4-(Hydroxyamino)-4-oxobutanoic acid Chemical Properties

Melting point:

82-86 °C(Solv: acetonitrile (75-05-8))

Density 

1.436±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

5.28±0.10(Predicted)

4-(Hydroxyamino)-4-oxobutanoic acid Usage And Synthesis

Preparation

To a refluxing solution of 5.0 gm (0.05 mole) of succinic anhydride in 100 ml of benzene is added a solution of 6.3 gm (0.05 mole) of O-ben- zylhydroxylamine in 20 ml of benzene. As soon as the addition has been completed, the reaction mixture is cooled, and the precipitated product is separated. Upon recrystallization from a benzene-methyl ethyl ketone mixture, 7.6 gm (68.2%) of N-benzyloxysuccinamic acid, m.p. 95-96°C isolated.
A suspension of 4.3 gm (0.0193 mole) of this intermediate and a stron- tium carbonate catalyst containing 5% palladium in methyl ethyl ketone is hydrogenated. Upon working up the reaction mixture, 1.45 gm (56.7%) of succinomonohydroxamic acid, m.p. 95-96°C is isolated.

4-(Hydroxyamino)-4-oxobutanoic acid(4743-99-1)Related Product Information

• Tofacitinib Impurity 19
• Tofacitinib impurity T
• Methyl (4-Methylpiperidin-3-yl)carbaMate
• 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE
• BENZYL ETHYL ETHER
• 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine
• N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• Tofacitinib Impurity 85
• N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 4-Amino-2,6-dichloropyrimidine
• Malonyl chloride
• Benzyl chloride
• 6-AMINO-5(2,2-DIETHOXYETHYL)-4-HYDROXY-2-MERCAPTOPYRIMIDINE
• 1-Benzyl-4-methyl-piperidin-3-one hydrochloride
• CYANOACETIC ACID-OSU
• N-Hydroxysuccinimide
• Tofacitinib Impurity 29
• (3S,4S)-Tofacitinib