2,3,4-Trimethoxybenzaldehyde Chemical Properties

Melting point:

38-40 °C(lit.)

Boiling point:

168-170 °C12 mm Hg(lit.)

Density 

1.2166 (rough estimate)

refractive index 

n20/D 1.5547(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

methanol: 0.1 g/mL, clear

form 

Crystals or Crystalline Powder

color 

White to light yellow

Sensitive 

Air Sensitive

BRN 

981091

InChI

InChI=1S/C10H12O4/c1-12-8-5-4-7(6-11)9(13-2)10(8)14-3/h4-6H,1-3H3

InChIKey

UCTUXUGXIFRVGX-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(OC)C(OC)=C1OC

CAS DataBase Reference

2103-57-3(CAS DataBase Reference)

NIST Chemistry Reference

Benzaldehyde, 2,3,4-trimethoxy-(2103-57-3)

EPA Substance Registry System

Benzaldehyde, 2,3,4-trimethoxy- (2103-57-3)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-34

Safety Statements 

22-24/25-45-36/37/39-27-26

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29124900

MSDS

• Language:English Provider:2,3,4-Trimethoxybenzaldehyde
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,3,4-Trimethoxybenzaldehyde Usage And Synthesis

Description

2,3,4-Trimethoxybenzaldehyde is a white crystalline powder, and the chemical formula is C 10H 12O 4; the molecular weight is 196.2; the fusing point is 38-40 degrees, and is a kind of important medicine intermediate; it is mainly used in new type drug Ca2+ Synthesizing of channel blocker. The alternative cerebral arteries that are used for this medicine reduce the headache incidence, mainly for the preparation of the intermediate of trimetazidine.

Synthesis

A coking gallic acid is utilized as a raw material, and dimethyl sulfate is utilized as an alkylate reagent; under the condition of the existence of sodium hydroxide, methylation is performed through an O-alkylation reaction to obtain an intermediate 1, 2, 3-trimethoxybenzene. After that, the 1,2, 3-trimethoxybenzene and a Vilsmeier-Haack reagent are subjected to a formylation reaction to get the 2,3,4-Trimethoxybenzaldehyde.

Chemical Properties

white to light yellow crystals or cryst. powder

Uses

2,3,4-Trimethoxybenzaldehyde is a trimethoxylated aromatic aldehyde. 2,3,4-Trimethoxybenzaldehyde is an Impurity of the anti-anginal drug Trimetazidine (T795610).

Uses

2,3,4-Trimethoxybenzaldehyde was used to study the effects of 2,3,4-trimethoxybenzaldehyde on tubulin-dependent GTP hydrolysis.

2,3,4-Trimethoxybenzaldehyde(2103-57-3)Related Product Information

• 3-(Trifluoromethyl)benzaldehyde
• 3-Methoxybenzaldehyde
• p-Anisaldehyde
• 4-(Trifluoromethoxy)aniline
• Trimethyl phosphite
• Mesitaldehyde
• 3-(Trifluoromethoxy)bromobenzene
• o-Anisaldehyde
• (Trifluoromethoxy)benzene
• 2,3,4-Trihydroxybenzaldehyde
• 2,3,4-TRIMETHOXYPHENYLACETIC ACID
• TriMethopriM IMpurity C
• 3-Iodobenzyl bromide
• 3-Anilino-2-(3,4,5-triMethoxybenzyl)acrylonitrile, (Mixture of cis/trans isoMers)
• Trimethoprim Related Compound B (25 mg) (2,4-diaminopyrimidin-5-yl)(3,4,5-trimethoxyphenyl)methanone) (AS)
• 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine
• 4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester
• 1-(3,4,5-TRIMETHOXY-BENZYL)-PIPERAZINE