies[J]. Journal of Medicinal Chemistry, 1998, 41 15: 2819-2834. DOI: 10.1021/jm9800696

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