Methyl gallate Chemical Properties

Melting point:

201-204 °C

Boiling point:

278.08°C (rough estimate)

Density 

1.3840 (rough estimate)

refractive index 

1.5690 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

ethanol: 50 mg/mL, clear

form 

Crystalline Powder

pka

8.04±0.23(Predicted)

color 

White to slightly beige

Water Solubility 

SOLUBLE IN HOT WATER

Merck 

14,4345

BRN 

2113180

InChIKey

FBSFWRHWHYMIOG-UHFFFAOYSA-N

LogP

0.860

CAS DataBase Reference

99-24-1(CAS DataBase Reference)

EPA Substance Registry System

Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-43

Safety Statements 

26-36/37-24/25

WGK Germany 

3

RTECS 

LW8000000

TSCA 

Yes

HS Code 

29182900

MSDS

• Language:English Provider:Methyl gallate
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl gallate Usage And Synthesis

Description

Methyl gallate is a phenolic compound found in Terminalia myriocarpa and Geranium niveum. It is also found in wine.
It is the methyl ester of gallic acid.

Description

Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities. It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 μM. Methyl gallate is active against V. cholerae in vitro (MIC = 32 μg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg. It reduces tumor growth and decreases the number of intratumor CD25⁺Foxp3^high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma. Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.

Chemical Properties

white to slightly beige crystalline powder

Uses

Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.

Uses

Methyl 3,4,5-trihydroxybenzoate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.

Uses

The gallate ester methyl gallate is used as an antioxidant. A ease was reported using a reprography paper.

Definition

ChEBI: Methyl 3,4,5-trihydroxybenzoate is a gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties. It has a role as a plant metabolite, an anti-inflammatory agent and an antioxidant.

Contact allergens

This ester of gallic acid is used as an antioxidant agent. A case was reported by using a reprography paper.

Purification Methods

Methyl gallate [99-24-1] M 184.2, m 202o. Crystallise the gallate ester from MeOH. [Beilstein 10 IV 1998.]

Methyl gallate(99-24-1)Related Product Information

• 2,3,4-Trihydroxybenzoic acid
• Paraquat dichloride
• Propyl gallate
• Methylparaben
• Methyl 3,4-dihydroxybenzoate
• Methyl acetate
• Methyl acrylate
• Basic Violet 1
• Ethyl gallate
• Methyl 3-hydroxybenzoate
• Salicylic acid
• Methanol
• Kresoxim-methyl
• Pyrogallol
• Gallic acid monohydrate
• 2'-Hydroxy-3-phenylpropiophenone
• Acetonitrile
• 3-Hydroxybenzoic acid