THP-PEG6-alcohol Chemical Properties

Boiling point:

469.0±45.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

14.36±0.10(Predicted)

color 

Colorless to light yellow

THP-PEG6-alcohol Usage And Synthesis

Description

THP-PEG7 is a PEG linker containing a THP protecting group and a hydroxyl group. THP is acid labile and is commonly used for the protection of alcohol groups. The terminal hydroxyl group can be further reacted to derivatize the compound. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Uses

THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC 50

PEGs; Non-cleavable Linker

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Masahiro Tomita, et al. Antibody specifically recognizing resin plasticizer compound. WO2005105846A1.

THP-PEG6-alcohol(42607-87-4)Related Product Information

• Pro-xylane
• Polyethylene Glycol Monocetyl Ether
• THP-PEG6
• TETRAHYDROPYRANYLDIETHYLENEGLYCOL
• THP-PEG5
• THP-PEG4
• THP-PEG7-OH