5-Fluoro-2-methoxyphenylboronic acid Chemical Properties

Melting point:

144-153 °C (lit.)

Boiling point:

337.1±52.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

soluble in Methanol

pka

7.52±0.58(Predicted)

form 

Crystalline Powder

color 

White

InChI

1S/C7H8BFO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4,10-11H,1H3

InChIKey

CCQKIRUMTHHPSX-UHFFFAOYSA-N

SMILES

COc1ccc(F)cc1B(O)O

CAS DataBase Reference

179897-94-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36/37/39-36-24/25

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29163990

Storage Class

13 - Non Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

5-Fluoro-2-methoxyphenylboronic acid Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

5-Fluoro-2-methoxyphenylboronic Acid is an important building blocks in organic syntheses. A reagent for Suzuki coupling reactions and copper catalyzed arylation reactions. A bacterial mutagen.

Uses

Reactant for:• ;Suzuki couplings1,2• ;Copper catalyzed arylation3

Uses

suzuki reaction

Synthesis

There are two main methods to synthesize 5-fluoro-2-methoxyphenylboronic acid: 1) Reacting with p-fluoroanisole and n-butyllithium solution dissolved in THF at -60 . ??, then react with triisopropyl borate at -70 ?? and then acidify with hydrochloric acid to obtain; 2) Use 2-bromo-4-fluoroanisole and n-butyllithium solution dissolved in THF first. 2) obtained by reacting 2-bromo-4-fluoroanisole with n-butyllithium solution dissolved in THF at -78 ??, then reacting with trimethyl borate at room temperature, then acidified with hydrochloric acid and washed with ammonium chloride solution.

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