(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide Chemical Properties

Melting point:

193-195 °C(lit.)

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Powder or Crystals

color 

White to light brown

Water Solubility 

Soluble in water (20°C).

Sensitive 

Hygroscopic

InChIKey

FRHRVQQUICVJDG-UHFFFAOYSA-M

CAS DataBase Reference

52509-14-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29329970

MSDS

• Language:English Provider:(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide Usage And Synthesis

Chemical Properties

white to light brown granular powder

Uses

(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens.

Uses

Reactant for:

• Preparation of a ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathione
• Microwave-assisted synthesis of KN-93 as inhibitor of calmodulin kinase II
• Preparation of fluorinated spirobenzofuran piperidines as s1 receptor ligands
• Synthesis and antitumor agents
• Regio-selective preparation of indole derivatives via rhodium-catalyzed domino hydroformylation/indolization

Purification Methods

Wash the crystals with Et2O, dry them in a vacuum and recrystallise them from CH2Cl2/dry Et2O to give prisms m 172-174o, which is raised to 191.5-193o on drying at 56o/0.5mm. [Cresp et al. J Chem Soc, Perkin Trans 1 37 1974.]

(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide(52509-14-5)Related Product Information

• Rocuronium bromide
• Diphenylphosphine
• 2-Bromomethyl-1,3-dioxolane
• Ethidium bromide
• Tetrakis(triphenylphosphine)palladium
• Sodium bromate
• Triphenylphosphine
• Methylmagnesium Bromide
• Methyl cyclopentenolone
• DBDCB
• Chlorodiphenylphosphine
• Triphenylphosphine hydrobromide
• METHYLCYCLOPENTADIENE DIMER
• Chlorodimethylphenylsilane
• Sodium bromide
• Allyl bromide
• Bromo-PEG1-t-butyl ester
• Diethyl bromodifluoromethanephosphonate